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Found 3765 clinical trials
Featured trial
An MRI-Study to Characterize Cerebrospinal Fluid Geometry and Dynamics in Individuals with Rett Syndrome

at the CNS target areas.Delivery of drugs to the CSF to help treat central nervous system diseases has shown promising pre-clinical and clinical results. However, at present, the

  • 15 Feb, 2022
  • 1 location
Featured trial
Advanced Non-Small Cell Lung Cancer

Advanced Non-Small Cell Lung Cancer

  • 08 Nov, 2020
  • 1 location
European Low and Intermediate Risk Neuroblastoma Protocol

The European study, LINES 2009 (Low and Intermediate Risk Neuroblastoma European Study), groups together in a single protocol the treatment of all patients with "non high risk" neuroblastoma (NB), with stratification into two groups: low risk and intermediate risk. These two separate cohorts are included in one single protocol to …

  • 23 Jan, 2021
  • 82 locations
Clinical Applications of (S)-[18F]FBFP PET/CT in Healthy Volunteers and Patients With Central Nervous System Diseases

diagnostic performance of (S)-[18F]FBFP in healthy volunteers and patients with central nervous system diseases. A single dose of nearly 370 MBq (S)-[18F]FBFP will be intravenously injected into healthy

Accepts healthy volunteers
  • 30 Apr, 2022
  • 1 location
A Phase IIIb, Multicenter, International Study to Evaluate the Efficacy, Safety and Tolerability of EK-12 in Patients With RRMS

Multiple sclerosis is a chronic autoimmune, inflammatory neurological disease of the central nervous system. It is the most common disabling neurologic disease of young people. This study is

magnetic resonance imaging brain
  • 03 Mar, 2022
  • 1 location
Clinical Study on the Effect of Improving Sleep Quality on Cognitive Function in Patients With Epilepsy

Epilepsy is one of the common chronic diseases of the central nervous system. 30% to 40% of patients with epilepsy have varying degrees of cognitive impairment, which affects their quality of

  • 15 Mar, 2022
Long-Term Analysis of DImethyl Fumarate, to Slow the Growth of Areas of Geographic Atrophy (LADIGAGA)

The primary objectives of the study are to assess the safety, tolerability and evidence of activity of 12 months oral treatment with TEFIDERA® in subjects with Geographic Atrophy associated with Age-Related Macular Degeneration (AMD).

retinal pigment
geographic atrophy
  • 24 Mar, 2022
Safety and Efficacy of Esmketamine Versus Dexmedetomidine

A comparative study on the safety and efficacy of esmketamine versus Dexmedetomidine during drug induced sleep endoscopy in children with positional obstructive sleep apnea: A consort-prospective, randomized, controlled clinical trial

  • 15 May, 2021
  • 1 location
Potential Role of Acupuncture Treatment in Neuronal and Network Dysfunction in Patients With Vascular Cognitive Impairment

Vascular cognitive impairment (VCI) is a broad dimensional term, ranging from mild cognitive impairment without incapacity on activity of daily living to vascular dementia (VaD), referred to as significant cognitive impairment and decline in function status. In this three-year project, we aim to evaluate the effects of biochemical data, early …

  • 23 Jan, 2021
  • 1 location
Use Of A Response-Adapted Ruxolitinib-Containing Regimen For The Treatment Of Hemophagocytic Lymphohistiocytosis

This study is a multi-site Phase Ib/II, 2-arm non-randomized clinical trial to determine the efficacy and tolerability of a response-adapted regimen combining ruxolitinib, dexamethasone, and etoposide as Frontline therapy for patients with newly diagnosed hemophagocytic lymphohistiocytosis (HLH) or as Salvage therapy for patients with relapsed/refractory HLH. Primary Objective To determine …

  • 17 May, 2022
  • 7 locations