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Found 113 clinical trials
Trial to Evaluate the Safety and Immunogenicity of a Modified Vaccinia Ankara (MVA)-Based Anti-Cytomegalovirus (CMV) Vaccine (Triplex®)

Participants will be randomized in a 2:1 ratio to receive either two injections of CMV-MVA Triplex® or placebo administered at study Entry/Day 0 and week 4. Vaccine Group: 60 participants

western blot
ritonavir
HIV Vaccine
antibody response
reverse transcriptase inhibitor
  • 3 views
  • 11 Jul, 2022
  • 10 locations
A Multi-Site, Randomized Trial of Subject-Collected Dried Blood Spot CMV Testing With Mobile Technology Support to Optimize Preemptive Therapy Late After Allogeneic HCT

Cytomegalovirus (CMV) testing of Hematopoietic cell transplantation (HCT) recipients who are at high risk for late CMV disease. In this study, mobile devices will be used to remind HCT survivors to perform CMV

valganciclovir
letermovir
hla-a
stem cell transplantation
foscarnet
  • 43 views
  • 24 Oct, 2022
  • 4 locations
Clinical Trial of Efficacy and Safety of the Combination of Reduced Duration Prophylaxis Followed by Immuno-guided Prophylaxis in Lung Transplant Recipients. (CYTOCOR)

To assess the efficacy of reduced duration prophylaxis followed by immuno-guided prophylaxis to prevent cytomegalovirus disease.

dhpg
ganciclovir
valganciclovir
  • 1 views
  • 17 Feb, 2022
  • 6 locations
A Phase 3, Open-Label, Single-Arm Study to Assess the Efficacy, Safety, and Pharmacokinetics of Maribavir for the Treatment of Cytomegalovirus (CMV) Infection in Japanese Recipients of a Hematopoietic Stem Cell Transplant (HSCT) or Solid Organ Transplant (SOT)

The main aim of the study is to check if treatment with maribavir can protect Japanese people against Cytomegalovirus (CMV) infection, and to check side effect from the study treatment and how

  • 0 views
  • 22 Oct, 2022
  • 20 locations
A Study of Safety and Immune Response to Different Doses of a Cytomegalovirus Vaccine in Healthy Adults

The purpose of this study is to assess the safety, reactogenicity and immunogenicity of the candidate CMV recombinant protein subunit (CMVsu) vaccine consisting of a combination of glycoproteins

Accepts healthy volunteers
  • 43 views
  • 07 Oct, 2022
  • 14 locations
Multicenter Clinical Trial to Evaluate the Efficacy of a Preventive Strategy Against CMV Infection in Heart Transplant Patients Based on the Specific T Cells Response

This study evaluates the efficacy and safety of an individualized preventive strategy against CMV infection in CMV seropositive heart transplant patients based on the specific basal response of

ifn-g
  • 12 views
  • 28 Jan, 2021
  • 1 location
A Dose-Escalation Study Evaluating Safety and Tolerability of Viral-Specific T Cells Against CMV in Adult Solid Organ Transplant Recipients

This study measures the tolerability of viral-specific T cells against Cytomegalovirus (CMV) in adult solid organ transplant (SOT) recipients. Participants are expected to be on study for 52

dhpg
viremia
letermovir
hla-a
valganciclovir
  • 2 views
  • 15 Feb, 2022
  • 1 location
Viral Specific T-Lymphocytes to Treat Adenovirus, CMV and EBV

The primary purpose of this phase I/II study is to evaluate whether partially matched, ≥2/6 HLA-matched, viral specific T cells have efficacy against adenovirus, CMV, and EBV, in subjects who

antiviral therapy
pneumonia
organ transplantation
cidofovir
foscarnet
  • 6 views
  • 04 Oct, 2022
  • 1 location
Study to Evaluate the Safety, Reactogenicity and Immunogenicity of Modified mRNA Vaccines Using a Systems Biology Approach in Healthy Adults

The main goal of this study is to evaluate the safety, reactogenicity, and immunogenicity of study vaccines.

Accepts healthy volunteers
  • 8 views
  • 16 Oct, 2022
  • 6 locations
Randomized, Controlled Trial to Evaluate the Anti-inflammatory Efficacy of Letermovir (Prevymis) in Adults With Human Immunodeficiency Virus (HIV)-1 and Asymptomatic Cytomegalovirus (CMV) Who Are on Suppressive ART and Its Effect on Chronic Inflammation, HIV Persistence, and Other Clinical Outcomes (ELICIT)

This is an open-label, controlled study, conducted at US sites to evaluate the anti-inflammatory effectiveness of the study drug letermovir in adults with HIV and asymptomatic cytomegalovirus

immunodeficiency
hiv-1 rna measurement
immune globulin
antiretroviral therapy
atazanavir
  • 0 views
  • 10 Oct, 2022
  • 2 locations