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Found 4 clinical trials
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Study of Efficacy and Safety of MBG453 in Combination With Azacitidine in Subjects With Intermediate High or Very High Risk Myelodysplastic Syndrome (MDS) as Per IPSS-R or Chronic Myelomonocytic Leukemia-2 (CMML-2)

or very high risk myelodysplastic syndrome (MDS) as per IPSS-R, or Chronic Myelomonocytic Leukemia-2 (CMML-2) who have an indication for treatment with azacitidine in first-line setting and are not

chronic myelomonocytic leukemia
myelomonocytic leukemia
leukemia
high risk myelodysplastic syndrome
azacitidine
  • 7 views
  • 25 Nov, 2021
  • 138 locations
None
Tagraxofusp (SL-401) in Patients With CMML or MF

(MF). There are two CMML cohorts, one enrolling patients with CMML (CMML-1 or CMML-2) who are refractory/resistant or intolerant to hypomethylating agents (HMA), hydroxyurea (HU), or intensive

chronic myelomonocytic leukemia
neutrophil count
anemia
dysplasia
monocytosis
  • 145 views
  • 16 Aug, 2021
  • 13 locations
None
Combining Active and Passive DNA Hypomethylation

patients with higher-risk MDS, CMML-2 or low-blast count AML. The primary purpose is to investigate if oral vitamin C supplementation to azacitidine, compared with azacitidine + placebo, can increase the

chronic myelomonocytic leukemia
myeloproliferative disorder
blast cells
azacitidine
cancer
  • 0 views
  • 08 Oct, 2021
  • 6 locations
None
Seclidemstat and Azacitidine for the Treatment of Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia

This phase I/II trial identifies the best dose of seclidemstat when given together with azacitidine in treating patients with myelodysplastic syndrome or chronic myelomonocytic leukemia. Seclidemstat may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Azacitidine may help block the formation of …

chronic myelomonocytic leukemia
myelomonocytic leukemia
leukemia
granulocyte colony stimulating factor
azacitidine
  • 0 views
  • 07 Sep, 2021
  • 1 location