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Found 13 clinical trials
Safety and Efficacy of Low Temperature Rota-flush Solution in Patients With Severe Calcified Lesion (LOTA-II)

Calcified lesions related to coronary artery are a type of atherosclerosis, accompanied by severe calcified lesions of the stenosis, which is a difficult point for PCI interventional therapy. Calcified lesions have poor response to balloon dilatation and the device can not be successfully placed, which reduce the success rate of …

single coronary artery
  • 25 Jan, 2021
  • 9 locations
Effects of Blocking Blue Light at Night on Patient Outcomes After Elective CABG Surgery

Cardiovascular disease is the leading cause of death in the US. Each year, more than 500,000 coronary revascularization surgeries are performed. The in-hospital mortality rate among patients undergoing coronary artery bypass graft (CABG) surgery has declined to less than 6% in recent years, but potentially serious complications still occur and …

  • 18 Apr, 2021
  • 1 location
Dexamethasone for Cardiac Surgery-II Trial

Background. Numerous studies have investigated high-dose corticosteroids in cardiac surgery, but with mixed results leading to ongoing variations in practice around the world. The Dexamethasone for Cardiac Surgery-II Trial (DECS-II) is a study comparing high-dose dexamethasone with placebo in patients undergoing cardiac surgery. Methods. We discuss the rationale for conducting …

  • 26 Jan, 2021
  • 1 location
A Prospective Randomized Study Comparing Radiofrequency Energy With Cryoenergy

damage and inflammatory response (t-troponin, CK, CK-MB, vWF, PAI-1, micro particles, platelet activation/overall function, CRP, IL-6, IL-8, IL-10, TNF alpha, procalcitonin) will be

  • 07 Nov, 2020
  • 1 location
A Study of Hemopure to Enhance Tissue Preservation During Cardiopulmonary Bypass Surgery

The purpose of this study is to determine if Hemopure® will enhance tissue preservation during Cardiopulmonary Bypass surgery.

bypass surgery
bypass graft
  • 07 Nov, 2020
  • 1 location
Safety and Efficacy of Low Temperature Contrast in UAP Patients During PCI

Percutaneous coronary intervention (PCI) has become one of the main treatments for rapid recovery of revascularization in patients with coronary heart disease (CHD). PCI has some advantages, such as easy operation, small trauma and rapid recovery. It can significantly improve myocardial ischemic symptom and reduce the incidence of cardiovascular adverse …

unstable angina
angina pectoris
percutaneous coronary intervention
heart disease
  • 25 Jan, 2021
  • 9 locations
PIoglitazone for PrEvention of Restenosis in Diabetic Patients

Restenosis requiring reintervention is still a limitation of percutaneous coronary angioplasty. Despite the use of Drug eluting stent (DES), the rate of restenosis remains 7% to 16% in diabetic patients, making it a challenging problem in interventional cardiology. Still, in clinical trials, most of these attempts did not successfully limit …

intimal proliferation
type 2 diabetes mellitus
  • 07 Nov, 2020
  • 1 location
Helping Stroke Patients With ThermoSuit Cooling

The aim of this study is to assess the feasibility of using the Life Recovery Systems ThermoSuit Device to induce therapeutic hypothermia (32-34C) in victims of ischemic stroke. This feasibility clinical study will enroll a total of 30 patients with acute ischemic stroke at four clinical centers. Subjects will receive …

ischemic stroke
  • 28 Feb, 2021
  • 4 locations
Evaluation of Cardiotoxicity and Hypertension in Patients With Non Metastatic Castration Resistant Prostatic Carcinoma

This is a prospective observational study on a cohort of patients with castration-resistant prostate cancer M0, treated with Apalutamide, at the Oncology Unit of the "Andrea Tortora" Hospital of Pagani. Data will be collected on the patient's clinical history and the treatments carried out until the start of therapy with …

  • 26 Jan, 2021
  • 2 locations
Prospective Cohort Study on Minimal Invasive Coronary Surgery

CABG technology is recognized as the preferred treatment, and its major adverse cardiac and cerebral event(MACCE) incidence and mortality are lower than percutaneous coronary intervention(PCI). However, the traditional CABG procedure requires sternal incision, large trauma and long recovery period after surgery. How to reduce trauma and treat multiple complex coronary …

  • 26 Jan, 2021
  • 1 location