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Found 17 clinical trials
Efficacy and Safety of Benralizumab in EGPA Compared to Mepolizumab.

This is a randomized, double blind, active-controlled, parallel group, multicenter 52-week Phase 3 study to compare the efficacy and safety of benralizumab 30 mg versus mepolizumab 300 mg administered by subcutaneous (SC) injection in patients with relapsing or refractory EGPA on corticosteroid therapy with or without stable immunosuppressive therapy. All …

steroid therapy
purpura
immunosuppressive agents
eosinophilia
nasal abnormality
  • 20 views
  • 05 May, 2021
  • 77 locations
Analgesic Effect of rTMS in Vasculitic Neuropathy

Vasculitic neuropathy (VN) results from inflammation and destruction of the walls of predominantly small vessels with subsequent ischemic damage of peripheral nerves. VN is painful in vast majority of patients and the pain is intractable with pharmacotherapy in about 40% of cases. Repetitive Transcranial Magnetic Stimulation (rTMS) is a noninvasive …

  • 0 views
  • 28 Jan, 2021
  • 1 location
Maintenance of Remission With Rituximab Versus Azathioprine for Newly-diagnosed or Relapsing Eosinophilic Granulomatosis With Polyangiitis.

relapsing or newly-diagnosed Eosinophilic granulomatosis with polyangiitis EPGA receiving standard of care therapy including glucocorticoid therapy reduction/withdrawal.

azathioprine
maintenance therapy
immunosuppressive agents
vasculitis
rituximab
  • 0 views
  • 22 Jan, 2021
  • 1 location
PRagmatic Analysis of Vitamin D in ANCA-Associated Vasculitis

This prospective study will assess if 12 months of vitamin D3 (cholecalciferol) supplementation, in patients with AAV (GPA, MPA, and EGPA) who have deficient or insufficient 25(OH)D3 status at enrollment, correlates with improved disease activity and/or lower frequency of relapse (compared to historical data and a previously conducted cross sectional …

anca
anti-neutrophil cytoplasmic antibody
vasculitis
anca-associated vasculitides
vitamin d
  • 32 views
  • 26 Jan, 2021
  • 1 location
Low Dose Naltrexone to Improve Physical Health in Patients With Vasculitis

Naltrexone is an FDA approved drug (for alcoholism) that has found widespread use "off-label" to treat pain and improve quality of life at much lower doses than are used for the approved indication. There are a few scientific studies in three conditions (fibromyalgia, Crohn's disease, and multiple sclerosis) that suggest …

immunosuppressive agents
polyarteritis
angiography
enzyme immunoassay
glomerulonephritis
  • 15 views
  • 28 Mar, 2021
  • 5 locations
Hydroxychloroquine in ANCA Vasculitis Evaluation

rheumatoid arthritis. The study is open to adults diagnosed with certain types of vasculitis, called Granulomatosis Polyangiitis (GPA), Microscopic Polyangiitis (MPA) or Eosinophilic Granulomatosis

  • 0 views
  • 26 Jan, 2021
  • 3 locations
Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung Disease

This is a single centre exploratory study that aims to apply hyperpolarized xenon-129 (129Xe) magnetic resonance imaging (MRI) methods and measurements in individual patients with and without lung disease to better understand lung structure and function and evaluate response to therapy delivered as a part of clinical care.

bronchopulmonary dysplasia
malnourished
trypsin
pulmonary fibrosis
dysplasia
  • 476 views
  • 26 Jan, 2021
  • 1 location
Mepolizumab Long-term Study to Assess Real World Safety and Effectiveness of Eosinophilic Granulomatosis With Polyangiitis (EGPA) in Japan

Eosinophilic granulomatosis with polyangiitis (EGPA), formerly known as the Churg-Strauss syndrome, is a systemic necrotizing vasculitis that affects small and medium sized blood vessels. NUCALA

  • 0 views
  • 11 Apr, 2021
  • 9 locations
Pediatric Vasculitis Initiative

Childhood chronic vasculitis describes a group of rare life-threatening diseases that have in common inflammation of blood vessels in vital organs such as kidneys, lungs and brain. Most knowledge about them comes from adult patients. Severe disease requires aggressive life-saving treatments with steroids and some cancer drugs which can themselves …

nervous
arteritis
vasculitis
polyarteritis
churg-strauss syndrome
  • 261 views
  • 26 Jan, 2021
  • 40 locations
VCRC Tissue Repository

The purpose of this study is to collect existing tissue specimens from subjects enrolled in Vasculitis Clinical Research Consortium (VCRC) studies. Analysis of these tissue specimens and linked clinical data collected through VCRC studies may lead to the identification and development of a series of translational research projects. Results of …

diagnostic tests
vasculitis
vascular diseases
vascular disease
  • 94 views
  • 02 Apr, 2021
  • 8 locations