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Found 314 clinical trials
A Phase 3 Open-Label, Randomized Study of Pirtobrutinib (LOXO-305) Versus Bendamustine Plus Rituximab in Untreated Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (BRUIN CLL-313)

The purpose of this study is to compare the efficacy and safety of pirtobrutinib (LOXO-305; Arm A) compared to BR (Arm B) in patients with CLL/SLL who have not been treated. Participation could

bendamustine
chronic lymphocytic leukemia
neutrophil count
lymphoma
rituximab
  • 1 views
  • 27 Oct, 2022
  • 118 locations
Ibrutinib Monotherapy Versus Fixed-duration Venetoclax Plus Obinutuzumab Versus Fixed-duration Ibrutinib Plus Venetoclax in Patients With Previously Untreated Chronic Lymphocytic Leukaemia (CLL) (CLL17)

progression-free survival (PFS) in patients with previously untreated CLL.

obinutuzumab
ibrutinib
cytopenia
neutrophil count
thrombocytopenia
  • 3 views
  • 24 Mar, 2022
  • 105 locations
Safety and Preliminary Efficacy of JBH492 Monotherapy in Patients With CLL and NHL

The purpose of the First-In-Human study is to assess safety, tolerability, pharmacokinetics (PK), immunogenicity and preliminary efficacy of JBH492 as single agent.

leukemia
chronic lymphocytic leukemia
lymphoma
hodgkin's disease
lymphoid leukemia
  • 13 views
  • 16 Jun, 2022
  • 8 locations
A Phase IB Open-Label, Multicenter Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia

This study will assess the safety, tolerability, pharmaokinetics, and preliminary efficacy of mosunetuzumab in participants with relapsed or refractory (R/R) chronic lymphocytic leukemia

cytopenia
chronic lymphocytic leukemia
  • 0 views
  • 16 Oct, 2022
  • 15 locations
A Multicenter, Open-Label, Phase 2 Study to Evaluate the Efficacy and Safety of Venetoclax-Obinutuzumab Retreatment in Patients With Recurring Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia (CLL) is the most common leukemia (cancer of blood cells). The purpose of this study is to assess how well venetoclax + obinutuzumab (VenG) works and how safe they

obinutuzumab
chronic lymphocytic leukemia
cancer
remission
venetoclax
  • 0 views
  • 28 Oct, 2022
  • 14 locations
A Study of Oral LOXO-305 in Patients With Previously Treated CLL/SLL or NHL

This is an open-label, multi-center Phase 1/2 study of oral LOXO-305 (pirtobrutinib) in patients with CLL/SLL and NHL who have failed or are intolerant to standard of care.

renal function
r-chop
diffuse large b-cell lymphoma
chronic lymphocytic leukemia refractory
btk inhibitor
  • 188 views
  • 04 Oct, 2022
  • 59 locations
A Phase 1, Open-Label Study of the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-64264681 in Participants With Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia

The purpose of the study is to determine the recommended Phase 2 dose(s) (RP2D[s]) in B cell non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL) in Part 1 and to evaluate the

leukemia
chronic lymphocytic leukemia
beta human chorionic gonadotrophin
lymphoma
hodgkin's disease
  • 29 views
  • 23 Oct, 2022
  • 14 locations
  • 25 views
  • 28 Oct, 2022
  • 17 locations
Study of Iopofosine I 131 (CLR 131) in Select B-Cell Malignancies (CLOVER-1) and Pivotal Expansion in Waldenstrom Macroglobulinemia (CLOVER-WaM)

Part A of this study evaluates iopofosine I 131 (CLR 131) in patients with select B-cell malignancies (multiple myeloma( MM), indolent chronic lymphocytic leukemia (CLL)/small lymphocytic

large b-cell lymphoma
progressive disease
carfilzomib
cancer chemotherapy
b-cell lymphoma
  • 735 views
  • 04 Oct, 2022
  • 18 locations
  • 389 views
  • 13 Oct, 2022
  • 20 locations