Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 85 clinical trials
Atorvastatin to Reduce Inflammation After Tuberculosis Treatment Completion

This is a proof-of-concept phase IIB, double-blind, randomized, placebo-controlled trial to evaluate the safety and efficacy of 40 mg atorvastatin to reduce persistent lung inflammation after successful TB treatment completion in HIV-infected and HIV-uninfected adults measured by PET/CT.

  • 0 views
  • 27 Jan, 2021
  • 1 location
Inspiratory Muscle Training in Difficult to Wean Patients

Prolonged mechanical ventilation secondary to weaning failure demands a significant amount of intensive care unit (ICU) resources, thus increasing the economic burden of public healthcare costs. One of the proposed mechanisms accounting for weaning failure is the concept that excessive work of breathing for weak respiratory muscles during the liberation …

weakness
mechanical ventilation
inspiratory muscle training
  • 4 views
  • 12 Feb, 2022
  • 1 location
Positive End-Expiratory Pressure (PEEP) Levels During Resuscitation of Preterm Infants at Birth (The POLAR Trial).

lungs are hardest to open and then decrease the PEEP later once the lungs are opened and the baby is breathing. Very premature babies have a risk of long-term lung disease (chronic lung disease

positive end expiratory pressure
mechanical ventilation
chronic lung disease
assisted ventilation
  • 0 views
  • 14 Nov, 2021
  • 19 locations
Efficacy + Safety of Liposome Cyclosporine A to Treat Bronchiolitis Obliterans Post Single Lung Transplant (BOSTON-1) (BOSTON-1)

The objective of the trial is to assess efficacy and safety of add-on aerosolized liposomal cyclosporine A (L-CsA) to Standard of Care (SoC) therapy as compared to SoC therapy alone in the treatment of Bronchiolitis obliterans syndrome (BOS) in single lung transplant recipients.

lung transplant
immunosuppressive agents
pulmonary disease
therapeutic agents
azathioprine
  • 3 views
  • 24 Apr, 2022
  • 26 locations
Efficacy + Safety of Liposome Cyclosporine A to Treat Bronchiolitis Obliterans Post Single Lung Transplant (BOSTON-2) (BOSTON-2)

The objective of the trial is to assess efficacy and safety of add-on aerosolized liposomal cyclosporine A (L-CsA) to Standard of Care (SoC) therapy as compared to SoC therapy alone in the treatment of Bronchiolitis obliterans syndrome (BOS) in double lung transplant recipients.

lung transplant
immunosuppressive agents
pulmonary disease
therapeutic agents
azathioprine
  • 18 views
  • 24 Apr, 2022
  • 40 locations
Progesterone to Prevent Preterm Delivery

-term neurological disabilities, and it is the second most common cause of death in children under the age of 5 year. Neonates born preterm are at risk of respiratory distress syndrome, chronic lung

  • 0 views
  • 23 Jan, 2021
  • 1 location
ISCHEMIA-CTO Trial - Revascularisation or Optimal Medical Therapy of CTO (ISCHEMIA-CTO)

following heart team conference Life expectancy < 2 years Severe chronic pulmonary disease (FEV1 < 30 % of predicted value) Contraindication to dual anti-platelet therapy

bypass graft
heart failure
myocardial infarction
coronary artery disease
percutaneous coronary intervention
  • 56 views
  • 22 Mar, 2022
  • 15 locations
Validation of Patient Reported Outcome Measures in Participants With Nontuberculous Mycobacterial Lung Infection Caused by Mycobacterium Avium Complex (ARISE)

The primary objective of this study is to generate evidence demonstrating the domain specification (via modern psychometric methods), reliability, validity, and responsiveness (within-subject meaningful change) of the Patient-Reported Outcome (PRO) endpoints.

  • 0 views
  • 12 May, 2022
  • 128 locations
Finding the Optimal Regimen for Mycobacterium Abscessus Treatment

Mycobacterium abscessus (MABS) is a group of rapid-growing, multi-drug resistant non-tuberculous mycobacteria (NTM) causing infections in humans. MABS pulmonary disease (MABS-PD) can result in significant morbidity, increased healthcare utilisation, accelerated lung function decline, impaired quality of life, more challenging lung transplantation, and increased mortality. While the overall numbers affected is …

  • 123 views
  • 25 Jan, 2021
  • 36 locations
Tuberculosis (TB) Aftermath

TB Aftermath will compare effectiveness, cost-effectiveness and feasibility of two ACF strategies that are presently being considered by the RNTCP for detecting recurrent TB and provide evidence needed to implement and scale the preferred intervention. The proposed study will address this gap, through the following specific aims: Primary Aim 1: …

Accepts healthy volunteers
  • 0 views
  • 12 May, 2022
  • 1 location