Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 73 clinical trials
Azacitidine and Homoharringtonine in JMML

Juvenile myelomonocytic leukemia (JMML) has a poor prognosis in general, with hematopoietic stem cell transplant (HSCT) remaining the standard of care for cure. Azacitidine and homoharringtonine

myeloid leukemia
refractory acute myeloid leukemia (aml)
azacitidine
  • 0 views
  • 24 Jan, 2021
  • 1 location
Study of ASTX727 vs IV Decitabine in MDS CMML and AML

Multicenter, randomized, open-label, crossover PK study of ASTX727 versus IV decitabine. Adult subjects who are candidates to receive IV decitabine will be randomized 1:1 to receive the ASTX727 tablet Daily5 in Cycle 1 followed by IV decitabine 20 mg/m^2 Daily5 in Cycle 2, or the converse order. After completion of …

secondary aml
chronic myelomonocytic leukemia
induction chemotherapy
secondary myelodysplastic syndrome
conjugated bilirubin
  • 269 views
  • 17 Jan, 2021
  • 93 locations
Study of Efficacy and Safety of MBG453 in Combination With Azacitidine in Subjects With Intermediate High or Very High Risk Myelodysplastic Syndrome (MDS) as Per IPSS-R or Chronic Myelomonocytic Leukemia-2 (CMML-2)

or very high risk myelodysplastic syndrome (MDS) as per IPSS-R, or Chronic Myelomonocytic Leukemia-2 (CMML-2) who have an indication for treatment with azacitidine in first-line setting and are not

chronic myelomonocytic leukemia
leukemia
myelomonocytic leukemia
cmml-2
high risk myelodysplastic syndrome
  • 5 views
  • 17 Jan, 2021
  • 72 locations
A Study Evaluating Safety and Tolerability and Pharmacokinetics of Navitoclax Monotherapy and in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasm

navitoclax is evaluated on the PK, safety, and tolerability of a single dose of celecoxib in participants with myeloproliferative neoplasm (MPN) or chronic myelomonocytic leukemia (CMML).

bone marrow procedure
chronic myelomonocytic leukemia
polycythemia vera
thrombocytosis
ruxolitinib
  • 1 views
  • 23 Dec, 2020
  • 23 locations
Ruxolitinib for the Treatment of Chronic Myelomonocytic Leukemia (CMML): A Phase 2 Expansion

This study is to find out if treating Chronic Myelomonocytic Leukemia (CMML) with a study drug (ruxolitinib) can improve outcomes of patients with CMML.

myeloproliferative disorder
chronic myelomonocytic leukemia
  • 3 views
  • 05 Nov, 2020
  • 3 locations
IO-202 as Monotherapy in Patients in AML and CMML

To assess safety and tolerability at increasing dose levels of IO-202 in successive cohorts of participants with relapsed or refractory monocytic AML and CMML in order to estimate the maximum

tacrolimus
neoadjuvant therapy
induction chemotherapy
cyclosporine
chronic myelomonocytic leukemia
  • 0 views
  • 24 Sep, 2020
  • 1 location
Tagraxofusp (SL-401) in Patients With CMML or MF

This multi-center, multi-arm trial is evaluating the safety and efficacy of tagraxofusp, a CD123-targeted therapy, in patients with either chronic myelomonocytic leukemia (CMML) or myelofibrosis

neutrophil count
monocytosis
chronic myelomonocytic leukemia
thrombocytosis
myelomonocytic leukemia
  • 145 views
  • 24 Jan, 2021
  • 13 locations
Dose-escalation Study of Oral Administration of LP-108 in Patients With Relapsed or Refractory Myelodysplastic Syndromes (MDS) Chronic Myelomonocytic Leukemia (CMML) or Acute Myeloid Leukemia (AML)

Refractory Myelodysplastic Syndromes (MDS), Chronic Myelomonocytic Leukemia (CMML), or Acute Myeloid Leukemia (AML)

raeb
chronic myelomonocytic leukemia
hematologic malignancy
leukemia
myelomonocytic leukemia
  • 0 views
  • 24 Jan, 2021
  • 1 location
AZD6738 for Patients With Progressive MDS or CMML

This research study is studying a research drug called AZD6738 as a possible treatment for Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia .

  • 0 views
  • 17 Jan, 2021
  • 3 locations
Study of NMS-03592088 in Patients With Relapsed or Refractory AML or CMML

Myeloid Leukemia (AML) or Chronic Myelomonocytic Leukemia (CMML).

chronic myelomonocytic leukemia
refractory acute myeloid leukemia (aml)
hydroxyurea
flt3 internal tandem duplication
induction chemotherapy
  • 6 views
  • 24 Jan, 2021
  • 4 locations