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Found 99 clinical trials
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Short-term Survival of Subjects With Acute-on-chronic Liver Failure After Plasma Exchange With Human Serum Albumin 5%

liver failure (ACLF) subjects. The study will involve approximately 40 study centers in the United States, Canada, and Europe with expertise in the management of subjects with ACLF. Subjects

plasma exchange
  • 35 views
  • 30 Sep, 2021
  • 45 locations
None
Effects of Long-Term Administration of Human Albumin in Subjects With Decompensated Cirrhosis and Ascites

with ascites (or with prior history of ascites requiring diuretic therapy) with or without acute-on-chronic liver failure (ACLF) at admission or during hospitalization but without ACLF at discharge.

  • 22 views
  • 25 Jul, 2021
  • 66 locations
None
Platelet Transfusion in Acute-on Chronic Liver Failure

Acute on-chronic liver failure (ACLF) is a severe liver disease with a 28-day mortality rate of up to 40%. When the patients get 3 or more organ failures, the 28-day mortality rate is up to 82.6

  • 0 views
  • 26 Jan, 2021
  • 8 locations
None
Study to Evaluate the Efficacy and Safety of HepaStem in Patients With Acute on Chronic Liver Failure (ACLF)

This is an interventional, double blind, randomized (2:1), and placebo-controlled study of 1 dose regimen of HepaStem in patients recently diagnosed (1 week) with ACLF grade 1 or 2 on top of Standard of Care (SoC), and for whom the diagnosis is not resolved on the day of infusion.

dose regimen
  • 0 views
  • 09 Jan, 2022
  • 8 locations
None
A Comparison of Invasive and Non-invasive Measurement of CI and SVR in Liver Transplantation

Patients who are scheduled to receive living donor liver transplantation will be monitored with a radial and femoral arterial line. A pulmonary artery catheter will also be placed and central venous pressure, cardiac index, and cardiac output will also be monitored. Simultaneously, on the middle finger of the hand where …

  • 0 views
  • 03 Jul, 2021
  • 1 location
None
Mesenchymal Stem Cells Treatment for Decompensated Liver Cirrhosis

Decompensated liver cirrhosis is a life-threatening chronic liver disease with high mortality. Liver transplantation is the only option that can improve the survival of these patients; however, this procedure is associated with several limitations, such as the severe shortage of donor livers, long waiting lists, multiple complications, and high cost. …

  • 37 views
  • 23 Jan, 2021
  • 1 location
None
Treatment With Human Umbilical Cord-derived Mesenchymal Stem Cells for Decompensated Cirrhosis

Decompensated cirrhosis has a high overall mortality rate. There is a large unmet need for safe and alternative therapeutic potions. This clinical trial is to inspect the efficiency and safety of mesenchymal stem cells (MSCs) therapy for decompensated cirrhosis.

  • 0 views
  • 21 Nov, 2021
  • 5 locations
None
CNI-free "Bottom"-up Immunosuppression in Patients Undergoing Liver Transplantation

The primary objective of the trial is to evaluate efficacy and safety of delayed introduction (up to 30 days post-transplantation in patients without signs of acute rejection that had received an aIL-2 induction and MMF) of either cyclosporine or everolimus versus a 5-day delay of cyclosporine in combination with MMF.

immunosuppression
liver transplant
cyclosporine
everolimus
  • 12 views
  • 08 Nov, 2020
  • 1 location
None
Introducing Palliative Care (PC) Within the Treatment of End Stage Liver Disease (ESLD)

This is a comparative effectiveness study of two pragmatic models aiming to introduce palliative care for end stage liver disease patients. The 2 comparators are: Model 1: Consultative

cancer
liver disease
functional assessment
  • 8 views
  • 01 Feb, 2021
  • 19 locations
None
Custodiol-N Solution Compared With Custodiol Solution in Organ Transplantation (Kidney Liver and Pancreas)

Synopsis Title of Study A prospective, randomized, single blind multicentre phase III study on organ preservation with Custodiol-N compared with Custodiol solution in organ transplantation (kidney, liver and pancreas) Protocol number: CL-N-KLP-TX-III/07-AT/17 Trial design The study design is a prospective, randomized, single blind, multicentre, phase III comparison study of organ …

kidney transplant
organ transplantation
  • 9 views
  • 23 Jan, 2021
  • 1 location