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Found 22 clinical trials
Lentiviral Gene Therapy for CGD

This is a Phase I/II clinical trial of gene therapy for treating Chronic Granulomatous Disease using a high-safety, high-efficiency, self-inactivating lentiviral vector TYF to functionally

gene therapy
  • 38 views
  • 23 Jan, 2021
  • 1 location
Haploidentical Transplant for People With Chronic Granulomatous Disease (CGD) Using Alemtuzumab Busulfan and TBI With Post-Transplant Cyclophosphamide

Background CGD causes infections and inflammation. The only cure currently is a bone marrow transplant. Most often a perfectly matched bone marrow donor is used

bone marrow transplant
sirolimus
alemtuzumab
blood test
stem cell transplantation
  • 1 views
  • 27 Apr, 2021
  • 1 location
Gene Therapy for X-CGD

X-linked chronic granulomatous disease (X-CGD) is a rare inherited immune defect, which is caused by the inability of phagocytic cells to produce reactive oxygen species due to a defect in the

  • 1 views
  • 08 Nov, 2020
  • 1 location
Plerixafor/G-CSF as Additional Agents for Conditioning Before HSCT in CGD Patients

granulomatous disease

gcsf
g-csf
stem cell transplantation
  • 0 views
  • 23 Jan, 2021
  • 1 location
Human Milk for Congenital Gastrointestinal Disorders

This study aims to identify whether an exclusive human milk diet (EHMD) would improve outcomes in neonates with congenital gastrointestinal disorders (CGD) and by facilitating an earlier

  • 3 views
  • 26 Jan, 2021
  • 1 location
Improving White Blood Cell Collection From Healthy Donors

Background White blood cells called granulocytes help the body fight infection. People who have had chemotherapy or bone marrow transplants may have very low numbers of these cells. Transfusions of these cells can help improve the body's ability to fight infection. However, most of the cells are located in the …

  • 35 views
  • 26 Jan, 2021
  • 1 location
Vitamin D3 For CGD Patients With BCGosis/Itis

When children with chronic granulomatous disease (CGD) got BCG infection the treatment would be a tough task. The goal of the proposed research is to observe weather vitamin D supplementation

  • 0 views
  • 19 Mar, 2021
  • 1 location
High Dose Peripheral Blood Stem Cell Transplantation With Post Transplant Cyclophosphamide for Patients With Chronic Granulomatous Disease

Chronic granulomatous disease (CGD) affects white blood cell function. Currently, the only curative treatment is bone marrow transplant to replace the abnormal stem cells with new ones (donor

  • 3 views
  • 26 Apr, 2021
  • 1 location
Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies

This is a standard of care treatment guideline for allogeneic hematopoetic stem cell transplant (HSCT) in patients with primary immune deficiencies.

mesna
bone marrow transplant
stem cell transplantation
granulomatous disease
lymphoproliferative disease
  • 265 views
  • 27 Jan, 2021
  • 1 location
Immune Disorder HSCT Protocol

This study hypothesizes that a reduced intensity immunosuppressive preparative regimen will establish engraftment of donor hematopoietic cells with acceptable early and delayed toxicity in patients with immune function disorders. A regimen that maximizes host immune suppression is expected to reduce graft rejection and optimize donor cell engraftment.

alemtuzumab
g-csf
stem cell transplantation
immunosuppressive
immune suppression
  • 123 views
  • 24 Jan, 2021
  • 2 locations