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Found 27 clinical trials
Embryo Selection by Noninvasive Preimplantation Genetic Test (ESNi-PGT)

The objective of this study is to explore whether non-invasive chromosome screening (NICS) can be used as an effective indicator for embryos selection besides morphology through a multicenter randomized controlled trial, by comparing the differences of live birth rate, pregnancy rate and miscarriage rate between the two groups of embryo …

embryo culture
ovarian hyperstimulation
gonadotrophin releasing hormone analogue
Accepts healthy volunteers
  • 22 Apr, 2022
  • 11 locations
RCT Study to Validate niPGT-A Clinical Benefit. (niPGT-A_RCT)

Chromosomal aneuploidies are linked with spontaneous miscarriages and abnormal offspring in human pregnancies. In addition, some types of aneuploidy are reported to prevent implantation. Thus, there is a need to identify the embryos with highest implantation potential on in vitro fertilization (IVF) programs. Since embryo morphology and kinetics have a …

in vitro fertilization
embryo culture
intracytoplasmic sperm injection
  • 26 Feb, 2022
  • 4 locations
A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma

cerebrospinal fluid (CSF)] The appearance of the tumor cells under the microscope Whether or not there are chromosomal abnormalities in the tumor, and if present, what type (also called

brain tumor
craniospinal irradiation
  • 25 May, 2022
  • 1 location
Efficiency of Comprehensive Chromosomal Testing of Trophectoderm Biopsies of Blastocysts in In Vitro Fertilization

Preimplantation embryo aneuploidy is a major source of adverse outcomes in human reproduction since it leads to implantation failure, early pregnancy loss or severe chromosomal diseases. The risk of embryos aneuploidy is drastically increased after 35 years old. The intra uterine transfer of euploid embryos assessed through such techniques as …

in vitro fertilization
embryo culture
secondary infertility
ovarian stimulation
  • 15 Dec, 2021
  • 5 locations
KISS Study: Kinase Inhibition With Sprycel Start up

Chronic myeloid leukaemia (CML) is due to a chromosomal abnormality in white blood cells which results in abnormal multiplication. CML in its earlier, slower growing chronic phase (CP) is well

kinase inhibitor
  • 20 Mar, 2021
  • 9 locations
The Impact of Infant Formula With Probiotics on Infants Health

trial after informed consent form is signed by the parents. Exclusion criteria included: infants with chronic diarrhea, hemangioma, cerebral hemorrhage, severe asphyxia (stage III), fetal chromosomal

Accepts healthy volunteers
  • 05 May, 2022
  • 1 location
Realization of Sequencing of All Known Human Genes in Case of Detection of Cerebral Renal or Ophthalmological Fetal Malformations During Pregnancy in Order to Make an Etiological Diagnosis and to Precise the Fetal Prognosis

search a chromosomal abnormality by the technique of DNA chip. However, some strongly suggestive signs of a genetic (and not chromosomal) pathology have a very low diagnostic rate with this technique. In

  • 26 Jan, 2021
  • 12 locations
Low-dose Interleukin-2 in Women With Unexplained Miscarriages (FaCIL-2)

The purpose of this study is to demonstrate the ability of low dose IL-2 to stimulate peripheral blood Tregs of women with unexplained repeated early spontaneous miscarriages for development of a therapy to prevent fetal rejection by low dose IL-2.

  • 25 May, 2022
  • 1 location
Fetal Genome Profiling Via Trophoblast Cells

The objective of this study is to utilize trophoblast cells accumulating in the endocervical canal at the beginning of pregnancy for non-invasive prenatal testing. If we are able to validate that trophoblast cells obtained at an early gestational age can be reliably used for prenatal testing, there is great potential …

early pregnancy
Accepts healthy volunteers
  • 10 Aug, 2022
  • 1 location
Decreasing Parental Stress of Caregivers of Infants With Infantile Spasms by Using Telemedicine Technology

This study plans to learn more about how the use of new telemedicine technology can help with parental stress, costs, and overall satisfaction in care. Investigators are studying this in families who have children with a specific seizure type called infantile spasms and being treated with a medication called ACTH …

  • 13 May, 2022
  • 1 location