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Found 33 clinical trials
Clinical Study of PGT-A Versus PGT-A+ERA

Patients who have shown previous implantation failures, despite transferring good quality and chromosomally normal embryos (diagnosed by PGT-A), could have a displaced Window of Implantation (WOI) and consequently, alterations in their endometrial receptivity. The correction of this displacement can improve the results of the Assisted Reproduction Treatments (ART). The ERA …

  • 770 views
  • 26 Jan, 2021
  • 19 locations
Evaluation of the Safety and Efficacy of the Association of Ibrutinib and Daratumumab in Relapsed/Refractory Chronic Lymphocytic Leukemia With p53 Dysfunction

Ibrutinib, a first-in-class Bruton Tyrosine kinase (BTK) inhibitor, has become an established treatment in relapsed/refractory chronic lymphocytic leukemia (CLL). However, despite a considerable improvement of Progression Free Survival (PFS) and Overall Survival (OS) in comparison with historical controls, the prognosis of patients with 17p deletion (del17p) remains a concern, as …

  • 2 views
  • 24 Jan, 2021
  • 41 locations
FETO With Long Tail Balloon for a Treatment of Severe CDH

Congenital diaphragmatic hernia (CDH) has an incidence of 1:2200 to 1:4000 newborns. The survival rate depends on the extent of the lung hypoplasia and pulmonary hypertension. In case of an observed / expected total fetal lung volume ratio (o/e TFLV) ratio of 25% or lower and herniation of the liver …

  • 5 views
  • 22 Jan, 2021
  • 1 location
RCT Study to Validate niPGT-A Clinical Benefit.

Chromosomal aneuploidies are linked with spontaneous miscarriages and abnormal offspring in human pregnancies. In addition, some types of aneuploidy are reported to prevent implantation. Thus, there is a need to identify the embryos with highest implantation potential on in vitro fertilization (IVF) programs. Since embryo morphology and kinetics have a …

in vitro fertilization
embryo culture
discomfort
intracytoplasmic sperm injection
  • 717 views
  • 27 Jan, 2021
  • 21 locations
A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma

cerebrospinal fluid (CSF)] The appearance of the tumor cells under the microscope Whether or not there are chromosomal abnormalities in the tumor, and if present, what type (also called

vincristine
corticosteroids
brain tumor
medulloblastoma
craniospinal irradiation
  • 144 views
  • 22 Feb, 2021
  • 25 locations
Daunorubicin and Cytarabine With or Without Uproleselan in Treating Older Adult Patients With Acute Myeloid Leukemia Receiving Intensive Induction Chemotherapy

This phase II/III trial studies how well daunorubicin and cytarabine with or without uproleselan works in treating older adult patients with acute myeloid leukemia receiving intensive induction chemotherapy. Drugs used in chemotherapy, such as daunorubicin and cytarabine, work in different ways to stop the growth of cancer cells, either by …

methotrexate
blast cells
induction chemotherapy
hydroxyurea
leukapheresis
  • 25 views
  • 05 May, 2021
  • 101 locations
KISS Study: Kinase Inhibition With Sprycel Start up

Chronic myeloid leukaemia (CML) is due to a chromosomal abnormality in white blood cells which results in abnormal multiplication. CML in its earlier, slower growing chronic phase (CP) is well

remission
kinase inhibitor
dasatinib
leukemia
chronic phase chronic myeloid leukemia
  • 636 views
  • 20 Mar, 2021
  • 9 locations
Realization of Sequencing of All Known Human Genes in Case of Detection of Cerebral Renal or Ophthalmological Fetal Malformations During Pregnancy in Order to Make an Etiological Diagnosis and to Precise the Fetal Prognosis

search a chromosomal abnormality by the technique of DNA chip. However, some strongly suggestive signs of a genetic (and not chromosomal) pathology have a very low diagnostic rate with this technique. In

  • 0 views
  • 26 Jan, 2021
  • 12 locations
The Use of Decitabine as Induction Therapy for Acute Myeloid Leukemia With Complex and/or Monosomal Karyotype

about 5-10% patients, the myeloblasts exhibit chromosomal abnormalities (complex and/or monosomal karyotype, CK/MK*) that are associated with refractoriness to conventional chemotherapy and an extremely

remission
decitabine
TP53
blast cells
induction chemotherapy
  • 0 views
  • 07 May, 2021
  • 1 location
Low-dose Interleukin-2 in Women With Unexplained Miscarriages

The purpose of this study is to demonstrate the ability of low dose IL-2 to stimulate peripheral blood Tregs of women with unexplained repeated early spontaneous miscarriages for development of a therapy to prevent fetal rejection by low dose IL-2.

  • 0 views
  • 16 Mar, 2021
  • 3 locations