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Found 38 clinical trials
A Study to Evaluate the Safety and Efficacy of PTC518 in Participants With Huntington's Disease (HD)

The primary goal of this study is to evaluate the safety and pharmacodynamic effects of PTC518 and placebo in participants with HD.

  • 0 views
  • 04 Oct, 2022
  • 4 locations
Evaluating the Efficacy of Dextromethorphan/Quinidine in Treating Irritability in Huntington's Disease

The purpose of this study is to assess efficacy and safety of dextromethorphan/quinidine 20mg/10mg (DM/Q 20mg/10mg) in patients with irritability due to Huntington's disease.

change of medication
Accepts healthy volunteers
chorea
dextromethorphan
  • 47 views
  • 16 Mar, 2022
  • 1 location
Assessing the Symptomatic Benefit of Acoustic Slow Wave Enhancement in Parkinson Disease

The study is a randomized, double-blind, sham-controlled cross-over trial to assess the efficacy as well as safety and tolerability of auditory SWS enhancement on measured outcomes in Parkinson disease (PD) patients with disturbed nighttime sleep. Additionally, the investigators will assess the feasibility and efficacy of auditory slow-wave sleep (SWS) enhancement …

genetic test
cognitive impairment
mild cognitive impairment
treatment regimen
genetic testing
  • 0 views
  • 25 Jan, 2022
  • 1 location
Abnormal Hyperkinetic Movements Post Acute Stroke

related to a stroke and 1 to 4% of strokes are complicated by abnormal movements. These are manifested by a parkinsonian syndrome or conversely by hypercinesia which can take the form of chorea or

  • 0 views
  • 05 Jun, 2022
  • 1 location
Prognosis of Paroxysmal Kinesigenic Choreoathetosis in Korea

The aim of this study is to assess the prognosis of paroxysmal kinesigenic choreoathetosis (PKC) in Korean.

  • 0 views
  • 12 Feb, 2022
Neurobiological Predictors of Huntington's Disease (PREDICT-HD) (PREDICT-HD)

The purpose of this trial is to study early brain and behavioral changes in people who have the gene expansion for Huntington's disease, but are currently healthy and have no symptoms.

chorea
behavioral problems
  • 1 views
  • 11 Feb, 2022
  • 1 location
HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease (HDClarity)

HDClarity will seek at least 1200 research participants at different stages of Huntington's disease (HD). The primary objective is to collect a high quality CSF sample for evaluation of biomarkers and pathways that will enable the development of novel treatments for HD. The secondary objective is to generate a high …

Accepts healthy volunteers
chorea
  • 688 views
  • 06 Jun, 2022
  • 29 locations
Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort

Enroll-HD is a longitudinal, observational, multinational study that integrates two former Huntington's disease (HD) registries-REGISTRY in Europe, and COHORT in North America and Australasia-while also expanding to include sites in Latin America. More than 20,000 participants have now enrolled into the study. With annual assessments and no end date, Enroll-HD …

Accepts healthy volunteers
chorea
  • 1728 views
  • 04 Oct, 2022
  • 205 locations
Biological Sample Collection for Research and Biobanking

The New York Stem Cell Foundation (NYSCF) is performing this research to study different conditions and diseases by using cells from the body (such as skin or blood cells). NYSCF uses these samples to make stem cells and other types of cells, conduct research on the samples, perform genetic testing, …

genetic test
genetic testing
Accepts healthy volunteers
  • 23 views
  • 06 May, 2022
  • 1 location
Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Volunteers

disorders. The disorders include attention deficit disorder, autism, congenital adrenal hyperplasia, childhood-onset schizophrenia, dyslexia, obsessive compulsive disorder, Sydenham's chorea, and Tourette's

obsessive-compulsive disorder
tourette's syndrome
developmental disabilities
autism
psychiatric disorder
  • 566 views
  • 22 Sep, 2022
  • 1 location