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Found 37 clinical trials
Open-Label Rollover Study for Continuing Valbenazine Administration for the Treatment of Chorea Associated With Huntington Disease

This is a Phase 3, open-label study to evaluate the long-term safety and tolerability of valbenazine, and to provide subjects continued access to valbenazine for the treatment of chorea

valbenazine
  • 0 views
  • 27 Apr, 2022
  • 33 locations
Transcranial Ultrasound Therapy of Essential Tremor

Context. Essential tremor (ET) is a common disease, disabling in severe forms and resistant to drug treatment. In patients with severe ET, invasive neurosurgical technique such as deep brain stimulation of the Ventral Intermediate (VIM) nucleus of the thalamus is used. Focused ultrasound therapy, creating a small lesion of VIM …

brain stimulation
depression
movement disorder
MRI
  • 345 views
  • 24 Jan, 2021
  • 1 location
Study of WVE-003 in Patients With Huntington's Disease

This is a Phase 1b/2a multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, PK, and PD of WVE-003 in adult patients with early-manifest HD who carry the targeted single nucleotide polymorphism (SNP) - SNP3.

  • 1 views
  • 26 Jul, 2022
  • 22 locations
OCTA in Mild Cognitive Impairment and Alzheimer's Disease

This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography angiography (OCTA) to assess the structure and function of the retinal microvasculature in persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), Parkinson's Disease (PD) or other neurodegenerative disease, multiple sclerosis, and Huntington's disease.

huntington's chorea
disease or disorder
mild cognitive impairment
neurodegenerative disorders
alzheimer's disease
  • 31 views
  • 25 Jan, 2022
  • 1 location
Risperidone for the Treatment of Huntington's Disease Involuntary Movements

The purpose of this study is to assess the safety and benefit of risperidone for the treatment of chorea (involuntary movements) in Huntington's disease. Risperidone is commonly used in clinical

risperidone
involuntary movements
chorea
  • 105 views
  • 24 Jan, 2022
  • 1 location
Deep Brain Stimulation Treatment for Chorea in Huntington's Disease

Evaluating therapeutic effects of globus pallidus internus (GPi) deep brain stimulation (DBS) on Huntington's disease (HD) patients with chorea; Explore the relationship between

brain stimulation
mental state examination
mini-mental state examination
change of medication
  • 0 views
  • 24 Jul, 2022
  • 1 location
Symptomatic Therapy for Patients With Huntington's Disease

Based on the previous symptomatic treatment of Chinese HD patients, this study intends to further optimize the treatment regimen of Chinese HD patients so as to further improve the prognosis of patients.

risperidone
treatment regimen
  • 0 views
  • 24 Jan, 2022
  • 1 location
Adapted Physical Activity Effect on Abilities and Quality of Life of Huntington Patients and Relatives During Rehab Stay (HUNT'ACTIV)

Intro Huntington's disease is a neurodegenerative disease that affects the brain, inducing a dysfunction and death of the middle spiny striatal projection neurons and a progressive alteration of cognitive and motor functions, and psycho-behavioral problems. There is currently no curative treatment but we know hat a multidisciplinary care can optimize …

behavioral problems
neurological examination
cognitive assessment
  • 0 views
  • 25 Jan, 2022
  • 1 location
A Pilot Study Assessing Impulsivity in Patients With Huntington's Disease on Xenazine (Tetrabenazine)

The purpose of this research study is to see if tetrabenazine, which is commonly used to treat Huntington's Disease (HD), reduces the problems of impulsivity that are common in patients with HD. Investigators will also see how the medicine affects aspects of thinking and mood.

xenazine
tetrabenazine
chorea
  • 0 views
  • 25 Jan, 2022
  • 1 location
Safety and Proof-of-Concept (POC) Study With AMT-130 in Adults With Early Manifest Huntington Disease

This is the first study of AMT-130 in patients with early manifest HD and is designed to establish safety and proof-of-concept (PoC). CT-AMT-130-01 is a Phase I/II, randomized, multicenter, dose escalation, double-blind, imitation surgery, first-in-human (FIH) study.

htt gene
chorea
  • 161 views
  • 17 Feb, 2022
  • 12 locations