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Found 33 clinical trials
Transcranial Ultrasound Therapy of Essential Tremor

Context. Essential tremor (ET) is a common disease, disabling in severe forms and resistant to drug treatment. In patients with severe ET, invasive neurosurgical technique such as deep brain stimulation of the Ventral Intermediate (VIM) nucleus of the thalamus is used. Focused ultrasound therapy, creating a small lesion of VIM …

movement disorder
brain stimulation
MRI
depression
  • 74 views
  • 24 Jan, 2021
  • 1 location
Deep Brain Stimulation (DBS) of the Globus Pallidus (GP) in Huntington's Disease (HD)

The aim of the study is to prove the efficacy and safety of pallidal DBS in HD patients and to show superiority of DBS on motor function in the stimulation group compared to stimulation-off group

brain stimulation
dementia
chorea
  • 0 views
  • 25 Jan, 2021
  • 17 locations
PRidopidine's Outcome On Function in Huntington Disease PROOF- HD

This study will evaluate the efficacy and safety of pridopidine 45mg twice daily (BID) in patients with early stage manifest Huntington Disease (HD).

pridopidine
  • 0 views
  • 22 Jul, 2021
  • 49 locations
OCTA in Mild Cognitive Impairment and Alzheimer's Disease

This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography angiography (OCTA) to assess the structure and function of the retinal microvasculature in persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), Parkinson's Disease (PD) or other neurodegenerative disease, multiple sclerosis, and Huntington's disease.

cognitive impairment
multiple sclerosis
neurodegenerative disorders
huntington's chorea
mild cognitive impairment
  • 8 views
  • 26 Jan, 2021
  • 1 location
A Study of TEV-50717 (Deutetrabenazine) for the Treatment of Dyskinesia in Cerebral Palsy in Children and Adolescents

hyperkinetic movement disorders, namely chorea in Huntington's disease (HD) and tardive dyskinesia (TD). Currently, there is no approved treatment available for Dyskinesia in cerebral palsy (DCP). The

  • 180 views
  • 25 Jul, 2021
  • 79 locations
Risperidone for the Treatment of Huntington's Disease Involuntary Movements

The purpose of this study is to assess the safety and benefit of risperidone for the treatment of chorea (involuntary movements) in Huntington's disease. Risperidone is commonly used in clinical

chorea
involuntary movements
risperidone
  • 0 views
  • 26 Jan, 2021
  • 1 location
Efficacy Safety and Tolerability of Valbenazine for the Treatment of Chorea Associated With Huntington Disease

This is a Phase 3, randomized, double-blind, placebo-controlled study to evaluate the efficacy, safety, and tolerability of valbenazine to treat chorea in subjects with Huntington disease.

valbenazine
chorea
  • 71 views
  • 21 May, 2021
  • 40 locations
Deep Brain Stimulation Treatment for Chorea in Huntington's Disease

Evaluating therapeutic effects of globus pallidus internus (GPi) deep brain stimulation (DBS) on Huntington's disease (HD) patients with chorea Explore the relationship between

  • 0 views
  • 16 Apr, 2021
  • 3 locations
A Pilot Study Assessing Impulsivity in Patients With Huntington's Disease on Xenazine (Tetrabenazine)

The purpose of this research study is to see if tetrabenazine, which is commonly used to treat Huntington's Disease (HD), reduces the problems of impulsivity that are common in patients with HD. Investigators will also see how the medicine affects aspects of thinking and mood.

tetrabenazine
chorea
xenazine
  • 0 views
  • 24 Jan, 2021
  • 1 location
Study of BDNF Pathway Biomarkers in the Cerebrospinal Fluid in Patients With Huntington's Disease

Huntington disease (HD, 1.3/10 000) is an autosomal dominant disease due to an abnormal expansion of CAG triplets in HTT gene. Several pathophysiological mechanisms have been evoked, including an alteration of the signaling pathway of the Brain Derived Neurotrophic Factor (BDNF), a neurotrophic factor involved in the survival of neurons …

chorea
autosomal dominant
htt gene
  • 0 views
  • 28 Jan, 2021
  • 1 location