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Found 24 clinical trials
A Phase II Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas (REGOBONE)

INDICATION Metastatic bone sarcomas: conventional high grade osteosarcoma, Ewing sarcoma of bone, intermediate or high-grade chondrosarcomas and chordomas and

nitrosoureas
glomerular filtration rate
ewing's sarcoma
neutrophil count
cancer chemotherapy
  • 42 views
  • 27 Apr, 2022
  • 18 locations
TAEK-VAC-HerBy Vaccine for Brachyury and HER2 Expressing Cancer

. Stage 2 will enroll either chordoma patients for treatment with TAEK-VAC-HerBy alone, or HER2- positive breast and gastric/gastroesophageal junction cancer patients for combination treatment of TAEK-VAC

lapatinib
erbb2
renal function test
endocrine therapy
primary cancer
  • 13 views
  • 27 Jun, 2022
  • 7 locations
Randomized Carbon Ions vs Standard Radiotherapy for Radioresistant Tumors (ETOILE)

macroscopically uncompleted resected radioresistant tumors. Eligible tumors are axial chordoma (except of base of skull), adenoid cystic carcinoma of head and neck (except of trachea) and sarcomas of any site

  • 23 views
  • 28 Feb, 2022
  • 10 locations
Immune Checkpoint Inhibitor Nivolumab in People With Recurrent Select Rare CNS Cancers

Background More than 130 primary tumors of the central nervous system (CNS) have been identified. Most affect less than 1,000 people in the United States each year. Because these tumors are so rare, there are few proven therapies. This study will test whether the immunotherapy drug nivolumab is an effective …

medulloblastoma
renal function
experimental drug
meningioma
ependymoma
  • 120 views
  • 24 Jul, 2022
  • 11 locations
Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors

The investigational drug to be studied in this protocol, BCA101, is a first-in-class compound that targets both EGFR with TGFβ. Based on preclinical data, this bifunctional antibody may exert synergistic activity in patients with EGFR-driven tumors.

pembrolizumab
programmed cell death 1 ligand 1
immunomodulator
monoclonal antibodies
experimental drug
  • 11 views
  • 25 Jul, 2022
  • 8 locations
Efficacy and Safety of Regorafenib as Maintenance Therapy After First-line Treatment in Patients With Bone Sarcomas (REGOSTA)

This is a randomized, double-blinded, 2 arms study concerning patients with bone sarcoma after the first line therapy. In the first arm, patients will be treated with regorafenib for a maximum of 12 months as maintenance therapy after first line therapy, whereas in the second arm, patients will be treated …

ifosfamide
localized disease
glomerular filtration rate
methotrexate
Accepts healthy volunteers
  • 1 views
  • 23 May, 2022
  • 5 locations
HIFU Ablation of Soft Tissue Sarcoma (SarcAblate)

Around 3,300 people are diagnosed with soft tissue sarcoma (STS) each year in the UK, and a significant proportion of STS diagnoses are in people aged under 30 years. STS can arise from various tissue types and is comprised of over 50 tumour types. Although STS is treated with a …

cancer
soft tissue sarcoma
cancer chemotherapy
  • 5 views
  • 21 Mar, 2022
  • 1 location
Natural History and Biospecimen Acquisition Study for Children and Adults With Rare Solid Tumors

>Chondromyxoid fibroma Chordoma Clear cell renal carcinoma Clear Cell Sarcoma Clear cell sarcoma of kidney Conventional chordoma Dedifferentiated

cns tumor
Accepts healthy volunteers
cancer
solid tumor
  • 36 views
  • 16 Sep, 2022
  • 4 locations
Molecular and Cellular Characterization of Skull Base Tumors

The purpose of the study is to analyze biological samples and genetic material for basic science research investigating the molecular and cellular characterization of skull base tumors.

  • 0 views
  • 01 Feb, 2022
  • 1 location
Children and Adults With Chordoma

Background Chordoma is a rare type of bone cancer. It occurs in the skull base or spine. Researchers want to study people with chordoma in different ways. They

ct scan
cancer
  • 42 views
  • 27 Jul, 2022
  • 1 location