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Found 25 clinical trials
Ion Irradiation of Sacrococcygeal Chordoma

The purpose of this study is to evaluate the safety and feasibility of primary hypofractionated irradiation of sacrococcygeal chordoma with carbon ions or protons using the raster scan technique

  • 4 views
  • 05 Sep, 2021
  • 1 location
Sacral Chordoma: Surgery Versus Definitive Radiation Therapy in Primary Localized Disease (SACRO)

Comparative study on surgery versus definitive radiation therapy in primary localized sacral chordoma

ct scan
proton therapy
antineoplastic
  • 71 views
  • 25 Feb, 2022
  • 12 locations
DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors

>Desmoid tumors Peripheral nerve sheath tumors and NF1-related tumors (closed to accrual 09/19/2018) Malignant giant cell tumors Chordoma (closed to accrual 11/29/2018)

human immunodeficiency virus
thyroidectomy
metastatic malignancy
carcinoid
ovarian cancer
  • 6651 views
  • 22 Oct, 2022
  • 752 locations
CDK4/6 Inhibition in Locally Advanced/Metastatic Chordoma

In chordoma cell lines and patient biopsies, the p16 (CDKN2A) tumor suppressor is consistently deleted. Thus, chordomas are an example of a tumor with universal activation of the cyclin

imatinib
sorafenib
cancer chemotherapy
vasectomy
metastatic chordoma
  • 39 views
  • 07 Jan, 2022
  • 3 locations
Cetuximab for the Treatment of Advanced Unresectable or Metastatic Chordoma

This is a multicenter, single arm, phase 2 study designed to evaluate the efficacy and safety of cetuximab for the treatment of advanced (unresectable)/metastatic, chordoma. The target patient

measurable disease
pet/ct
metastatic chordoma
neutrophil count
gilbert's disease
  • 0 views
  • 18 Jun, 2022
  • 1 location
Trial of Proton Versus Carbon Ion Radiation Therapy in Patients With Chordoma of the Skull Base

This study is a prospective randomised clinical phase III trial. The primary objective of this study is to evaluate, if the innovative therapy (carbon ion irradiation) in chordomas is superior

innovative therapy
proton therapy
  • 47 views
  • 08 Nov, 2020
A Signal Finding Phase 2 Study of Nivolumab (Anti-PD-1; BMS-936558; ONO-4538) and Relatlimab (Anti-LAG-3 Monoclonal Antibody; BMS-986016) in Patients With Advanced Chordoma

This phase II trial studies how well nivolumab and relatlimab work in treating participants with chordoma that has spread to other places in the body. Monoclonal antibodies, such as nivolumab

relatlimab
platelet count
cancer
monoclonal antibodies
tumor cells
  • 12 views
  • 17 Oct, 2022
  • 1 location
Trial of Palbociclib in Second Line of Advanced Sarcomas With CDK4 Overexpression. (PalboSarc)

includes chordoma patients only (19 patients). Palbociclib will be administered orally at a dose of 125 mg once a day for 21 consecutive days followed by 7 rest days to comprise a complete cycle of

serum bilirubin
sarcoma
measurable disease
liver metastasis
neutrophil count
  • 17 views
  • 18 Jun, 2022
  • 19 locations
The TNT Protocol: A Phase 2 Study Using Talimogene Laherparepvec,Nivolumab and Trabectedin as First, Second/Third Line Therapy for Advanced Sarcoma, Including Desmoid Tumor and Chordoma (TNT)

This is a Phase 2 study using talimogene laherparepvec, nivolumab, and trabectedin as first, second or third line therapy for advanced sarcoma, including desmoid tumor and chordoma.

platelet count
kidney function tests
advanced sarcoma
measurable disease
trabectedin
  • 37 views
  • 22 Oct, 2022
  • 1 location
Study of Nivolumab and Ipilimumab in Children and Young Adults With INI1-Negative Cancers

This clinical trial is studying two immunotherapy drugs (nivolumab and ipilimumab) given together as a possible treatment for INI1-negative tumors.

kidney function tests
myelosuppressive chemotherapy
monoclonal antibodies
sarcoma
cancer chemotherapy
  • 7 views
  • 04 Oct, 2022
  • 7 locations