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Found 28 clinical trials
Ion Irradiation of Sacrococcygeal Chordoma

The purpose of this study is to evaluate the safety and feasibility of primary hypofractionated irradiation of sacrococcygeal chordoma with carbon ions or protons using the raster scan technique

  • 4 views
  • 05 Sep, 2021
  • 1 location
Sacral Chordoma: Surgery Versus Definitive Radiation Therapy in Primary Localized Disease

Comparative study on surgery versus definitive radiation therapy in primary localized sacral chordoma

proton therapy
ct scan
antineoplastic
  • 31 views
  • 25 Jan, 2021
  • 31 locations
A Phase II Multicenter Study of the EZH2 Inhibitor Tazemetostat in Adult Subjects With INI1-Negative Tumors or Relapsed/Refractory Synovial Sarcoma

with Sponsor approval (e.g., dedifferentiated chordoma) any solid tumor with an EZH2 GOF mutation including but not limited to Ewing's sarcoma and melanoma Cohort 4 (Closed for enrollment

solid tumour
ewing's sarcoma
extraskeletal myxoid chondrosarcoma
measurable disease
nitrosoureas
  • 2 views
  • 19 Aug, 2021
  • 25 locations
Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

>Desmoid tumors Peripheral nerve sheath tumors and NF1-related tumors (closed to accrual 09/19/2018) Malignant giant cell tumors Chordoma (closed to accrual 11/29/2018)

ultrasound examination
neuroendocrine tumor
adrenal pheochromocytoma
MRI
octreotide
  • 6048 views
  • 24 Sep, 2021
  • 818 locations
Afatinib in Locally Advanced and Metastatic Chordoma

In this phase 2, single arm trial patients with locally advanced or metastatic, pathologically proven, EGFR expressing chordoma will be treated with afatinib. Two cohorts of patients will be

neutrophil count
EGFR
gilbert's disease
metastatic chordoma
metastasis
  • 14 views
  • 16 Jun, 2021
  • 3 locations
Pemetrexed for the Treatment of Chordoma

The purpose of this study is to test the safety and tolerability of pemetrexed administered to people with chordoma. Other purposes of this study are to: find out side effects

  • 0 views
  • 27 Jan, 2021
  • 1 location
Nivolumab and Relatlimab in Treating Participants With Advanced Chordoma

This phase II trial studies how well nivolumab and relatlimab work in treating participants with chordoma that has spread to other places in the body. Monoclonal antibodies, such as nivolumab

neutrophil count
gilbert's disease
metastatic chordoma
metastasis
platelet count
  • 10 views
  • 28 Aug, 2021
  • 1 location
Improvement of Local Control in Skull Base Spine and Sacral Chordomas Treated by Surgery and Protontherapy Targeting Hypoxic Cells Revealed by [18F]FAZA) PET/CT Tracers

Improved local control of chordoma initially treated with surgery or not, thanks to adjuvant radiotherapy oriented by conventional imaging Computed Tomography /Magnetic Resonance Imaging (CT

  • 7 views
  • 11 Apr, 2021
  • 2 locations
Nivolumab With or Without Stereotactic Radiosurgery in Treating Patients With Recurrent Advanced or Metastatic Chordoma

This phase I trial studies the side effects of nivolumab with or without stereotactic radiosurgery (SRS) in treating patients with chordoma that has come back or spread from where it started to

investigational drug
neutrophil count
metastatic chordoma
metastasis
ct scan
  • 14 views
  • 18 Apr, 2021
  • 2 locations
Trial of Proton Versus Carbon Ion Radiation Therapy in Patients With Chordoma of the Skull Base

This study is a prospective randomised clinical phase III trial. The primary objective of this study is to evaluate, if the innovative therapy (carbon ion irradiation) in chordomas is superior

proton therapy
innovative therapy
  • 47 views
  • 08 Nov, 2020