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Found 6 clinical trials
CHIEF PD (CHolinesterase Inhibitor to prEvent Falls in Parkinson's Disease) (CHIEF PD)

has the potential to almost halve the number of falls. This trial aims to definitively determine whether cholinesterase inhibitors (ChEi), can prevent falls in Parkinson's and whether this

dopamine
  • 55 views
  • 07 Oct, 2022
  • 36 locations
Efficacy and Safety of ChOline ALfoscerate in Patient With Mild to Moderate Alzheimer's Disease (COALA)

The purpose of this study is to determine whether combination of donepezil, a cholinesterase inhibitor, with choline alfoscerate has a more favourable clinical profile than monotherapy with donepezil alone.

donepezil
alzheimer's disease
cholinesterase
  • 0 views
  • 08 Jun, 2022
  • 3 locations
tDCS on Parkinson's Disease Cognition (tDCS-PD-fMRI)

dysfunction is one of the most significant factors affecting the quality of life of patients with PD. While dementia in Parkinson's disease is routinely treated by cholinesterase inhibitors (e.g., donepezil

cognitive disorder
cholinesterase inhibitors
cognitive assessment
transcranial direct current stimulation
cholinesterase
  • 169 views
  • 20 Apr, 2022
  • 1 location
Istradefylline for Parkinson Disease With Cognitive Impairment

The purpose of this research study is to determine whether istradefylline improves cognition in individuals with Parkinson disease with cognitive impairment.

carbidopa
cognitive impairment
dementia
carbidopa/levodopa
antiparkinsonian agents
  • 0 views
  • 04 Oct, 2022
  • 1 location
Cortical Excitability in AD-AHeAD

The aim of this study is to understand the relationship between brain excitability, neuroimaging, and cognitive function in early Alzheimer's disease in order to help develop future treatments. Participants are followed over 18 months.

  • 0 views
  • 03 Mar, 2022
  • 1 location
Spinal Cord sTimulation thEraPy for Parkinson's Disease Patients With Gait Problems (STEP-PD)

Gait difficulties are common in Parkinson's disease (PD) and cause significant disability. No treatment is available for these symptoms. Spinal Cord Stimulation (SCS) has been found to improve gait, including freezing of gait, in a small number of PD patients. The mechanism of action is unclear and some patients are …

  • 0 views
  • 05 May, 2022
  • 1 location