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Found 12 clinical trials
Effects of Donepezil HCL on Task-Activated fMRI Brain Activation in Healthy Older Adults at Genetic Risk for Alzheimer's Disease

This study examines the sensitivity of functional MRI to detect brain changes caused by donepezil HCL (a cholinesterase inhibitor) in healthy older adults at genetic risk for Alzheimer's Disease

  • 22 views
  • 02 Apr, 2021
  • 1 location
The Impact of an Epidural Ropivacaine-Neostigmine Injection for Perineal Analgesia at the End of Labor.

cholinesterase inhibitor at a dose of 500µg combined with Sufentanil or Ropivacaine (=local anaesthetic) is an analgesic. The goal of this study is to examine the effect of the use of epidural

  • 13 views
  • 07 Nov, 2020
  • 1 location
Memantine on Aggression and Agitation of Alzheimer's Disease (AD)

noncognitive symptom experienced in patients with dementia. Memantine is a recognized treatment for Alzheimer's disease either alone or in combination with cholinesterase inhibitors. Its efficacy in

agitation
cholinesterase inhibitors
vascular dementia
cholinesterase
demented
  • 13 views
  • 07 Nov, 2020
  • 1 location
Efavirenz for Patients With Alzheimer's Disease

This will be a two-center, placebo controlled blinded clinical trial to evaluate the safety and tolerability of efavirenz (EFV) in 36 clinically stable subjects with mild cognitive impairment/early dementia due to Alzheimer's Disease (AD) age 55 years. Of these 36 total subjects, 18 will be recruited by MGH and 18 …

cognitive decline
neuropsychological test
mild cognitive impairment
cholinesterase inhibitors
mini-mental state examination
  • 1 views
  • 28 Jan, 2021
  • 1 location
CHIEF PD (CHolinesterase Inhibitor to prEvent Falls in Parkinson's Disease)

> Cholinesterase inhibitor (ChEis) are drugs that are currently used to treat people with memory problems in Parkinson's. The effect of these drugs on falls in Parkinson's has been tested to show that treatment

dopamine
  • 1 views
  • 23 Jan, 2021
  • 1 location
Does Higher OT Temperature and IV Ondansetron Reduce Incidence of PSS in Parturients?

This study will look at the incidence of post-spinal shivering (PSS) among the obstetrics population and will investigate whether higher operation theater (OT) temperature range or/and IV Ondansetron are able to reduce the incidence of PSS. This is a double-blind, randomized, factorial study, patients will be grouped into 4 groups …

  • 0 views
  • 28 Jan, 2021
  • 1 location
The LUCINDA Trial: LeUprolide Plus Cholinesterase Inhibition to Reduce Neurological Decline in Alzheimer's

The LUCINDA Trial is a three-site, phase II, randomized, double-blind, placebo-controlled study of leuprolide acetate (Eligard) in women with Alzheimer's Disease taking a stable dose of donepezil (Aricept.) Its objective is to assess the efficacy of a 48-week regimen of leuprolide (22.5 mg per 12 weeks) compared to placebo on …

donepezil
mini-mental state examination
alzheimer's disease
cholinesterase
dementia
  • 41 views
  • 15 Mar, 2021
  • 3 locations
tDCS on Parkinson's Disease Cognition

dysfunction is one of the most significant factors affecting the quality of life of patients with PD. While dementia in Parkinson's disease is routinely treated by cholinesterase inhibitors (e.g., donepezil

cognitive assessment
parkinsonism
donepezil
movement disorder
transcranial direct current stimulation
  • 39 views
  • 24 Jan, 2021
  • 1 location
Senolytic Therapy to Modulate Progression of Alzheimer's Disease

The purpose of this pilot study is to evaluate whether a combination of two drugs, dasatinib (D) and quercetin (Q) [D+Q], penetrate the brain using cerebrospinal fluid (CSF) in older adults with early Alzheimer's disease (AD). This combination of drug therapy has been shown to affect dying cells in humans …

cholinesterase inhibitors
body mass index
progression of alzheimer's disease
alzheimer's disease
cholinesterase
  • 0 views
  • 24 Jan, 2021
  • 1 location
The Effect of Donepezil in Radiotherapy-related Cognitive Impairment.

Purpose: This randomized, double-blind, placebo-controlled clinical trial aims to evaluate the therapeutic effects of donepezil in radiotherapy-related cognitive impairment. Further study details as provided by Sun Yat-sen Memorial Hospital, Sun Yat-sen University / Yameitang. Primary outcome measure: cognitive improvement, which is determined by the difference value of ADAS-cog score before …

cancer
donepezil
mini-mental state examination
  • 0 views
  • 23 Jan, 2021
  • 1 location