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Found 42 clinical trials
A Prospective Database of Infants With Cholestasis (PROBE)

Biliary atresia, idiopathic neonatal hepatitis, and specific genetic cholestatic conditions are the most common causes of jaundice and hyperbilirubinemia that continue beyond the newborn period. The long term goal of the Childhood Liver Disease Research Network (ChiLDReN) is to establish a database of clinical information and plasma, serum, and tissue …

  • 6 views
  • 03 May, 2022
  • 12 locations
Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC) (LOGIC)

Cholestasis is a condition in which bile is not properly transported from the liver to the small intestine. Cholestasis can be caused by an array of childhood diseases, including the genetic

bile salts
alpha1-proteinase inhibitor (human)
bile acid
small intestine
cholestasis
  • 200 views
  • 02 May, 2022
  • 13 locations
Flexible Percutaneous Transhepatic Cholangiopancreatoscopy (PTCS) in Complex Pancreaticobiliary Disease

To document the clinical utility of percutaneous cholangiopancreatoscopy using a thin, disposable, flexible endoscope for evaluation and treatment of complex pancreaticobiliary disease in a prospective, multi-center case series

  • 0 views
  • 14 Oct, 2022
  • 5 locations
Reproductive Endocrinology Oxford Study (RepOx) (RepOx)

; and pregnancy complications such as gestational diabetes mellitus and Intrahepatic cholestasis of pregnancy (ICP). This will be achieved through cross-sectional observation and laboratory analyses.

miscarriage
diabetes
fasting
hyperandrogenism
pregnancy complications
  • 0 views
  • 24 Mar, 2022
Prospective Multicenter Cohort Study on Primary Biliary Cholangitis

The German PBC Cohort is a multi-centric, observational (non-interventional) study with three parallel groups. The main objective of this observational study is to describe the course of Primary biliary cholangitis (PBC) in patients in Germany under routine treatment with approved drugs. Therefore, the effectiveness and safety/tolerability of PBC treatment options …

platelet count
immune globulin
glutaric acid
initial diagnosis
cholangitis
  • 0 views
  • 18 Aug, 2021
  • 41 locations
Los Angeles Prospective GI Biliary and EUS Series

Endoscopic retrograde cholangiopancreatography and endoscopic ultrasound are increasingly being used to manage complex disease of the bile duct, pancreas and cancer. Gastroenterology patients at the Los Angeles County Hospital presents a unique and diverse patient population. Our aim is to study the biochemical, radiographic, and clinical predictors of bile duct …

endoscopic ultrasound
bile leaks
endoscopic retrograde cholangiopancreatography
cancer
cholangitis
  • 59 views
  • 03 Jul, 2022
  • 1 location
Integrated Approaches for Identifying Molecular Targets in Liver Disease (InLi)

To provide a framework for successful clinical trials testing novel targets for therapy in liver disease. To identify molecular and cellular drivers of liver disease to provide a molecular classification and study the determinants or key drivers of disease progression. Consecutive patients admitted with steatohepatitis (alcoholic or non-alcoholic) will be …

liver disease
Accepts healthy volunteers
steatohepatitis
  • 0 views
  • 09 Jul, 2022
  • 1 location
Liver Disease in Pregnancy

Liver Diseases in pregnancy represents rare disorders and current data is derived primarily from single centres and retrospective cohorts. Moreover, the population prevalence of these diseases is low and to-date, it has proven difficult to generate reliable data at a patient level. This is a multi-center, prospective cohort study that …

cirrhosis
liver disease
fatty liver
  • 7 views
  • 13 Feb, 2022
  • 1 location
Prevalence of Liver Disease in Patients Dependent on Parenteral Nutrition (THRIVE-1)

week. Liver disease will be determined by the presence of choline deficiency, cholestasis (confirmed by elevated serum alkaline phosphatase (ALP) liver isoenzyme level), and steatosis (confirmed by

  • 0 views
  • 04 Oct, 2022
  • 8 locations
A Systems Biology Approach for Identification of Host and Microbial Mechanisms and Druggable Targets for the Treatment of PSC-IBD (PSC-Vanc)

) attenuates colonic inflammation and improves biochemical markers of cholestasis in PSC. However, there is no mechanistic data exploring the host-microbial alterations under vancomycin treatment in PSC-IBD

cancer
primary sclerosing cholangitis
enteropathy
colitis
endoscopy
  • 0 views
  • 16 Jun, 2022
  • 1 location