Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 610 clinical trials
This Study Aims to Find the Best Dose of BI 907828 in Patients With Different Types of Advanced Cancer (Solid Tumors)

This study is open to adults with different types of advanced cancer (solid tumors). The purpose of this study is to find out the most suitable dose of BI 907828 the participants can tolerate. The most suitable dose is used in the second part to find out whether BI 907828 …

TP53
advanced cancer
solid neoplasm
measurable disease
primary cancer
  • 57 views
  • 28 Jul, 2022
  • 17 locations
Alberta Cancer Exercise Hybrid Effectiveness-Implementation Study (ACE)

The primary purpose of this proposed 5-year hybrid effectiveness and implementation study is to evaluate the relative benefit from, and implementation of an Alberta wide clinic-to-community-based cancer and exercise model of care - the Alberta Cancer Exercise (ACE) Program. The investigators hypothesize that the strategy will improve the physical well-being …

cancer treatment
primary cancer
  • 16 views
  • 08 Aug, 2022
  • 2 locations
Study of TSR-042, an Anti-programmed Cell Death-1 Receptor (PD-1) Monoclonal Antibody, in Participants With Advanced Solid Tumors (GARNET)

This is a multi-center, open-label, first-in-human Phase 1 study evaluating the anti-programmed death receptor 1 (anti-PD-1) antibody dostarlimab (also known as TSR-042) n participants with advanced solid tumors who have limited available treatment options. The study will be conducted in 2 parts with Part 1 consisting of safety evaluation, pharmacokinetics …

EGFR
x-rays
advanced malignant solid tumor
endocrine therapy
cancer chemotherapy
  • 8 views
  • 23 Apr, 2022
  • 79 locations
Study of REGN3767 (Anti-LAG-3) With or Without REGN2810 (Anti-PD1) in Advanced Cancers

The primary objectives in the dose escalation phase are to evaluate safety and pharmacokinetics (PK) in order to determine the selected dose level(s) for expansion of REGN3767 as monotherapy and in combination with cemiplimab in patients with advanced malignancies, including lymphoma. The primary objectives in the dose expansion phase are …

pd-l1
lymphoma
primary cancer
bone marrow procedure
measurable disease
  • 392 views
  • 26 Apr, 2022
  • 40 locations
A Study Evaluating the Safety, Pharmacokinetics (PK), and Preliminary Efficacy of ABBV-399 in Participants With Advanced Solid Tumors

This is a Phase 1/1b open-label study evaluating the safety, pharmacokinetics (PK), and preliminary efficacy of ABBV-399 as monotherapy and in combination with osimertinib, erlotinib, and nivolumab in participants with advanced solid tumors likely to express c-Met. Enrollment is closed for the monotherapy arms, Arm A, and Arm D.

EGFR
growth factor
primary cancer
bone marrow procedure
treatment regimen
  • 49 views
  • 27 May, 2022
  • 22 locations
A Study of Subcutaneous Nivolumab Monotherapy With or Without Recombinant Human Hyaluronidase PH20 (rHuPH20)

The purpose of this study is to investigate the effects of nivolumab when given under the skin with or without rHuPH20. This study will include participants with 1 of the following advanced or metastatic tumors approved for treatment with nivolumab monotherapy: non-small cell lung cancer (NSCLC) renal cell carcinoma (RCC) …

carcinoma
solid tumor
primary cancer
  • 101 views
  • 23 Jul, 2022
  • 16 locations
First-in-human Single Agent Study of SAR442257 in RRMM and RR-NHL

Primary Objective: To determine the maximum tolerated dose (MTD) of SAR442257 administered as a single agent in patients with relapsed and refractory multiple myeloma (RRMM) and refractory non-Hodgkin lymphoma (RR-NHL), and determine the recommended Phase 2 dose (RP2D) Secondary Objectives: To characterize the safety profile of SAR442257 To characterize the …

primary cancer
dexamethasone
lymphoma
multiple myeloma
measurable disease
  • 29 views
  • 22 Jul, 2022
  • 13 locations
ASIA Down Syndrome Acute Lymphoblastic Leukemia 2016

To evaluate the outcome of a prednisolone and low dose methotrexate based protocol in Down syndrome children with ALL (DS-ALL) in an Asia-wide study. The treatment protocol was modified based upon backbone of Taiwan Pediatric Oncology Group (TPOG)-ALL protocol in which risk classification will be guided by level of flow …

cytarabine
minimal residual disease
residual tumor
methotrexate
lymphoid leukemia
  • 20 views
  • 13 Feb, 2022
  • 6 locations
Durvalumab and Tremelimumab for Pediatric Malignancies

The purpose of the study is to determine the recommended dose of durvalumab and tremelimumab (immunotherapy drugs) in pediatric patients with advanced solid and hematological cancers and expand in a second phase to test the efficacy of these drugs once this dose is determined.

leukemia
lymphoma
durvalumab
acute leukemia
cancer
  • 15 views
  • 08 Aug, 2022
  • 22 locations
Analysis of Circulating Tumor Markers in the Blood (ALCINA)

Exploratory study on blood-borne biological markers and their correlation with clinical and pathological characteristics.

tumor markers
metastasis
anticoagulants
  • 28 views
  • 01 Mar, 2021
  • 6 locations