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Found 703 clinical trials
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Program to Establish the Genetic and Immunologic Profile of Patient's Tumor for All Types of Advanced Cancer

It is a non-randomized, multicentric, cohort study, combined with a biological sample collection, a clinical data collection and with a genetic and immunologic biomarkers study. The ProfiLER program aims to implement a personalized cancer medicine approach by proposing to establish the genetic and immunologic profile of the tumor for patients …

primary cancer
advanced cancer
x-rays
  • 12 views
  • 16 Aug, 2021
  • 8 locations
None
Study of MK-4830 as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-4830-001)

This study has dose escalation (Part A, B, C) and dose expansion (Cohorts A-L) parts. Dose escalation is to evaluate the safety, tolerability, and preliminary efficacy of MK-4830 monotherapy administration (Parts A and B) and in combination with pembrolizumab (Part C). Dose expansion is to evaluate the objective response rate …

carboplatin
antineoplastic agents
cancer chemotherapy
x-rays
metastatic solid tumor
  • 177 views
  • 20 Nov, 2021
  • 28 locations
None
Alberta Cancer Exercise Hybrid Effectiveness-Implementation Study

The primary purpose of this proposed 5-year hybrid effectiveness and implementation study is to evaluate the relative benefit from, and implementation of an Alberta wide clinic-to-community-based cancer and exercise model of care - the Alberta Cancer Exercise (ACE) Program. The investigators hypothesize that the strategy will improve the physical well-being …

primary cancer
cancer treatment
  • 16 views
  • 06 Sep, 2021
  • 2 locations
None
Long-Term Follow-up Protocol for Subjects Treated With Gene-Modified T Cells

This is a prospective study for the long-term follow-up (LTFU) of safety and efficacy for all pediatric and adult subjects exposed to Gene-modified (GM) T cell therapy participating in a previous Celgene sponsored or Celgene alliance partner sponsored study. Subjects who received at least one GM T cell infusion, will …

treatment regimen
  • 153 views
  • 18 Jul, 2021
  • 187 locations
None
A Study to Evaluate the Efficacy and Safety of Bintrafusp Alfa (M7824) Monotherapy in Metastatic or Locally Advanced Urothelial Cancer

The purpose of this study is to evaluate bintrafusp alfa in participants with metastatic or locally advanced urothelial cancer. This trial provides the first evaluation of bintrafusp alfa in participants with urothelial cancer that has progressed following platinum therapy

immunostimulants
primary cancer
metastasis
measurable disease
neutrophil count
  • 0 views
  • 26 Jul, 2021
  • 15 locations
None
First-in-human Study of ATR Inhibitor BAY1895344 in Patients With Advanced Solid Tumors and Lymphomas

The ATR(ataxia-telangiectasia and Rad3 related protein) inhibitor BAY1895344 is developed for the treatment of patients with advanced solid tumors and lymphomas. The purpose of the proposed trial is to evaluate the safety and tolerability of BAY1895344, and to identify the maximum tolerated dose of BAY1895344 that could be safely given …

lymphoma
platelet count
advanced cancer
primary cancer
neutrophil count
  • 10 views
  • 25 Sep, 2021
  • 46 locations
None
A Study of JNJ-70218902 in Participants With Advanced Stage Solid Tumors

The purpose of this study is to determine the recommended Phase 2 dose(s) (RP2D[s]) and maximum tolerated dose (MTD) of JNJ-70218902 in Part 1, and to determine the safety of JNJ-70218902 RP2D(s) in Part 2.

targeted therapy
primary cancer
solid neoplasm
adenocarcinoma
  • 52 views
  • 08 Dec, 2021
  • 11 locations
None
Master Protocol to Assess the Safety and Dose of First Time in Human Next Generation Engineered T Cells in NY-ESO-1 and/or LAGE-1a Positive Advanced Solid Tumors

This trial will evaluate the safety and efficacy of first time in human engineered T-cell therapies, in participants with advanced tumors.

lymphoma
taxane
BRAF
sarcoma
ROS1
  • 0 views
  • 29 Sep, 2021
  • 10 locations
None
This Study Aims to Find and Test a Safe Dose of BI 905677 in Patients With Different Types of Cancer (Solid Tumours)

This study is open to adults with different types of advanced cancer (solid tumours). This study is open to people in whom previous treatments were not successful. The purpose of this study is to find out the highest dose of BI 905677 the participants can tolerate. BI 905677 is a …

growth factor
advanced cancer
gilbert's syndrome
alopecia
primary cancer
  • 16 views
  • 16 Jan, 2022
  • 6 locations
None
A Safety and Efficacy Study of CC-90011 in Combination With Nivolumab in Subjects With Advanced Cancers

This is a Phase 2, multicenter, open-label, multi-cohort study to assess safety and efficacy of CC-90011 in combination with nivolumab in subjects with small cell lung cancer or squamous non-small cell lung cancer who have progressed after 1 or 2 lines of therapies. The primary objectives of the study are …

lung cancer
gilbert's syndrome
blood transfusion
primary cancer
metastasis
  • 0 views
  • 16 Jan, 2022
  • 42 locations