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Found 11 clinical trials
Comparative Effectiveness of Readmission Reduction Interventions for Individuals With Sepsis or Pneumonia (ACCOMPLISH)

An adaptive platform trial to compare effectiveness of different care models to prevent readmissions for patients hospitalized with sepsis or lower respiratory tract infection. The primary outcome is number of days spent at home within 90 days after hospital discharge.

pneumonia
shortness of breath
respiratory tract infection
  • 0 views
  • 01 May, 2022
  • 1 location
A Randomised Controlled Trial in HIV-1 Exposed Ugandan Infants to Estimate Additional Benefits (Non-specific Effects) of BCG

BCG vaccination may have non-specific effects (NSE) i.e., additional benefits on childhood morbidity and mortality that are separate the vaccine's effect on the incidence of disseminated tuberculosis. Though the available literature is mostly from observational study designs, and is fraught with controversy, BCG vaccination at birth, in a high risk …

interleukin-6
bcg vaccine
vaccination
antiretroviral
Accepts healthy volunteers
  • 21 views
  • 22 Sep, 2022
  • 1 location
  • 0 views
  • 15 Sep, 2022
  • 20 locations
A Study in Infants With RSV LRTI to Evaluate RV521 (REVIRAL 1)

This is a multicentre, 3-part study to evaluate safety, tolerability, PK, PD, and antiviral effect of single and multiple dosing of RV521 in infants hospitalised due to Respiratory Syncytial Virus (RSV) lower respiratory tract infection (LRTI). Due to the adaptive study design, the number of enrolled subjects may vary depending …

antiviral
respiratory tract infection
  • 31 views
  • 22 Mar, 2022
  • 32 locations
Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study

This study will seek to enroll immunocompromised patients with Lower Tract parainfluenza infection. It also contains a sub-study to enroll patients with severe COVID-19.

immunodeficiency
cancer
leukemia
stem cell transplantation
respiratory tract infection
  • 2805 views
  • 19 Jun, 2022
  • 40 locations
Protecting Preterm Infants From Respiratory Tract Infections and Wheeze by Using Bacterial Lysates. (PROTEA)

The primary objective of this study is to reduce respiratory tract infections and wheezing in moderate-late preterms in the first year of life by bacterial lysate administration. Next to determine the correlation of biological markers with respiratory symptoms, immune protection and treatment effect.

  • 0 views
  • 05 Mar, 2022
  • 1 location
A Low-Resource Oxygen Blender Prototype for Use in Modified Bubble CPAP Circuits

Purpose: Using a novel oxygen blender prototype with modified bCPAP to manage children 1 month to 5 years of age hospitalized with respiratory distress due to lower respiratory tract infection (LRTI) in low-resource settings is not associated with clinical failure within 1 hour of use. Aim: To investigate if this …

  • 0 views
  • 19 Sep, 2022
  • 1 location
Swallowing, Feeding and Eating in Children Born With Oesophageal Atresia/Trache-oesophageal Fistula (OA/TOF) (SaFE)

is extremely successful, with 90-95% of babies surviving. However, approximately 50-80% of babies will have ongoing feeding or swallowing difficulties resulting in choking, chest infections and

  • 0 views
  • 14 Apr, 2022
  • 1 location
Triage UltraSound in Tb Endemic Regions (TrUST)

In Sub-Saharan Africa, lower respiratory tract infections (LRTIs) and tuberculosis (TB) jointly are the leading cause of overall mortality. There is a need to integrate sustainable triage and management strategies into standard care. The TrUST study investigates the utility of point-of-care ultrasound (POCUS) for diagnosis and prognosis of LRTIs in …

chest pain
shortness of breath
respiratory tract infection
fever
dyspnea
  • 0 views
  • 14 Jul, 2022
  • 2 locations
The Use of Wearable Technology to Acquire Signals for COPD Research

(chest infections or a worsening of the underlying symptoms). Severe COPD exacerbations are the second largest cause of emergency admissions in the UK. Mild and moderate exacerbations can be managed in

obstruction
pulmonary function test
respiratory failure
dyspnea
  • 0 views
  • 08 Oct, 2021
  • 1 location