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Found 214 clinical trials
alloSHRINK - Standard cHemotherapy Regimen and Immunotherapy With Allogeneic NKG2D-based CYAD-101 Chimeric Antigen Receptor T-cells (alloSHRINK)

The purpose of the alloSHRINK study is to assess the safety, cell kinetics and clinical activity of CYAD-101 in patients with unresectable metastatic colorectal cancer administered after standard chemotherapy

metastasis
measurable disease
adenocarcinoma
platelet count
adjuvant chemotherapy
  • 14 views
  • 01 Feb, 2022
  • 2 locations
A Phase 2 Study of the JAK1/JAK2 Inhibitor Ruxolitinib With Chemotherapy in Children With De Novo High-Risk CRLF2-Rearranged and/or JAK Pathway-Mutant Acute Lymphoblastic Leukemia

This is a nonrandomized study of ruxolitinib in combination with a standard multi-agent chemotherapy regimen for the treatment of B-cell acute lymphoblastic leukemia. Part 1 of the study will

lymphoid leukemia
cyclophosphamide
asparaginase
dexamethasone
methotrexate
  • 0 views
  • 28 Oct, 2022
  • 102 locations
Ruxolitinib and Chemotherapy in Adolescents and Young Adults With Ph-like Acute Lymphoblastic Leukemia

This study will test if adding ruxolitinib to standard multi-drug chemotherapy regimen will be safe and tolerated in adolescents and young adults with newly diagnosed Ph-like acute lymphoblastic

blood cell count
cyclophosphamide
vincristine
thioguanine
blast crisis
  • 0 views
  • 27 Sep, 2021
  • 1 location
  • 0 views
  • 24 Apr, 2022
  • 1 location
A Randomized, Open-label, Multi-center Phase IV Study Evaluating Palbociclib Plus Endocrine Treatment Versus a Chemotherapy-based Treatment Strategy in Patients With Hormone Receptor Positive / HER2 Negative Breast Cancer in a Real World Setting (GBG 93 - PADMA Study). (PADMA)

chemotherapy regimen (mono-chemotherapy with or without endocrine therapy). This would provide level 1 evidence from real world that palbociclib plus endocrine therapy is the first choice in MBC patients

tamoxifen
vinorelbine
alopecia
capecitabine
breast cancer
  • 39 views
  • 12 Mar, 2022
  • 1 location
Study of CRS-207, Pembrolizumab, Ipilimumab, and Tadalafil in Metastatic Pancreatic Cancer

progressed after at least 1 prior chemotherapy regimen.

ipilimumab
cancer chemotherapy
pancreatic adenocarcinoma
adenocarcinoma
metastatic pancreatic adenocarcinoma
  • 0 views
  • 04 Oct, 2022
  • 1 location
Pembrolizumab in Combination With Chemotherapy for Patients With Untreated B Cell Lymphoma

This study will research untreated non-germinal center diffuse large B cell lymphoma and what causes the disease and the way patients respond to pembrolizumab combined with R-CHOP chemotherapy

  • 0 views
  • 27 Jan, 2021
  • 1 location
Human BCMA Targeted T Cells Injection Therapy for BCMA-positive Relapsed/Refractory Multiple Myeloma

chemotherapy regimen of fludarabine and cyclophosphamide followed by a single infusion of BCMA CAR+ T cells.

  • 3 views
  • 11 Mar, 2021
  • 3 locations
Low-dose Radiotherapy Plus Chemotherapy With Gem-based Doublets and Stereotactic Radiotherapy for Advanced Pancreatic Cancer

Aim of this study is to evaluate if low-dose radiotherapy (LDR) can intensify local effect of a chemotherapy regimen with Gem-based doublets administered sequentially with stereotactic body

oxaliplatin
adenocarcinoma
platelet count
stereotactic body radiation therapy
obstruction
  • 13 views
  • 28 Jan, 2021
  • 1 location
A Phase Ib Study of the Combination of Venetoclax With Chemotherapy as Frontline Therapy in Older Patients and Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia

This research study is studying a medication called Venetoclax and a chemotherapy regimen as a possible treatment for Acute Lymphoblastic Leukemia. The drugs involved in this study are

lymphoid leukemia
cyclophosphamide
dexamethasone
methotrexate
mercaptopurine
  • 3 views
  • 22 Oct, 2022
  • 3 locations