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Found 182 clinical trials
Cediranib Maleate and Olaparib or Standard Chemotherapy in Treating Patients With Recurrent Platinum-Resistant or -Refractory Ovarian Fallopian Tube or Primary Peritoneal Cancer

treated with platinum-based chemotherapy drugs (platinum-refractory). Cediranib maleate and olaparib may stop the growth of tumor cells by blocking enzymes needed for cell growth. Drugs used in

bevacizumab
ascites
cancer
paclitaxel
absolute neutrophil count
  • 1729 views
  • 13 Jun, 2021
  • 212 locations
Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors

transplant stops the growth of cancer cells by stopping them from dividing or killing them. Giving colony-stimulating factors, such as filgrastim or pegfilgrastim, and certain chemotherapy drugs, helps stem

pegfilgrastim
high-dose chemotherapy
teratoma
cancer
paclitaxel
  • 803 views
  • 13 Jun, 2021
  • 94 locations
De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage HPV-Positive Non-Smoking Associated Oropharyngeal Cancer

cells and shrink tumors. Chemotherapy drugs, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them

bilateral oophorectomy
ct scan
cavity
oropharyngeal
tumor cells
  • 16 views
  • 13 Jun, 2021
  • 225 locations
CompassHER2-pCR: Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy

cells to grow are blocked and the tumor cell may be marked for destruction by the body's immune system. Giving paclitaxel, trastuzumab, and pertuzumab may enable fewer chemotherapy drugs to be given

chemotherapy drug
ejection fraction
estrogen
paclitaxel
tumor cells
  • 43 views
  • 10 May, 2021
  • 493 locations
PHASE III RANDOMISED TRIAL TO EVALUATE FOLFOX WITH OR WITHOUT DOCETAXEL (TFOX) AS 1st LINE CHEMOTHERAPY FOR LOCALLY ADVANCED OR METASTATIC OESOPHAGO-GASTRIC CARCINOMA

advanced stages of gastric or gastro-oesophageal junction adenocarcinoma, the combination of 2 chemotherapy drugs (dual therapy) as compared with monotherapy or no chemotherapy, makes it possible to

  • 11 views
  • 26 Jan, 2021
  • 149 locations
To Reduce the Use of Chemotherapy in Postmenopausal Patients With ER-positive and HER2-positive Breast Cancer (TOUCH)

This is a phase II open-label, multicentre, randomized trial. The study assesses the treatment of postmenopausal patients with hormone receptor positive/HER2 positive early breast cancer with neoadjuvant palbociclib in combination with hormonal therapy and HER2 blockade, versus the treatment with paclitaxel in combination with HER2 blockade.

erbb2
endocrine therapy
cancer
estrogen
paclitaxel
  • 17 views
  • 11 May, 2021
  • 63 locations
Drug-Related Problems in Neonatal Patients

Drug-related problems in newborn babies have been reported with a rate of 4-30%. It is estimated that the higher rates of these problems in hospitalized children under the age of two are related to the variety of drugs used and the differences in the age, weight and diagnosis of the …

  • 0 views
  • 30 May, 2021
  • 1 location
Testing the Combination of Two Approved Chemotherapy Drugs and Radiation Prior to Surgery in Localized Pancreatic Cancer

The purpose of this phase 2 research study is to determine whether a combination of chemotherapy drugs plus radiation therapy, given before surgery in resectable pancreactic cancer, can help to

paclitaxel
gemcitabine
chemotherapy drug
antibiotics
cancer
  • 0 views
  • 13 Jun, 2021
  • 1 location
Testing the Addition of an Anti-cancer Drug KRT-232 (AMG 232) to the Usual Treatments (Cytarabine and Idarubicin) in Patients With Acute Myeloid Leukemia

This phase Ib trial studies the side effects and best dose of KRT-232 (AMG 232) when given together with the standard chemotherapy drugs cytarabine and idarubicin in patients with acute myeloid

venetoclax
gilbert's syndrome
cytarabine
ejection fraction
cancer
  • 0 views
  • 13 Jun, 2021
  • 2 locations
Intrathecal Rituximab With Standard Intrathecal Prophylaxis to Prevent CNS Relapse for CD 20+ Non Hodgkin Lymphoma

The purpose of this research study is to learn if giving rituximab, the study drug, right into the spinal canal along with chemotherapy drugs like methotrexate is possible and safe.

chop regimen
rituximab
large b-cell lymphoma
hodgkin's disease
diffuse large b-cell lymphoma
  • 1 views
  • 23 Jan, 2021
  • 1 location