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Found 181 clinical trials
Clinical Trial Evaluating FOLFIRI + Durvalumab vs FOLFIRI + Durvalumab and Tremelimumab in Second-line Treatment of Patients With Advanced Gastric or Gastro-oesophageal Junction Adenocarcinoma

Gastric adenocarcinoma is the 4th most frequent cancer and the 2nd leading cause of cancer mortality. Most of the patients have metastatic, locally advanced or recurrent unresectable disease. So, systemic treatment remains an important issue especially since chemotherapy improves survival and quality of life (compared to best supportive care alone). …

adenocarcinoma
ipilimumab
avelumab
programmed cell death 1 ligand 1
gastric adenocarcinoma
  • 6 views
  • 26 Jan, 2021
  • 6 locations
Garlic in Patients With Febrile Neutropenia

To determine the clinical effects of garlic in preventing and treatment of patients with chemotherapy related febrile neutropenia.These patients have a very high incidence of infections which are not routinely covered by the standard empiric therapy. Adding a non- toxic and possibly effective therapy may reduce the risk for infections, …

antibiotic therapy
febrile neutropenia
antibiotics
  • 28 views
  • 07 Nov, 2020
  • 1 location
Increasing Linkage to Family Planning Care for Individuals With Substance Use Disorder

This study will utilize mixed methods to develop and assess the feasibility and acceptability of a health educator intervention designed to connect patients in recovery from substance use disorder to reproductive health education and services.

substance use
substance use disorders
behavioral therapy
opioid
opioid use
  • 0 views
  • 22 Mar, 2021
  • 1 location
Induction Chemotherapy Combined With Immunotherapy for Locally Advanced Hypopharyngeal Carcinoma

This is a single-center, multidisciplinary, open-label, single-arm prospective clinical study.

chemotherapy regimen
camrelizumab
carcinoma
creatinine clearance rate
capecitabine
  • 0 views
  • 25 Jan, 2021
  • 1 location
Auricular Acupressure : Improves Oxaliplatin-induced Peripheral Neuropathy

Oxaliplatin-induced peripheral neuropathy (OIPN) is a common adverse effect that becomes worse as the drug dose accumulation impacts cancer patients' daily activities and quality of life.The result of this study will determine the immediate effects of the 8-week auricular acupuncture intervention on alleviating the participants' OIPN symptoms and enhancing their …

  • 0 views
  • 19 Feb, 2021
  • 1 location
FLOT Combined With PD-1 in the First-line Treatment of Patients With Advanced Gastric Cancer and Peritoneal Metastasis

In this study, patients with advanced gastric adenocarcinoma whose peritoneal metastasis and peritoneal nodule pathologically confirmed metastasis and/or exfoliative cytology were confirmed as the clinical stage of peritoneal metastasis, who had not received treatment before, were invited to participate in the study.To evaluate the surgical conversion rate and tumor regression …

adenocarcinoma
leucovorin
gastric adenocarcinoma
oxaliplatin
endoscopic biopsy
  • 0 views
  • 19 May, 2021
  • 1 location
Use of a GLP-1R Agonist to Treat Opioid Use Disorder

This research is being done to find out if liraglutide (brand name is Saxenda) can safely and effectively reduce craving for opioids in patients with opioid use disorder, a primary factor contributing to early relapse.

  • 0 views
  • 01 Apr, 2021
  • 1 location
Orally Fludarabine Adriamycin and Dexamethasone (FAD) in Newly Diagnosed Peripheral T-cell Lymphomas (PTCL)

The primary objective of this study is to evaluate the efficacy of Fludarabine, Adriamycin and Dexamethasone (FAD) as first line therapy in patients with Peripheral T-cell lymphomas (PTCL). 30 patients will be treated into this study.

angioimmunoblastic t-cell lymphoma
fludarabine
neutrophil count
large cell lymphoma
absolute neutrophil count
  • 19 views
  • 07 Nov, 2020
  • 1 location
Dextromethorphan Memantine Monotherapy or Combined Use of Dextromethorphan and Memantine in Amphetamine Addiction

The investigators will conducted a randomized double-blind placebo-controlled study to investigate the treatment outcomes of add-on low dose dextromethorphan (DM), memantine (MM), or dextromethorphan and memantine combination (DM+MM) in amphetamine-type stimulants use disorder patients.

  • 0 views
  • 26 Jan, 2021
  • 1 location
Study of the Therapeutic Response and Survival of Patients With Metastatic Colorectal Cancer (Stage IV) and Treated According to the Guidelines of a Chemosensitivity Test Oncogramme (ONCOGRAM)

Currently, chemotherapies are empirically administered to patients treated for colorectal cancer (CRC). Selection is based on the efficacy of a protocol previously determined on the largest number (consensus treatment), the decision-making process being weighted by patient's intrinsic criteria. However, each patient is unique, due to the inter- and intratumoral heterogeneity …

chemotherapy regimen
adenocarcinoma
folfiri regimen
fluorouracil
folfirinox
  • 14 views
  • 18 Mar, 2021
  • 15 locations