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Found 180 clinical trials
Talazoparib an Oral PARP Inhibitor in Patients With Advanced Solid Tumors and Aberrations in Genes Involved in DNA Damage Response

Background People with advanced cancer are usually treated with surgery, radiation, immunotherapy drugs, or chemotherapy drugs. Talazoparib is a type of drug

  • 0 views
  • 13 Jan, 2021
  • 1 location
Anti-CD22 Chimeric Receptor T Cells in Pediatric and Young Adults With Recurrent or Refractory CD22-expressing B Cell Malignancies

removed. The rest of the blood is returned by needle in the other arm. The cells will be changed in a laboratory. Participants will get two IV chemotherapy drugs over 4 days. Some

ejection fraction
leukemia
chemotherapy drugs
PCR test
lymphoma
  • 31 views
  • 03 Jun, 2021
  • 1 location
Hepatic Artery Infusion Pump Chemotherapy With Floxuridine and Dexamethasone in Combination With Systemic Chemotherapy for Patients With Colorectal Cancer Metastatic to the Liver

Background Many people with colorectal cancer get liver metastases. Standard treatment for this is a combination of chemotherapy drugs. Directing the chemotherapy

chemotherapy drugs
metastatic colorectal cancer
blood test
hepatic arterial infusion
cancer
  • 91 views
  • 24 May, 2021
  • 1 location
Pembrolizumab With Intratumoral Injection of Clostridium Novyi-NT

chemicals that are poisonous to humans, but are still able to cause tumor cells to break down and die. The idea is that these bacteria may be able to assist chemotherapy drugs in fighting cancer.

tumor cells
metastasis
chemotherapy drugs
serum total bilirubin
lung cancer
  • 57 views
  • 24 Jan, 2021
  • 1 location
Carboplatin Nab-Paclitaxel Durvalumab Before Surgery and Adjuvant Therapy in Head and Neck Squamous Cell Carcinoma

Durvalumab with 2 chemotherapy drugs will be effective in treating SCCHN. Durvalumab on its own has been studied in patients with SCCHN and initial results have shown that some subjects' cancer has responded

paclitaxel
renal function test
induction chemotherapy
carcinoma of the head and neck
durvalumab
  • 101 views
  • 24 Jan, 2021
  • 2 locations
HERV-E TCR Transduced Autologous T Cells in People With Metastatic Clear Cell Renal Cell Carcinoma

> Participants cells will be grown in the lab and genetically changed. Participants will stay in the hospital 2-3 weeks. There they will: Get 2 chemotherapy drugs by catheter (thin plastic

tumor cells
hla-a
antibiotics
chemotherapy drugs
cancer
  • 73 views
  • 23 Jun, 2021
  • 1 location
Lenalidomide Combined With Modified DA-EPOCH and Rituximab (EPOCH-R2) in Primary Effusion Lymphoma or KSHV-associated Large Cell Lymphoma

chemotherapy drugs may be effective in treating PEL. Objective To test a new treatment for PEL. Eligibility People ages 18 and older

chemotherapy drugs
methotrexate
filgrastim
doxorubicin
prednisone
  • 9 views
  • 19 Jun, 2021
  • 1 location
CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory CD19/CD22-expressing B Cell Malignancies

> Participants will stay in the hospital about 2 weeks. There they will get: Two chemotherapy drugs by IV Their changed cells by IV Standard drugs for side effects Participants will

cyclophosphamide
chemotherapy drugs
graft versus host disease
cancer
cell transplantation
  • 42 views
  • 01 May, 2021
  • 1 location
A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas

This is a study to determine the safety and efficacy of the drug, mebendazole, when used in combination with standard chemotherapy drugs for the treatment of pediatric brain tumors. Mebendazole

pleomorphic xanthoastrocytoma
chemotherapy drugs
temozolomide
complete resection
carboplatin
  • 218 views
  • 13 Mar, 2021
  • 1 location
CD30 CAR T Cells Relapsed CD30 Expressing Lymphoma (RELY-30)

functions, and that this may not happen if there are too many other T cells in circulation. Because of that, doctors may use chemotherapy drugs to decrease the level of circulating T cells prior to the CD30

tumor cells
autograft
chemotherapy regimen
chemotherapy drugs
fludarabine
  • 42 views
  • 22 Jun, 2021
  • 2 locations