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Found 81 clinical trials
Neoadjuvant Therapy Study Guided by Drug Screening in Vitro for Human Epidermal Growth Factor Receptor 2 (HER2) Negative Early Breast Cancer Patients

unknown for a patient who could benefit from which drug before chemotherapy. Drug sensitivity screening in vitro was a promising method for choosing chemotherapy. But there was no method could select

  • 0 views
  • 19 Apr, 2022
  • 1 location
Ribociclib in Combination With Everolimus and Dexamethasone in Relapsed ALL

This research study is evaluating a drug called ribociclib (LEE011) given in combination with everolimus and other standard of care chemotherapy drugs as a possible treatment for relapsed or refractory ALL. The names of the drugs involved in this study are: ribociclib everolimus dexamethasone

  • 13 views
  • 23 Mar, 2022
  • 8 locations
T-DM1 and Tucatinib Compared With T-DM1 Alone in Preventing Relapses in People With High Risk HER2-Positive Breast Cancer, the CompassHER2 RD Trial

cancer. T-DM1 is a monoclonal antibody, called trastuzumab, linked to a chemotherapy drug, called DM1. Trastuzumab is a form of targeted therapy because it attaches to specific molecules (receptors) on

  • 1 views
  • 22 Mar, 2022
  • 541 locations
Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents

of dosing a chemotherapy drug called pegaspargase (which is part of the standard treatment for ALL) based on checking levels of the drug in the blood and adjusting the dose based on the levels.

corticosteroids
adult t-cell leukemia/lymphoma
pegaspargase
dasatinib
lymphoid leukemia
  • 12 views
  • 26 Mar, 2022
  • 7 locations
A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

longer and could be less likely to cause heart problems than traditional anthracycline drugs, a common class of chemotherapy drug. Some acute myeloid leukemia patients have an abnormality in the

anthracyclines
gemtuzumab
blast cells
cytarabine/daunorubicin
methotrexate
  • 141 views
  • 10 May, 2022
  • 98 locations
A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma

treated with a lower dose of radiation to the brain and spine, and a lower dose of the chemotherapy drug cyclophosphamide while still achieving the same survival rate as past St. Jude studies with fewer

cyclophosphamide
corticosteroids
vincristine
craniospinal irradiation
medulloblastoma
  • 144 views
  • 11 May, 2022
  • 18 locations
Testing the Addition of the Chemotherapy Drug Lomustine (Gleostine®) to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Methylated Glioblastoma

This phase III trial compares the effect of adding lomustine to temozolomide and radiation therapy versus temozolomide and radiation therapy alone in shrinking or stabilizing newly diagnosed MGMT methylated glioblastoma. Chemotherapy drugs, such as lomustine and temozolomide, work in different ways to stop the growth of tumor cells, either by …

temozolomide
immunohistochemistry
neutrophil count
lomustine
tumor resection
  • 0 views
  • 26 Apr, 2022
  • 34 locations
FIGO 2018 Stage IB2 Cervical Cancer Treated With Neoadjuvant Chemotherapy Followed by Fertility Sparing Surgery

invasive cervical cancer. The neo-adjuvant chemotherapy will consist of a platinum-based chemotherapy drug cisplatin or carboplatin, with a chemotherapy drug called paclitaxel. These are common

chemotherapy drugs
immunomodulator
chemotherapeutic agent
invasive cervical cancer
paclitaxel
  • 0 views
  • 09 Oct, 2021
  • 3 locations
Combination of Temozolomide and Sunitinib in Treatment of Patients With Metastatic and Unresectable Malignant Melanoma

The purpose of this study is to determine the safety and efficacy of the treatment with a combination of chemotherapy drug, temozolomide with a drug-blocking blood vessel formation

advanced melanoma
temozolomide
  • 23 views
  • 07 Nov, 2020
  • 1 location
A Study of LY2880070 and Gemcitabine in People With Ewing Sarcoma or Ewing-Like Sarcoma

The purpose of this study is to find out whether LY2880070 combined with the chemotherapy drug gemcitabine is an effective treatment for Ewing sarcoma or Ewing-like sarcoma.

  • 0 views
  • 10 May, 2022
  • 1 location