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Found 76 clinical trials
Neoadjuvant Therapy Study Guided by Drug Screening in Vitro for Human Epidermal Growth Factor Receptor 2 (HER2) Negative Early Breast Cancer Patients

unknown for a patient who could benefit from which drug before chemotherapy. Drug sensitivity screening in vitro was a promising method for choosing chemotherapy. But there was no method could select

  • 0 views
  • 19 Apr, 2022
  • 1 location
T-DM1 and Tucatinib Compared With T-DM1 Alone in Preventing Relapses in People With High Risk HER2-Positive Breast Cancer, the CompassHER2 RD Trial

cancer. T-DM1 is a monoclonal antibody, called trastuzumab, linked to a chemotherapy drug, called DM1. Trastuzumab is a form of targeted therapy because it attaches to specific molecules (receptors) on

  • 1 views
  • 22 Mar, 2022
  • 541 locations
Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents

of dosing a chemotherapy drug called pegaspargase (which is part of the standard treatment for ALL) based on checking levels of the drug in the blood and adjusting the dose based on the levels.

doxorubicin
dasatinib
etoposide
lymphoblasts
corticosteroids
  • 26 views
  • 20 Jun, 2022
  • 9 locations
A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

longer and could be less likely to cause heart problems than traditional anthracycline drugs, a common class of chemotherapy drug. Some acute myeloid leukemia patients have an abnormality in the

cell transplantation
cancer
blast cells
daunorubicin
gemtuzumab
  • 141 views
  • 10 May, 2022
  • 98 locations
A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma

treated with a lower dose of radiation to the brain and spine, and a lower dose of the chemotherapy drug cyclophosphamide while still achieving the same survival rate as past St. Jude studies with fewer

cancer
residual tumor
craniospinal irradiation
brain tumor
medulloblastoma
  • 144 views
  • 25 May, 2022
  • 1 location
Testing the Addition of the Chemotherapy Drug Lomustine (Gleostine®) to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Methylated Glioblastoma

This phase III trial compares the effect of adding lomustine to temozolomide and radiation therapy versus temozolomide and radiation therapy alone in shrinking or stabilizing newly diagnosed MGMT methylated glioblastoma. Chemotherapy drugs, such as lomustine and temozolomide, work in different ways to stop the growth of tumor cells, either by …

lomustine
tumour resection
flair
stereotactic biopsy
beam radiation
  • 0 views
  • 26 Apr, 2022
  • 34 locations
A Phase II Study of Oral CHK1 Inhibitor LY2880070 in Combination With Low-Dose Gemcitabine in Patients With Relapsed or Refractory Ewing Sarcoma

The purpose of this study is to find out whether LY2880070 combined with the chemotherapy drug gemcitabine is an effective treatment for Ewing sarcoma or Ewing-like sarcoma.

  • 0 views
  • 15 Sep, 2022
  • 1 location
FIGO 2018 Stage IB2 Cervical Cancer Treated With Neoadjuvant Chemotherapy Followed by Fertility Sparing Surgery

invasive cervical cancer. The neo-adjuvant chemotherapy will consist of a platinum-based chemotherapy drug cisplatin or carboplatin, with a chemotherapy drug called paclitaxel. These are common

immunomodulator
chemotherapeutic agent
adenocarcinoma
invasive cervical cancer
carboplatin
  • 0 views
  • 09 Oct, 2021
  • 3 locations
Combination of Temozolomide and Sunitinib in Treatment of Patients With Metastatic and Unresectable Malignant Melanoma

The purpose of this study is to determine the safety and efficacy of the treatment with a combination of chemotherapy drug, temozolomide with a drug-blocking blood vessel formation

temozolomide
advanced melanoma
  • 23 views
  • 07 Nov, 2020
  • 1 location
  • 293 views
  • 21 Apr, 2022
  • 6 locations