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Found 42 clinical trials
Anlotinib Combined With Dose-reduced Olaparib in Patients With Platinum-Sensitive Recurrent Ovarian Cancer

PARP inhibitors have changed the treatment paradigm of ovarian cancer. Most patients using PARP(poly-ADP ribose polymerase) inhibitors will suffer different grades of adverse events(AEs), followed by dose reduction. It has not been reported whether the dose-reduced olaparib as maintenance treatment have an impact on efficacy. Both PAOLA-1 and AVANOVA 2 …

kinase inhibitor
cancer chemotherapy
chemotherapy regimen
  • 27 Jan, 2021
  • 1 location
Precision Dosing of Busulfan in Children Undergoing HSCT

The objective of this clinical trial is to evaluate the personalization the conditioning regimen prior to the hematopoietic stem cell transplant (HSCT) in children and adolescents, to improve HSCT efficacy while reducing conditioning-related toxicities. Namely, we are going to compare the accuracy of two methods for determining the first dose …

  • 11 Aug, 2021
  • 1 location
Individualized Response Assessment to Heated Intraperitoneal Chemotherapy (HIPEC) for the Treatment of Peritoneal Carcinomatosis From Ovarian, Colorectal, Appendiceal, or Peritoneal Mesothelioma Histologies

Background Cytoreductive surgery (CRS) removes tumors in the abdomen. HIPEC is heated chemotherapy that washes the abdomen. CRS and HIPEC may help people with peritoneal carcinomatosis. These are tumors that have spread to the lining of the abdomen from other cancers. Researchers think they can improve results of CRS and …

cytoreductive surgery
absolute neutrophil count
  • 28 Oct, 2022
  • 1 location
Comparing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) Using Mitomycin-C Versus Melphalan for Colorectal Peritoneal Carcinomatosis

The purpose of this trial is to compare the morbidity and mortality of CRS-HIPEC using mitomycin-C versus melphalan for colorectal peritoneal carcinomatosis. Morbidity and mortality will measured using the Comprehensive Complication Index (CCI) score, Common terminology criteria for adverse events (CTCAE version 4.03), and the Clavien-Dindo Classification.

neutrophil count
systemic chemotherapy
hyperthermic intraperitoneal chemotherapy
  • 17 Jun, 2022
  • 1 location
Cisplatin Combined With Oral TS-1 in Patients With Advanced Solid Tumors With Different Degrees of Liver Dysfunction

The purpose of this study is to formally characterize the pharmacokinetics (PK), safety, and tolerability of TS-1 in combination with cisplatin in adult patients with advanced solid tumors who have mild, moderate or severe hepatic impairment relative to patients with normal hepatic function, as categorized by the United States National …

primary cancer
renal function test
serum pregnancy test
bone marrow procedure
  • 03 May, 2022
  • 2 locations
Micro Needle Array-Doxorubicin (MNA-D) in Patients With Cutaneous T-cell Lymphoma (CTCL) (MNA-D)

The study hypothesis is that in situ MNA-directed chemo-immunotherapy using doxorubicin will kill tumor cells locally and alter the tumor microenvironment to induce durable systemic tumor-specific immunity. The purpose of this study is to test a new method of experimental treatment for CTCL, using small adhesive-like patches (a micro-needle applicator …

skin biopsy
bexarotene capsules
cutaneous t-cell lymphoma
  • 15 Jun, 2022
  • 1 location
Combination of Temozolomide and Sunitinib in Treatment of Patients With Metastatic and Unresectable Malignant Melanoma

The purpose of this study is to determine the safety and efficacy of the treatment with a combination of chemotherapy drug, temozolomide with a drug-blocking blood vessel formation, sunitinib malate in patients with advanced melanoma..

advanced melanoma
  • 07 Nov, 2020
  • 1 location
Comparison of the Efficacy and Safety of Continuous and Single-Dose Intravesical Epirubicin Instillation

In this study, the local and systemic side effects, tumor recurrens and progression rates of single or continuous epirubicin instillation during the early postoperative period were investigated in low and intermediate risk non-muscle-invasive bladder cancer.

transurethral bladder excision
bladder tumor
transurethral resection
invasive bladder cancer
  • 04 Oct, 2022
  • 1 location
Heated Intraperitoneal Chemotherapy in Primary Ovarian Cancer Patients

This study will evaluate the use of Heated Intraperitoneal Chemotherapy (HIPEC) for primary treatment of ovarian cancer at the time of surgical debulking, to assess if intravenous (IV) chemotherapy can be started within 42 days of HIPEC and cytoreduction. All patients will receive cytoreductive surgery followed by a one-time closed …

clear cell adenocarcinoma
serous cystadenocarcinoma
cancer chemotherapy
ovarian cancer
  • 25 Mar, 2022
  • 1 location
Treatment of Radiation and Cisplatin Induced Toxicities With Tempol

A 10 week trial to assess the ability of Tempol to prevent and/or reduce toxicities associated with cisplatin and radiation treatment in head and neck cancer patients. Over the course of the 10 week trial, mucositis, nephrotoxicity, and ototoxicity will be monitored and assessed.

head and neck cancer
squamous cell carcinoma of the head and neck
absolute neutrophil count
squamous cell carcinoma
neck cancer
  • 25 Mar, 2022
  • 8 locations