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Found 753 clinical trials
Pacing to Maintain Physiologic Ventricular Activation

Right ventricular pacing causes ventricular dyssynchrony and may be associated with impaired outcome. In the last decade, several approaches for more physiological pacing became available and were implemented in the latest guidelines. However, compared to conventional device implantation, cardiac resynchronization, His bundle pacing and left bundle area pacing remain demanding …

cardiac resynchronization therapy
  • 16 Dec, 2021
  • 1 location
Olfactory Change After Chemo-radiotherapy for Nasopharyngeal Carcinoma

This is an observational cohort study aimed to explore the changes of olfactory function at multiple time points from baseline to 1 year after radiotherapy among the local advanced nasopharyngeal carcinoma patients.

nasopharyngeal carcinoma
induction chemotherapy
chemotherapy regimen
  • 22 Mar, 2022
  • 1 location
Whole-Heart Myocardial Blood Flow Quantification Using MRI

This study hopes to provide significant technical improvement in a Myocardial Blood Flow (MBF) cardiac magnetic resonance (CMR) quantification technique to address challenges and technical limitations for MBF CMR. By developing and validating novel techniques to improve first-pass perfusion (FPP) cardiac MR, we propose to increase diagnostic accuracy by minimizing …

Accepts healthy volunteers
arterial disease
myocardial perfusion imaging
  • 25 Feb, 2022
  • 1 location
Real-world Study on Comprehensive Treatment of Esophageal Cancer Based on Precision Radiotherapy

Radiotherapy is one of the main treatments for locally advanced esophageal carcinoma (EC). The accuracy of the existing imaging methods in diagnosing and predicting therapeutic efficacy is disappointing, which increases the difficulty in clinical decision-making. In this study, based on a continuous cohort of EC treated with radiotherapy, the clinical …

  • 11 Oct, 2022
  • 1 location
Detection of Peritoneal Metastasis of Gastric Cancer by Liquid Biopsy in Peripheral Blood: A Prospective Study

This study is a prospective, multi-omics, observational study aimed at detecting peritoneal metastasis of gastric cancer by combined assays for methylation of cell-free DNA (cfDNA) and other blood-based biomarkers. The study will enroll 384 participants with gastric cancer.

primary cancer
  • 12 May, 2022
MRI-guided Lateral Lymph Node Dissection in Rectal Cancer

To investigate the oncological outcome of lateral lymph node dissection in low rectal cancer based on MRI

  • 07 May, 2021
  • 1 location
Wearable Remote Monitoring of Heart Rate and Respiratory Rate for Heart Failure

The primary objective of this study is to study in heart failure (HF) patients to better assess HF disease state, which can aid in management and improve outcomes. Primary aims of the study include: (1) Measure HR and RR at rest and during daily activity using the WHOOP device. (2) …

heart failure
Accepts healthy volunteers
acute heart failure
  • 02 Dec, 2021
  • 1 location
Detection and Inflammatory Characterization of Deep Infection After Surgery for Locally Advanced Rectal Cancer With Microdialysis Catheters

The intention of the study is to explore metabolic and inflammatory parameters in the pelvis after abdominoperineal resection for locally advanced rectal cancer in patients that have received radiation therapy before surgery.

  • 30 Apr, 2022
  • 1 location
Clinical Value of Minimal Residual Disease Detection Based on Human Papillomavirus Circulating Tumor DNA (HPV ctDNA) in Cervical Cancer

In this study, a large-scale cohort of cervical cancer patients was established in multiple centers. Minimal residual disease(MRD) was assessed by ddPCR detection of HPV E7 gene ctDNA to assess tumor burden and predict the risk of disease recurrence, so as to provide new biomarkers for precise treatment of cervical …

  • 20 Oct, 2022
  • 1 location
DETECT: Target Volume for Rectal Endoluminal Radiation Boosting (DETECT)

The aim of the study is to provide prospective data regarding microscopic tumor spread in all directions from the macroscopic tumor in pathology specimens, as seen by eye, and on imaging to define the target volume for endoluminal radiation boosting in rectal cancer patients.

digital rectal examination
transrectal ultrasound
  • 07 Oct, 2022
  • 3 locations