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Found 734 clinical trials
TYRX™ Pocket Health Study

Medtronic, Inc. is sponsoring the TYRX™ Pocket Health Study to evaluate the histological and morphometric parameters of the device capsule in participants who underwent a cardiovascular implantable electronic device (CIED) procedure with a TYRX™ Absorbable Antibacterial Envelope and are returning for a CIED replacement procedure.

  • 21 Jul, 2022
  • 5 locations
Characterization of Retinal Disease Progression in Eyes With Non Proliferative Diabetic Retinopathy in Diabetes Type 2 Using Non-invasive Procedures (CHART) (CHART)

To identify biomarkers, obtained using non-invasive procedures, that can predict disease progression and progression to sight-threatening stages of the disease and to characterize the retinal changes that occur in Non Proliferative Diabetic Retinopathy (NPDR).

  • 23 Jul, 2022
  • 1 location
Circulating Biomarkers in Patients With Anal Cancer Treated With Induction Chemotherapy

To investigate the prognostic and predictive value of plasma HPV (pHPV) prior, during and after induction chemotherapy (ICT) in locally advanced squamous cell carcinoma of the anus (SCCA) or synchronous metastatic SCCA patients treated with ICT prior to definitive (chemo)radiotherapy ((C)RT) according to multidisciplinary team (MDT) conferences based decisions. Further …

  • 23 Mar, 2022
  • 1 location
Study on Gene Evolution and Anti-VEGF Treatment Response of Different Subtypes of Glioma Based on ctDNA

Little is known about the evolution of genetic and epigenetic changes that occur in the progression of glioma. We inferred the evolution trajectories of matched pairs of primary tumors and progression tumor in situ fluid (TISF) based on deep whole-genome-sequencing data (ctDNA). A monocentric, Gene grouping controlled trial design was …

  • 14 Sep, 2022
  • 1 location
Pacing to Maintain Physiologic Ventricular Activation

Right ventricular pacing causes ventricular dyssynchrony and may be associated with impaired outcome. In the last decade, several approaches for more physiological pacing became available and were implemented in the latest guidelines. However, compared to conventional device implantation, cardiac resynchronization, His bundle pacing and left bundle area pacing remain demanding …

cardiac resynchronization therapy
  • 16 Dec, 2021
  • 1 location
Olfactory Change After Chemo-radiotherapy for Nasopharyngeal Carcinoma

This is an observational cohort study aimed to explore the changes of olfactory function at multiple time points from baseline to 1 year after radiotherapy among the local advanced nasopharyngeal carcinoma patients.

nasopharyngeal carcinoma
chemotherapy regimen
induction chemotherapy
  • 22 Mar, 2022
  • 1 location
Whole-Heart Myocardial Blood Flow Quantification Using MRI

This study hopes to provide significant technical improvement in a Myocardial Blood Flow (MBF) cardiac magnetic resonance (CMR) quantification technique to address challenges and technical limitations for MBF CMR. By developing and validating novel techniques to improve first-pass perfusion (FPP) cardiac MR, we propose to increase diagnostic accuracy by minimizing …

myocardial perfusion imaging
arterial disease
perfusion imaging
coronary disease
  • 25 Feb, 2022
  • 1 location
Detection of Peritoneal Metastasis of Gastric Cancer by Liquid Biopsy in Peripheral Blood: A Prospective Study

This study is a prospective, multi-omics, observational study aimed at detecting peritoneal metastasis of gastric cancer by combined assays for methylation of cell-free DNA (cfDNA) and other blood-based biomarkers. The study will enroll 384 participants with gastric cancer.

primary cancer
  • 12 May, 2022
MRI-guided Lateral Lymph Node Dissection in Rectal Cancer

To investigate the oncological outcome of lateral lymph node dissection in low rectal cancer based on MRI

  • 07 May, 2021
  • 1 location
Wearable Remote Monitoring of Heart Rate and Respiratory Rate for Heart Failure

The primary objective of this study is to study in heart failure (HF) patients to better assess HF disease state, which can aid in management and improve outcomes. Primary aims of the study include: (1) Measure HR and RR at rest and during daily activity using the WHOOP device. (2) …

heart failure
acute heart failure
Accepts healthy volunteers
  • 02 Dec, 2021
  • 1 location