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Found 583 clinical trials
Phase 2 Study of OBP-301 (Telomelysin ) in Combination With Pembrolizumab and SBRT in Patients With HNSCC With Inoperable Recurrent or Progressive Disease

The purpose of this study is to test the effects, of the research study drug Telomelysin (OBP-301) in combination with pembrolizumab in subjects with inoperable, recurrent, or progressive squamous cell carcinoma of the head and neck. Telomelysin is an investigational treatment, while pembrolizumab and SBRT are approved standard treatments. The …

  • 0 views
  • 12 May, 2021
  • 1 location
Laparoscopic Robot-assisted Pelvic Exenteration for Pelvic Primary and Recurrent Cancers

The Radium Hospital Oslo University Hospital Estimated date of first patient enrolled: 3rd quarter 2021 Anticipated recruitment period: 4 years Estimated date of last patient completed: 4th quarter 2025 Locally advanced pelvic cancer that requires total pelvic exenteration Expected study-specific follow-up period per patient: 5 years according to standard follow-up …

  • 0 views
  • 18 Jan, 2022
Preoperative CRT With Capecitabine Temozolomide in Patients With LARC

This is a prospective biomarker-stratified, randomised phase II study of preoperative CRT with temozolomide plus capecitabine in patients with locally advanced rectal cancer. The primary endpoint is pathologic complete response rates defined as total regression of the primary tumor. For each cohort of MGMT hypermethylated versus MGMT unmethylated, patients will …

  • 26 views
  • 27 Jan, 2021
  • 1 location
Chemoradiotherapy in Esophageal or Esophagogastric Junction Cancer

Definitive chemoradiotherapy is the standard of care in unresectable esophageal or esophagogastric cancer. A multidisciplinary approach, including chemotherapy and radiotherapy, is important for

  • 0 views
  • 06 Apr, 2021
  • 1 location
PREACT Study: Locally Advanced Gastric Cancer Chemoradiotherapy vs. Chemotherapy Followed by D2 Surgery and Adjuvant Chemotherapy

lower esophageal adenocarcinomas, no pCR events were reported in this trial. The intervention arm in PREACT consists of pre-operative chemotherapy, pre-operative radiochemotherapy, surgery and post

curative surgery
gimeracil
oxaliplatin
tegafur-gimeracil-oteracil potassium
cancer chemotherapy
  • 22 views
  • 25 Jan, 2021
  • 1 location
Tri-weekly Cisplatin Based Chemoradiation in Locally Advanced Cervical Cancer

Current standard treatment for locally advanced cervical cancer is cisplatin-based concurrent chemoradiation (CRT). Although recently reported meta-analysis studies also demonstrated improved

brachytherapy
cancer
adenosquamous carcinoma
chemoradiotherapy
squamous cell carcinoma
  • 133 views
  • 22 Jan, 2021
  • 6 locations
Study Compare Adjuvant Chemotherapy Chemoradiotherapy and Surgery Alone for pN1-2(pT1b-3N1-2M0) Esophageal Carcinoma

A multi-center prospective randomized controlled study was conducted to compare the effects of adjuvant chemotherapy, chemoradiotherapy and surgery alone for the patients with esophageal cancer

esophageal carcinoma
squamous cell carcinoma
carcinoma
cancer
esophageal cancer
  • 0 views
  • 20 Nov, 2021
  • 1 location
Adjuvant Chemotherapy in Patients With Clinical Stage III Rectal Cancer Undergoing Neoadjuvant Chemoradiotherapy

The purpose of this study is to evaluate the efficacy of adjuvant chemotherapy in patients with clinical stage III rectal cancer who received neoadjuvant chemoradiotherapy on the basis of

rectal carcinoma
oxaliplatin
fluorouracil
carcinoma
cancer
  • 3 views
  • 22 Jan, 2021
Durvalumab(MEDI4736) After chemoRadioTherapy(DART) for NSCLC-a Translational and Biomarker Study

The main aim is to identify and describe biomarkers in different sample types related to chemoradiation followed by durvalumab treatment for stage III PD-L1 negative and positive non-small cell

medi4736
serum bilirubin level
platelet count
bilateral oophorectomy
neutrophil count
  • 0 views
  • 08 Dec, 2021
  • 10 locations
Radiation Therapy or Chemoradiation Interstitial Brachytherapy in Combination With Hyperthermia in Advanced Cervical Cancer

The combination of radiation therapy or chemoradiation with Interstitial brachytherapy for advanced cervical cancer (pN+, FIGO-Stage II B - IV A is standard of therapy. The radio- and

brachytherapy
cancer
chemoradiotherapy
carcinoma
cervical carcinoma
  • 11 views
  • 21 Jan, 2021
  • 1 location