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Found 38 clinical trials
Biomarker Driven Intensified ChemoImmunotherapy With Early CNS Prophylaxis (Bio-CHIC)

This study is testing whether stratification of the patients according to biological risk factors for different treatment groups will improve the outcome of patients with clinically high diffuse large B-cell lymphoma (DLBCL).

t-cell lymphoma
follicular lymphoma
b-cell lymphoma
da-epoch
large cell lymphoma
  • 42 views
  • 31 Jan, 2022
  • 16 locations
Rituximab and Lenalidomide vs Rituximab Alone as Maintenance After R-chemoterapy for Relapsed/Refractory FL Patients (FIL_RENOIR12)

A randomized phase III multicenter trial assessing efficacy and toxicity of a combination of Rituximab and Lenalidomide (R2) vs Rituximab alone as maintenance after chemoimmunotherapy with

neutrophil count
tumor burden
rituximab
bendamustine
lenalidomide
  • 55 views
  • 23 Mar, 2022
  • 28 locations
Efficacy of Tedopi Plus Docetaxel or Tedopi Plus Nivolumab as Second-line Therapy in Metastatic Non-small-cell Lung Cancer Progressing After First-line Chemo-immunotherapy (Combi-TED) (COMBI-TED)

This is a phase II, non-comparative, randomized study assessing combination of Tedopi with docetaxel or with nivolumab in NSCLC patients failing after first- line chemoimmunotherapy. In this non

  • 0 views
  • 11 Mar, 2022
  • 5 locations
Staggered, Chemo-Immunotherapy With Durvalumab, MEDI4736 Pemetrexed & Carboplatin (PC) for Metastatic Non-Squamous NSCLC (STAGGER)

This is a Phase II, open label, randomized study of durvalumab in combination with pemetrexed and carboplatin in eligible adult patients with locally advanced or metastatic non-small cell lung cancer. The study will focus on the efficacy of two alternative staggered dosing regimens.

gilbert's syndrome
carboplatin
measurable disease
pemetrexed
durvalumab
  • 0 views
  • 11 Mar, 2022
  • 1 location
Phase 2 Study of Plamotamab Combined With Tafasitamab Plus Lenalidomide Versus Tafasitamab Plus Lenalidomide in R/R DLBCL

The purpose of this study is to investigate the safety and effectiveness of plamotamab when it is given with tafasitamab and lenalidomide in relapsed or refractory DLBCL.

  • 0 views
  • 11 May, 2022
  • 1 location
Study of Acalabrutinib (ACP-196) in Combination With Venetoclax (ABT-199), With and Without Obinutuzumab (GA101) Versus Chemoimmunotherapy for Previously Untreated CLL

compared to chemoimmunotherapy in subjects with previously untreated CLL.

abt-199
obinutuzumab
acalabrutinib
fludarabine
rituximab
  • 388 views
  • 20 Apr, 2022
  • 11 locations
Study in Subjects With Relapsed/Refractory Follicular Lymphoma

designed to evaluate the efficacy and safety of tazemetostat in combination with R2 in subjects with R/R FL, who have completed at least 1 prior systemic chemotherapy, immunotherapy, or chemoimmunotherapy

  • 2 views
  • 28 Feb, 2022
  • 53 locations
A Study of Venetoclax in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

receive chemoimmunotherapy (CIT) irrespective of 17p status (Cohort 2).

chronic lymphocytic leukemia
measurable disease
lymphadenopathy
cancer
chronic lymphocytic leukemia refractory
  • 229 views
  • 10 May, 2022
  • 30 locations
Chemoimmunotherapy and Allogeneic Stem Cell Transplant for NK T-cell Leukemia/Lymphoma

Patients are in 2 cohorts: Cohort 1: dexamethasone, methotrexate, ifosfamide, pegaspargase, and etoposide (modified SMILE) chemotherapy regimen alone and pembrolizumab in children, adolescents, and young adults with advanced stage NK lymphoma and leukemia Cohort 2: combining pralatrexate (PRX) (Cycles 1, 2, 4, 6) and brentuximab vedotin (BV) (Cycles 3, 5) …

ejection fraction
peripheral t-cell lymphoma
adult t-cell leukemia
extranodal nk/t-cell lymphoma
extranodal nk/t-cell lymphoma, nasal type
  • 39 views
  • 28 Feb, 2022
  • 2 locations
Perioperative Chemoimmunotherapy With/Without Preoperative Chemoradiation for Locally Advanced Gastric Cancer

NeoRacing is a randomized phase II trial carried out at Fudan University Shanghai Cancer Center (FUSCC) in China. The study can be divided into the screening stage, treatment stage and follow-up stage. The enrolled patients will receive perioperative SOX chemotherapy, PD-1 antibody (sintilimab) and radical surgery, with or without preoperative …

cancer chemotherapy
tegafur
lymphadenectomy
treatment regimen
cancer
  • 0 views
  • 25 Dec, 2021
  • 1 location