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Found 9 clinical trials
Safety of SP-420 in the Treatment of Transfusional Iron Overload

may be better tolerated and safer than commercially available iron chelators. Iron chelation therapy (ICT) has been shown to improve outcomes in iron overload, but adherence is poor due to problems

serum ferritin level
oophorectomy
packed red blood cells
chelation therapy
hysterectomy
  • 0 views
  • 07 Oct, 2022
  • 1 location
A Phase 3, Double-blind, Randomized Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK Inhibitor Therapy and Who Require Red Blood Cell Transfusions (INDEPENDENCE)

The purpose of this Phase 3 study is to evaluate the efficacy and safety of Luspatercept compared with placebo in subjects with myeloproliferative neoplasm (MPN)-associated Myelofibrosis (MF) and anemia on concomitant Janus kinase 2 (JAK2) inhibitor therapy and who require red blood cell count (RBC) transfusions. The study is divided …

cancer
anemia
vasectomy
bilateral oophorectomy
  • 36 views
  • 28 Oct, 2022
  • 163 locations
Trial to Assess Chelation Therapy in Critical Limb Ischemia (TACT3a)

TACT3a is a double blind, placebo-controlled, randomized trial to test a novel therapy, edetate disodium-based chelation of environmentally acquired toxic metals, to reduce cardiovascular events including amputation in high-risk diabetic patients.

fasting blood glucose
gangrene
diabetes
limb ischemia
healing ulceration
  • 22 views
  • 09 Feb, 2022
  • 1 location
A Phase 1/2a Exploratory Clinical Trial to Evaluate the Safety of Oral Deferiprone (14 Days) Including Its Effect on Decreasing the Content of Iron in Subjects With Aneurysmal Subarachnoid Hemorrhage (aSAH) sIRB

temporal lobe (hippocampus, impairing patients' cognition. It is estimated that 50% of survivors have cognitive deficits. Most of the survivors of SAH could not return to work. Iron chelation

stroke
cognitive assessment
anesthesia
alzheimer's disease
cognitive disorder
  • 0 views
  • 27 Oct, 2022
  • 1 location
Study of Safety & PK of Luspatercept (ACE-536) in Pediatric Participants Who Require Regular RBC Transfusions Due to Beta (β)-Thalassemia.

This is a Phase 2a study to evaluate the safety and pharmacokinetics (PK) of luspatercept in pediatric participants who require regular red blood cell transfusions due to β-thalassemia. The study will be conducted in 2 parts: Part A will be in adolescent participants aged 12 to <18 years with two …

luspatercept
hemoglobin e
progesterone
blood transfusion
hysterectomy
  • 6 views
  • 04 Jun, 2022
  • 1 location
Observational Study for Patients With Hemoglobinopathies and Rare Inherited Anemia and Covid 19

The COVID-19 pandemic is causing many deaths around the world, putting a strain on health services. Patients with pre-existing chronic conditions are most affected by the SARS-COV2 infection. Infectious complications are a common cause of mortality and one of the main causes of morbidity in all these diseases. The main …

  • 0 views
  • 17 May, 2022
  • 2 locations
The Natural History of Acquired and Inherited Bone Marrow Failure Syndromes.

Background Bone marrow failure diseases are rare. Much is known about the diseases at the time of diagnosis, but long-term data about the effects of the diseases and treatments are lacking. Researchers want to better understand long-term outcomes in people with these diseases. Objective To follow people diagnosed with acquired …

  • 0 views
  • 21 Oct, 2022
  • 1 location
Natural History of Wilson Disease

The purpose of the registry/repository is to provide a mechanism to store data and specimens to support the conduct of future research about Wilson disease (WD). The overall aim is to determine the optimal testing for diagnosis and parameters for monitoring treatment of WD that will aid product utilization and …

  • 177 views
  • 04 Oct, 2022
  • 6 locations
Efficacy and Safety of Luspatercept: A Study by Fondazione Italiana Sindromi Mielodisplastiche (FISiM-Luspa)

Myelodysplastic syndromes (MDS) are a group of malignancies characterized by reduced differentiation and increased apoptosis of hematopoietic progenitor cells, leading to ineffective hematopoiesis. Treatment of MDS varies according to prognosis. Patients with low IPSS-R risk have a low probability of progression to acute myeloid leukemia (AML) and the treatment is …

growth factor
myeloid leukemia
anemia
leukemia
cytopenia
  • 0 views
  • 07 Oct, 2022
  • 1 location