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Found 11 clinical trials
Safety of SP-420 in the Treatment of Transfusional Iron Overload

may be better tolerated and safer than commercially available iron chelators. Iron chelation therapy (ICT) has been shown to improve outcomes in iron overload, but adherence is poor due to problems

chelators
chelation therapy
packed red blood cells
oophorectomy
serum ferritin level
  • 0 views
  • 03 Jul, 2021
  • 1 location
Iron Balance Study of Deferasirox Deferoxamine and the Combination of Both

dysfunctions. Lifelong iron chelation therapy is needed to maintain iron balance but its effectiveness varies greatly. Like that of deferoxamine (Desferal, DFO) the mainstay of chelation therapy

chelation therapy
iron
iron overload
blood transfusion
diabetes
  • 28 views
  • 07 Nov, 2020
  • 1 location
An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK2 Inhibitor Therapy and Who Require Red Blood Cell Transfusions

The purpose of this Phase 3 study is to evaluate the efficacy and safety of Luspatercept compared with placebo in subjects with myeloproliferative neoplasm (MPN)-associated Myelofibrosis (MF) and anemia on concomitant Janus kinase 2 (JAK2) inhibitor therapy and who require red blood cell count (RBC) transfusions. The study is divided …

vasectomy
anemia
cancer
bilateral oophorectomy
  • 0 views
  • 02 Aug, 2021
  • 158 locations
Study of Safety & PK of Luspatercept (ACE-536) in Pediatric Participants Who Require Regular RBC Transfusions Due to Beta ( )-Thalassemia.

This is a Phase 2a study to evaluate the safety and pharmacokinetics (PK) of luspatercept in pediatric participants who require regular red blood cell transfusions due to -thalassemia. The study will be conducted in 2 parts: Part A will be in adolescent participants aged 12 to <18 years with two …

ace-536
hemoglobin e
progesterone
blood transfusion
luspatercept
  • 4 views
  • 18 Jun, 2021
  • 8 locations
Trial to Assess Chelation Therapy in Critical Limb Ischemia

TACT3a is a double blind, placebo-controlled, randomized trial to test a novel therapy, edetate disodium-based chelation of environmentally acquired toxic metals, to reduce cardiovascular events including amputation in high-risk diabetic patients.

angiography
healing ulceration
hemoglobin a1c
insulin
diabetes
  • 0 views
  • 25 Jan, 2021
  • 1 location
Environmental Exposure to Lead and Its Health Effects on Patients With Maintenance Hemodialysis

assigned to the study and control groups. For 3-6 months, the 50 patients in the study group will receive lead-chelation therapy with calcium disodium EDTA weekly until the BLB falls below BLL

calcium
maintenance hemodialysis
  • 17 views
  • 07 Nov, 2020
  • 1 location
Pilot Study to Assess the Safety PK and Iron Chelating Activity of DST-0509 (Deferasirox) in Thalassemia Patients Refractory to Chelation

compared to Jadenu and Exjade in transfusion-dependent thalassemia patients with transfusional iron overload, requiring iron chelation therapy and demonstrating an inadequate response to Jadenu or Exjade

chelation therapy
deferasirox tablets
iron
iron overload
blood transfusion
  • 40 views
  • 22 Jun, 2021
  • 6 locations
Deferiprone for Ruptured Brain Aneurysm

temporal lobe (hippocampus, impairing patients' cognition. It is estimated that 50% of survivors have cognitive deficits. Most of the survivors of SAH could not return to work. Iron chelation

dementia
stroke
anesthesia
cognitive assessment
alzheimer's disease
  • 0 views
  • 18 Apr, 2021
  • 1 location
Factors Promoting Increased Rate and Success of Pregnancy in the Thalassemia Population in Toronto

Treatment of patients with beta thalassemia in North America has altered dramatically during the past 40 years, with improvements in transfusion therapy and introduction of iron chelation

beta thalassemia
pregnancy complication
chelation therapy
iron
blood transfusion
  • 123 views
  • 07 Nov, 2020
  • 1 location
Natural History of Wilson Disease

The purpose of the registry/repository is to provide a mechanism to store data and specimens to support the conduct of future research about Wilson disease (WD). The overall aim is to determine the optimal testing for diagnosis and parameters for monitoring treatment of WD that will aid product utilization and …

  • 175 views
  • 25 Jul, 2021
  • 6 locations