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Found 78 clinical trials
A Phase 2 Randomized Study of Osimertinib Versus Osimertinib Plus Chemotherapy for Patients With Metastatic EGFR-Mutant Lung Cancers That Have Detectable EGFR-Mutant cfDNA in Plasma After Initiation of Osimertinib

This study will compare the effectiveness of osimertinib alone with the combination of osimertinib and chemotherapy (carboplatin and pemetrexed) in people with metastatic lung cancer that has a change (mutation) in the gene EGFR. Osimertinib alone is the usual treatment for metastatic EGFR-mutant lung cancer. Researchers think adding chemotherapy to …

neutrophil count
metastasis
carboplatin
pemetrexed
EGFR
  • 37 views
  • 23 Oct, 2022
  • 12 locations
Modified Immune Cells (TAG72-CAR T Cells) for the Treatment of Patients With Platinum Resistant Epithelial Ovarian Cancer

This phase I trial tests the safety, side effects, and best dose of TAG72-chimeric antigen receptor (CAR) T cells in treating patients with epithelial ovarian cancer that remains despite treatment with platinum therapy (platinum resistant). T cells are infection fighting blood cells that can kill tumor cells. The T cells …

  • 0 views
  • 04 Oct, 2022
  • 1 location
RCT Study to Validate niPGT-A Clinical Benefit. (niPGT-A_RCT)

media reportedly contains traces of embryonic cell-free DNA (cfDNA) that can represent the genetic load of the embryo. On the basis of that, the hypothesis of this study is that embryo

embryo culture
discomfort
in vitro fertilization
intracytoplasmic sperm injection
  • 987 views
  • 26 Feb, 2022
  • 4 locations
IMMUNOtherapy and Stereotactic ABlative Radiotherapy (IMMUNOSABR) a Phase II Study (IMMUNOSABR2)

This will be a phase II trial testing if the combination of stereotactic ablative body radiotherapy (SABR) and L19-IL2 improve the progression-free survival in patients with limited metastatic non-small cell lung cancer (NSCLC). The trial consists of one cohort with two arms; C-arm and an E-arm. Patients with oligometastatic disease …

neutrophil count
metastasis
stereotactic body radiation therapy
renal function test
liver metastasis
  • 2 views
  • 03 Mar, 2022
  • 10 locations
(CompassHER2-pCR): Preoperative THP and Postoperative HP in Patients Who Achieve a Pathologic Complete Response

This trial studies how well paclitaxel, trastuzumab, and pertuzumab work in eliminating further chemotherapy after surgery in patients with HER2-positive stage II-IIIa breast cancer who have no cancer remaining at surgery (either in the breast or underarm lymph nodes) after pre-operative chemotherapy and HER2-targeted therapy. Drugs used in chemotherapy, such …

hcv viral load
neutrophil count
carcinoma in situ
paclitaxel
trastuzumab
  • 97 views
  • 17 Oct, 2022
  • 643 locations
Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial (ALCHEMIST)

This ALCHEMIST trial studies genetic testing in screening patients with stage IB-IIIA non-small cell lung cancer that has been or will be removed by surgery. Studying the genes in a patient's tumor cells may help doctors select the best treatment for patients that have certain genetic changes.

nivolumab
crizotinib
metastasis
paclitaxel
pemetrexed
  • 1154 views
  • 21 Oct, 2022
  • 1027 locations
Study of Nivolumab-Ipilimumab and cfDNA in Lung Cancer (ATLAS)

The purpose of this research study is to look at how effective two drugs, nivolumab and ipilimumab, are for people with non-small lung cancer that has metastasized (has spread to other parts of the body) and to see what effects these drugs have on these tumors.

lung carcinoma
small lung
platinum-based chemotherapy
nivolumab
carboplatin
  • 0 views
  • 23 May, 2022
  • 1 location
Evaluation of cfDNA as a Marker of Response in Rectal Cancer

biomarker of response, in liquid biopsy, for rectal cancer. The concentration of baseline plasma cell-free DNA (cfDNA) appears significantly higher in responders compared to non-responders. The

BRAF
KRAS
adenocarcinoma of rectum
chemoradiotherapy
adenocarcinoma
  • 0 views
  • 02 Mar, 2022
  • 1 location
Molecular Monitoring of cfDNA by ddPCR in Non-small Cell Lung Cancer Treated by Immunotherapy.

Non-small cell lung cancer (NSCLC) is a major public health problem. New treatments as immunotherapy can improve prognosis of patients with NCLC tumors. Nevertheless, no robust biomarker is actually available. The hypothesis of the trial is to realize a longitudinal molecular monitoring of NSCLC patients treated by immunotherapy using a …

lung carcinoma
progressive disease
  • 0 views
  • 17 Jun, 2022
  • 6 locations
Whole-body DW-MRI and cfDNA Analysis for the Surveillance of Melanoma Patients at High Risk for Recurrence.

. No standards have been established for the surveillance of patients at high risk for recurrence. Whole-body diffusion-weighted magnetic resonance imaging and cfDNA analysis of blood are innovative

advanced melanoma
systemic therapy
metastatic melanoma
  • 8 views
  • 26 Jan, 2021
  • 3 locations