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Found 46 clinical trials
Gene Therapy Study for Children With CLN5 Batten Disease (CLN5-200)

This is a prospective, non-randomized, open-label study of a single dose administration of gene therapy in children who are 3 to 8 years old with Neuronal Ceroid Lipofuscinosis (Batten) Subtype

  • 0 views
  • 10 Mar, 2022
  • 1 location
An Open-label Safety, Pharmacokinetic, and Efficacy Study of the Combination of Trehalose and Miglustat for the Treatment of CLN3 Disease

g/kg administered once-weekly) and the MTD of oral miglustat (100 mg once daily [QD] to 200 mg 3 times daily [TID]) in subjects ≥ 17 years of age with CLN3 disease over a period of 104 weeks.

  • 0 views
  • 23 Mar, 2022
  • 1 location
Study for the Treatment for CLN7 Disease

This is a phase 1 open-label, single-administration of gene therapy agent AAV9/CLN7, administered intrathecally into the lumbar spinal cord region of pediatric patients with CLN7 Batten disease

  • 4 views
  • 24 May, 2021
  • 1 location
TeamBaby - Safe, Digitally Supported Communication in Obstetrics and Gynecology (TeamBaby)

- online training (observations, interviews, focus groups) incl. retrospective cohort study and pre-experimental study pre/post-test (interviews, analysis of hospital data); 2. effectiveness study with

Accepts healthy volunteers
  • 0 views
  • 23 Mar, 2022
  • 1 location
Scrub Typhus Antibiotic Resistance Trial (START)

) characterization of the therapeutic responses for doxycycline and azithromycin, incl. serial bacterial load measurements. To define clinical, bacterial, pathophysiological and pharmacological factors

  • 10 views
  • 13 Apr, 2022
  • 1 location
CytoSorb SAH Trial

severe disease incl. respiratory failure, septic shock, and or multiple organ dysfunction/failure. Until now, effective IL-6 removal in patients suffering from aSAH has not been possible in human

  • 0 views
  • 05 Mar, 2022
  • 1 location
Comparative Study in Patients With Refractory Chronic Lower Limb Neuropathic Pain and/or Back Neuropathic Pain.

the separate standalone stimulation types, compare the different cortical pathways involved in both techniques, by functional imaging, incl. MRI, analyze energy consumption by optimizing neural

  • 0 views
  • 06 Dec, 2021
  • 1 location
Effects of Peripherally Acting µ-opioid Receptor Antagonists on Acute Pancreatitis

This study will investigate the effect of peripheral acting opioid antagonist (PAMORA) on the disease course of patients with acute inflammation of the pancreas (acute pancreatitis). The study will be conducted by treating hospitalized patients with acute pancreatitis with a PAMORA (methylnaltrexone).

  • 0 views
  • 13 Dec, 2021
  • 4 locations
Trial With or Without Infusion of SARS-CoV-2 Antibody Containing Plasma in High-Risk Patients With COVID-19 (RECOVER)

The study RECOVER is a randomized, open-label, multicenter phase II trial, designed to assess the clinical outcome of SARS-CoV-2 disease in high-risk patients (group 1 to group 4) following treatment with anti-SARS-CoV-2 convalescent/vaccine-boosted plasma or standard of care.

  • 0 views
  • 25 Mar, 2022
  • 1 location
Spondyloarthritis: Inducing Drug-free Remission by Early TNF-alpha Blockade (SPARTACUS)

The SPARTACUS study will explore the therapeutic efficacy of 2 different treatment strategies for patients suffering from peripheral Spondyloarthritis (pSpA), classified according to the "Assessment in SpondyloArthritis international Society" (ASAS) classification criteria; it will be set up as a 48-week, prospective, randomized, active-comparator controlled, double-blind, double-dummy, clinical trial with a …

  • 0 views
  • 25 Mar, 2022
  • 2 locations