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Found 14 clinical trials
Roll-over Study to Allow Access to Certinib (LDK378) for Patients Who Are on Ceritinib Treatment in a Novartis-sponsored Study

The rollover study will provide ceritinib to patients who are currently receiving treatment with ceritinib within a Novartis-sponsored study and in the opinion of the investigator, would benefit

  • 0 views
  • 24 Dec, 2020
  • 3 locations
Ceritinib + Trametinib in Patients With Advanced ALK-Positive Non-Small Cell Lung Cancer (NSCLC)

This is a phase I/II study of ceritinib and trametinib in Stage IIIB or IV anaplastic lymphoma kinase (ALK) rearranged non-small cell lung cancer (NSCLC). The Phase I portion will investigate

proto-oncogene tyrosine-protein kinase ros
metastasis
brigatinib
secondary malignant neoplasm of liver
lipase
  • 24 views
  • 13 Jul, 2020
  • 3 locations
Lorlatinib After Failure of First-line Second-generation ALK Kinase Inhibitor in Patients With Advanced ALK-positive Non-small Cell Lung Cancer

, ceritinib and brigatinib are second-generation ITK-ALK. They have been shown to be effective in the first line of treatment in randomized trials. Alectinib has shown superiority to crizotinib as the first

  • 0 views
  • 30 Sep, 2020
  • 30 locations
Trial of Brigatinib After Treatment With Next-Generation ALK Inhibitors

The purpose of this study is to evaluate the safety and effectiveness of this investigational drug, brigatinib (AP261136) in patients with advanced non-small cell lung cancer Non-small cell lung cancer (NSCLC) who have had first-line treatment for their cancer and it still got worse, even after, or while taking drugs …

metastasis
brigatinib
serum bilirubin level
stage iv non-small cell lung cancer
secondary malignant neoplasm of liver
  • 0 views
  • 03 Feb, 2020
  • 4 locations
Study of Lorlatinib in ROS1 Rearranged NSCLC

This is a phase II, multi-center, single arm study of lorlarinib as a single agent in patients with ROS1-rearranged advanced NSCLC.

platinum doublet
proto-oncogene tyrosine-protein kinase ros
ROS1
recurrent non-small cell lung cancer
kidney function test
  • 0 views
  • 17 Sep, 2020
  • 1 location
Study of Lorlatinib In Participants With Anaplastic Lymphoma Kinase (ALK) -Positive NSCLC

ceritinib as the first ALK tyrosine kinase inhibitor (TKI)therapy.

administration intravenous
cancer treatment
lymphoma
ceritinib
cancer
  • 0 views
  • 18 Jan, 2021
  • 27 locations
Targeted Treatment for ALK Positive Patients Who Have Previously Been Treated for Non-squamous Non-small Cell Lung Cancer

-squamous non-small cell lung cancer. Lorlatinib, ceritinib, alectinib, brigatinib, ensartinib, and crizotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth

metastasis
brigatinib
tubal ligation
stage iv non-small cell lung cancer
kinase inhibitor
  • 143 views
  • 15 Jan, 2021
  • 387 locations
Ceritinib Plus Docetaxel in ALK-Negative EGFR WT Advanced NSCLC

The main purpose of this study is to find out what effects (good and bad) ceritinib (Zykadia) used in combination with docetaxel (Taxotere) will have on participants and their cancer. The

brain metastases
metastasis
EGFR
taxotere
stage iv non-small cell lung cancer
  • 8 views
  • 13 Jan, 2021
  • 2 locations
Study of Trametinib + Ceritinib in Patients With Unresectable Melanoma

The main purpose of this study is to determine the risks and benefits of ceritinib (ZYKADIA) given in combination with trametinib (MEKINIST) in patients who have progressed on prior melanoma

unresectable melanoma
mekinist
trametinib
solid tumour
pd-l1
  • 1 views
  • 04 Nov, 2020
  • 1 location
Ceritinib and Everolimus in Treating Patients With Locally Advanced or Metastatic Solid Tumors or Stage IIIB-IV Non-small Cell Lung Cancer

This phase I trial studies the side effects and best dose of ceritinib and everolimus in treating patients with solid tumors that have spread from where they started to nearby tissue or lymph

tumor cells
metastasis
systemic therapy
cancer
liver metastasis
  • 37 views
  • 25 Feb, 2020
  • 1 location