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Found 19 clinical trials
Can the Relative Fecal Abundance of BLSE and the Digestive Microbiota be Predictive of the Risk of Infection in a Carrier Patient?

Resistance Surveillance Network evaluated, among clinical strains, the rate of resistance to 3rd generation cephalosporins (C3G) at 9.5% for E. coli and 28% for K. pneumoniae. Numerous studies have shown

  • 0 views
  • 03 May, 2021
  • 4 locations
Identification of Gut Microbiome Biomarkers Associated to Acquisition of Enterobacteriae Highly Resistant to Third Generation Cephalosporines Following Ceftriaxone Treatment. (ARCMI)

Patients receiving Ceftriaxone 1 gram or 2 grams per day during their presence in emergency unit of hospital whatever their medical condition, will be included. Rectal swabs will be collected at inclusion and at days 5 and 30 to perform analysis. Analysis will be performed to characterize gut microbiome in …

  • 0 views
  • 07 Feb, 2022
  • 1 location
Non-inferiority Trial Comparing Cloxacillin vs Cefazolin in Methicillin-susceptible Staphylococcus Aureus Bacteremia (CLOCEBA)

"Methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia remains a major cause of community- or hospital-acquired bloodstream infections with an overall mortality estimated around 25%. Anti-staphylococcal penicillins (APs) such as oxacillin or cloxacillin are recommended as first-line agents. With the exception of first-generation cephalosporin (1GC) such as cefazolin, no alternative has yet proven …

  • 9 views
  • 27 Feb, 2022
  • 1 location
Switch to Oral Antibiotics in Gram-negative Bacteremia (SOAB)

. The bloodstream isolate must be susceptible to amoxicillin, amoxicillin-clavulanate, fluoroquinolones, oral cephalosporins and/or trimethoprim-sulfamethoxazole and the subject must be able to take

  • 77 views
  • 18 Apr, 2022
  • 7 locations
The Expected Advantage of Administering Prophylactic Antibiotics Using Target- Concentration Controlled Infusion

are selected depending on the type of surgery, and first- or second-generation cephalosporins have been mainly used. Cefoxitin, a second-generation cephalosporin with anaerobic activity, has been used

  • 0 views
  • 02 May, 2022
  • 1 location
Selective Decontamination of the Digestive Tract in Intensive Care Unit Patients (SuDDICU)

Introduction- Hospital acquired infections (HAI) are a major cause of morbidity and mortality and increase health care costs. Critically ill patients are particularly susceptible to these infections and have an even higher mortality. One intervention that has gained much interest in the medical literature for reducing infection rates and deaths …

antibiotics
nosocomial infections
antibiotic therapy
critical illness
mechanical ventilation
  • 13 views
  • 01 May, 2022
  • 1 location
PipEracillin Tazobactam Versus mERoPENem for Treatment of Bloodstream Infections Caused by Cephalosporin-resistant Enterobacteriaceae (PETERPEN)

Data regarding optimal treatment for extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae blood-stream infection are lacking. Observational studies show conflicting results when comparing treatment with combination beta-lactam-beta-lactamase inhibitor and carbapenems. The investigators aim to evaluate the effect of definitive treatment with meropenem vs. piperacillin-tazobactam on the outcome of patients with bacteremia due …

carbapenem
piperacillin-tazobactam
lactam
beta-lactamase inhibitor
piperacillin
  • 23 views
  • 28 Oct, 2021
  • 2 locations
Temocillin vs Meropenem for the Targeted Treatment of Bacteraemia Resistant to Third Gen Cephalosporins

A Phase 3, Multicenter, Randomised, Controlled, Open-Label Study to demonstrate noninferiority of temocillin (unauthorized investigational medicinal product IMP in Spain, but authorized in Belgium and UK) vs a carbapenem antibiotic (meropenem) in adults with bacteraemia due to third-generation cephalosporin-resistant Enterobacteriaceae. The duration of treatment will be between 7 and 14 …

carbapenem
antibiotics
cephalosporins
ceftazidime
ceftriaxone
  • 0 views
  • 20 Oct, 2021
  • 32 locations
Adjunction of Daptomycin for the Treatment of Pneumococcal Meningitis (AddaMAP)

generation cephalosporins. Nevertheless, complications associated with meningitis are relatively frequent and severe. Recent animal studies have shown that another antibiotic, daptomycin, can reduce the

antibiotics
meningitis
  • 16 views
  • 01 Mar, 2022
  • 1 location
Target Attainment of Cefuroxim

other cephalosporins, time-dependent killing. The pharmacodynamic target can therefore be best described as the percentage of the dosing interval that the serum concentration remains above the minimum

  • 0 views
  • 27 Apr, 2022
  • 1 location