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Found 53 clinical trials
Featured trial
A Randomized Trial of Sirolimus (Rapamune) for Relapse Prevention in Patients with Severe Aplastic Anemia Responsive to Immunosuppressive Therapy

Background: People with severe aplastic anemia (SAA) do not make enough red and white blood cells, and/or platelets. Their body's immune system stops the bone marrow from making these cells. The treatment cyclosporine leads to better blood counts. But when this treatment is stopped, the disease may return in 1 …

anemia studies
myelodysplastic syndromes
anemia
aplastic anemia
myelodysplastic syndrome (mds)
  • 75 views
  • 22 Dec, 2020
  • 1 location
Featured trial
Eltrombopag Added to Standard Immunosuppression in Treatment-Naive Severe Aplastic Anemia

Background: Severe aplastic anemia is a rare and serious blood disorder. It happens when the immune system starts to attack the bone marrow cells. This causes the bone marrow to stop making red blood cells, platelets, and white blood cells. Standard treatment for this disease is horse-ATG and cyclosporine, which …

anemia studies
myelodysplastic syndromes
anemia
aplastic anemia
myelodysplastic syndrome (mds)
  • 172 views
  • 22 Dec, 2020
  • 1 location
NMF-CsA-Dupi Trial

The goal of this study is to investigate whether stratification of children with atopic dermatitis on the NMF biomarkers results in an improvement of effectiveness and efficiency in the use of systemic treatment (ciclosporin and dupilumab) in moderate-to-severe atopic dermatitis.

high potency
eczema
dupilumab
cyclosporine
topical corticosteroid
  • 0 views
  • 26 Aug, 2021
  • 1 location
Efficacy and Safety of CSA and Avatrombopag for the Treatment of SAA in the Elderly (SAA)

This is a multicenter, single-arm clinical study. The objective was to evaluate the efficacy and safety of CSA in combination with Avatrombopag in elderly patients with very/sever aplastic

  • 0 views
  • 10 Jul, 2022
  • 1 location
Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA)

SSA is a combination of 3 drugs (Cyclosporine [CsA], Eltrombopag [EPAG], and horse anti-thymocyte globulin [h-ATG]). Researchers want to see if starting people at a lower dose of CsA with EPAG before

antithymocyte globulin
immunosuppression
reticulocyte count
immunosuppressant
blood test
  • 12 views
  • 04 Oct, 2022
  • 1 location
The Safety and Efficacy Study of Avatrombopag Switch in TPO-RA Refractory AA

This study was a single-arm, multicenter, phase Π clinical study. Patients admitted to the enrollment unit center with a confirmed diagnosis of TDNSAA/VSAA/SAA, treated with IST (p/r-ATG+CSA) in

  • 0 views
  • 07 Oct, 2022
  • 1 location
Radiofrequency Perineural Injection Idiopathic Carpal Tunnel Syndrome

>VAS (visual analogue pain scale) BCTQ (Boston carpal tunnel Questionnaire) Degree of paresthesia tested by Reverse Phalen's test. CSA (cross sectional area)0 of the median

paresthesia
bupivacaine
Accepts healthy volunteers
tingling sensation
nerve conduction
  • 1 views
  • 06 Oct, 2021
  • 1 location
A Randomized Trial of Sirolimus (Rapamune(R)) for Relapse Prevention in Patients With Severe Aplastic Anemia Responsive to Immunosuppressive Therapy

Background People with severe aplastic anemia (SAA) do not make enough red and white blood cells, and/or platelets. Their body's immune system stops the bone marrow from making these cells. The treatment cyclosporine leads to better blood counts. But when this treatment is stopped, the disease may return in 1 …

sirolimus
reticulocyte count
white blood cells
aplastic anemia
immunosuppressant
  • 14 views
  • 24 Oct, 2022
  • 1 location
Validation of a Digital Twin Performing Strength Training

Background: Muscular strength training interventions have long been a cornerstone in the prevention, non-surgical management and rehabilitation of the entire spectrum of musculoskeletal injuries and diseases. The key goal of strength training, especially during rehabilitation, is to regain healthy musculoskeletal function. Yet, there remains a fundamental lack of understanding with …

Accepts healthy volunteers
  • 0 views
  • 04 Oct, 2022
  • 1 location
Vascular Occlusion for Optimizing Functional Improvement in Patients With Knee Osteoarthritis

Recent research in strength training physiology revealed that implementation of occlusion garments around the proximal aspect of the lower limbs in combination with low load strength training causes a reduced blood flow and thus providing a high metabolic stimulus, causing a training effect similar to high load training. This study …

  • 0 views
  • 18 Aug, 2021
  • 1 location