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Found 67 clinical trials
RESTORE-IT-Study of Rifalazil in Chlamydia Pneumoniae Seropositive Patients With a History of Atherosclerotic Disease

The objective of this study is to evaluate an antibiotic therapy called Rifalazil to determine its effect on hardening of the carotid arteries.

intermittent claudication
myocardial infarction
percutaneous coronary intervention
pneumonia
statin
  • 57 views
  • 07 Nov, 2020
  • 1 location
Angiotensin II in General Anesthesia

Hypotension in adult patients undergoing general anesthesia is common. This can lead to hypoperfusion of vital organs, organ damage, and states of increased metabolic duress. This may be worse in patients with underlying essential hypertension and worse in patients taking Angiotensin Converting Enzyme Inhibitors (ACE) and Angiotensin Receptor Blockers (ARBs). …

angiotensin ii receptor antagonist
angiotensin ii
antihypertensive drugs
systolic blood pressure
anesthesia
  • 0 views
  • 24 Jan, 2021
  • 1 location
Impact of Mild or Moderate Physical Activity and Progression of Subclinical Atherosclerosis

Subclinical atherosclerosis is identified in roughly 2/3rd of otherwise healthy young adults. How much physical activity is required to prevent progression of subclinical atherosclerosis? In the 85% of healthy younger Canadian men and women who do NOT perform the recommended 150 min/week of moderate- to vigorous-intensity physical activity (MVPA) as …

atherosclerosis
diabetes
body mass index
dyslipidemia
  • 6 views
  • 27 Feb, 2021
  • 2 locations
Management of Cardiovascular Disease in Kidney Disease (MaCK) Study

Cardiovascular disease (CVD) is the largest concerns for patients with Chronic kidney disease (CKD). At present time the investigators do not have proven effective strategies to reduce high CVD related deaths in CKD. This study assesses a novel therapy (hydroxychloroquine, HCQ) for the treatment of CVD in patients with CKD. …

diabetes
chronic disease
cardiovascular disease
nephropathy
albumin/creatinine ratio
  • 3 views
  • 29 Apr, 2021
  • 1 location
The CREST-2 Registry

determined by a multi-specialty Interventional Management Committee (IMC). Patient eligibility will include patients with standard or high-risk, symptomatic or asymptomatic carotid artery disease. Patients

stenosis
stroke
amaurosis fugax
ischemic attack
neurologic symptoms
  • 94 views
  • 24 Jan, 2021
  • 1 location
SVS VQI TransCarotid Revascularization Surveillance Project

The VQI TCAR Surveillance Project is designed to monitor the safety and effectiveness of stents placed directly into the carotid artery while reversing blood flow within the carotid artery to reduce stroke risk. It will compare this less-invasive surgical procedure with standard carotid endarterectomy in centers that participate in the …

coronary disease
radical neck dissection
myocardial infarction
endarterectomy
carotid artery occlusion
  • 10 views
  • 11 Mar, 2021
  • 1 location
OPTIMAl Endovascular Exclusion of Consecutive Patient High-risk Carotid Plaque Using the MicroNet Covered Stent

Night-time micturition, called nocturia, is a very common problem that unfavourably influences sleep- and life-qualities. The International Continence Society (ICS) defines nocturia as micturition once or several times during the night. Nocturia is one of the cardinal symptoms of overactive bladder (OAB). Persons with nocturia have the intention to continue …

stenosis
carotid artery stenosis
  • 0 views
  • 25 Jan, 2021
  • 1 location
3D Multi-Contrast Atherosclerosis Characterization of the Carotid Artery

This is a technical development study with the goal to develop 3D techniques for atherosclerosis plaque characterization. We hypothesize that 3D MRI is superior to 2D MRI in characterizing major plaque constituents that contribute to severe clinical events such as myocardial infarction or stroke. The major advantages of the 3D …

stroke
myocardial infarction
cardiovascular disease
atherosclerosis
MRI
  • 31 views
  • 25 Jan, 2021
  • 1 location
SmartRisk Stroke Prediction by MRI of Carotid Disease

Atherosclerotic plaque at the carotid artery bifurcation is a major source of stroke. The purpose of this investigation is to determine the ability of the SmartRisk software module to predict stroke or stroke-related events due to carotid plaque within a high-risk population. The SmartRisk software module operates on magnetic resonance …

stroke
stenosis
carotid disease
MRI
  • 211 views
  • 07 Nov, 2020
  • 14 locations
The Changes in Carotid Plaque Neovascularization After Elovocumab Therapy

150 selected patients will be recruited, who have at least one atherosclerotic plaque in the carotid artery that is thicker than 2.0 mm and which is determined to be uniformly or predominantly echolucent by standard ultrasonography. For each of the plaques, standard ultrasonography will be used to evaluate lesion echogenicity, …

  • 0 views
  • 28 Apr, 2021
  • 1 location