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Found 64 clinical trials
MicroNet-covered Stent System for Stroke Prevention in All Comer Carotid Revascularization

All-comer study of unselected patients suitable for carotid artery revascularization to evaluate the feasibility, efficacy and safety of first line endovascular revasculariztion using MicroNet covered stent (CGuard) in the treatment of consecutive symptomatic and increased-stroke-risk asymptomatic carotid lesions that require revascularization by Neurovascular Team decision.

angiography
amaurosis fugax
atherosclerosis
carotid revascularization
ischemic attack
  • 1 views
  • 23 Jan, 2021
  • 1 location
CARotid plaqUe StabilizatiOn and Regression With Evolocumab.

The CARUSO trial aims at investigating the efficacy of evolocumab in promoting carotid plaque morphological stabilization and regression as compared to traditional lipid lowering therapy (LLT). Primary end-point of the study is the superiority of evolocumab on top of ongoing LLT versus ongoing LLT in carotid plaque morphological stabilization and …

  • 0 views
  • 04 Feb, 2021
  • 1 location
Comparison of Spectral Photon Counting CT (SPCCT) With Dual Energy CT (DECT) and Magnetic Resonance Imaging (MRI) for Plaque and Lumen Carotid Arteries Evaluation

vulnerable plaques and luminal stenosis in Carotid Atherosclerosis patients compared to DECT (Dual Energy CT) and MRI (Magnetic Resonance Imaging) which are used in current practice

  • 0 views
  • 05 May, 2021
  • 1 location
Effect of Short Term Atorvastatin Treatment 80mg/Day on Early Regression of Carotid Artery Atherosclerotic Lesions

tissues.Blockage of the carotid arteries in the neck is a major cause of stroke. One way of treating carotid atherosclerosis is with cholesterol-lowering drugs called statins. Statins have been shown to

endarterectomy
hmg-coa reductase inhibitor
diabetes
atorvastatin
atherosclerosis
  • 24 views
  • 07 Nov, 2020
  • 1 location
Ticagrelor Versus Clopidogrel in Carotid Artery Stenting

Patients with symptomatic or asymptomatic carotid stenosis in whom carotid artery stenting is planned are randomised between antiplatelet therapy with ticagrelor plus aspirin or clopidogrel plus aspirin and examined with brain MRI before and after stent treatment. The proportion of patients with new ischaemic lesions on MRI after treatment is …

amaurosis fugax
clopidogrel
aspirin
transient ischemic attack
atherosclerosis
  • 52 views
  • 03 Feb, 2021
  • 21 locations
SONOlysis in Prevention of Brain InfaRctions During Internal Carotid Endarterectomy

SONOBIRDIE Trial is a randomized, single-blind, sham-controlled study designed for a demonstration of the safety and effectiveness of sonolysis (continual transcranial Doppler (TCD) monitoring) in reduction of risk of stroke or transient ischemic attack (TIA), brain infarctions and cognitive decline using a 2-MHz diagnostic probe with a maximal diagnostic energy …

endarterectomy
angiography
ischemic attack
carotid artery stenosis
stenosis
  • 6 views
  • 26 Jan, 2021
  • 2 locations
Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asymptomatic high-grade carotid stenosis. One trial will randomize patients in a 1:1 ratio to endarterectomy versus no endarterectomy and another will …

endarterectomy
angiography
transient ischemic attack
carotid revascularization
ischemic attack
  • 1024 views
  • 03 May, 2021
  • 145 locations
Statin Neuroprotection and Carotid Endarterectomy: Safety Feasibility and Outcomes

The investigators hypothesize that pre-operative statin use is neuroprotective at maximal doses. The goals are to determine the safety, feasibility, and efficacy of maximizing statin doses for two weeks (12-18 days) prior to CEA using change in performance on a battery neuropsychometric tests as outcome measure. Study will recruit patients …

endarterectomy
arterial stenosis
atorvastatin
ischemia
statin
  • 14 views
  • 21 Jan, 2021
  • 6 locations
Carotid Atherosclerosis : Innovative Imaging Biomarkers. Study Case-control

Cerebrovascular accident (CVA) constitutes a major health public problem. This represents the second cardiovascular death cause. CVA is ischemic in 80% of cases. Atheroma of large arteries, mainly carotid, is involved in about 20% of cases. After several high grade studies (NASCET, ECST, ACAS, ACST), carotid surgery is based on …

endarterectomy
transcranial doppler ultrasonography
angiography
magnetic resonance angiography
doppler ultrasound
  • 0 views
  • 05 Mar, 2021
  • 1 location
Individualized Physical Activity and Carotid Plaque Instability

Intraplaque hemorrhage (IPH) is one of the main features of the carotid plaque instability's and predictor of ischemic stroke. Benefits (on the basis on benefit/risk ratio) of the carotid endarterectomy remain unclear for stroke asymptomatic patients; thus, more and more patients with important stenosis (i.e. over 60%) detected are not …

endarterectomy
atherosclerosis
vascular surgery
stenosis
MRI
  • 0 views
  • 23 Jan, 2021
  • 1 location