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Found 18 clinical trials
Role of Perhexiline in Hypertrophic Cardiomyopathy

, symptom relief is often incomplete and there is no evidence on the benefit of -blockers or related medications to reverse LVH. Perhexiline, a potent carnitine palmitoyl transferase-1 (CPT-1) inhibitor

  • 19 Mar, 2021
  • 1 location
Levocarnitine for Dry Eye in Sjogren's Syndrome

This study evaluates the effectiveness of levocarnitine in the treatment of dry eye in adults with Sjogren's syndrome. This will be a crossover study design with all participants receiving both levocarnitine and placebo.

  • 24 Mar, 2022
  • 1 location
Isoleucine Intake and Intermediary Metabolism in Type 2 Diabetes

The primary objective of this study is to determine the mechanism of reduced branched-chain amino acid (BCAA) oxidation to propionyl CoA and isoleucine intake can affect TCA cycle function in obese insulin resistant T2D. We will test the hypotheses that isoleucine and valine oxidation to propionyl CoA is reduced and …

body mass index
Accepts healthy volunteers
  • 19 Dec, 2021
  • 1 location
Efficacy Comparison of Tamoxifen and Tamoxifen With Antioxidants on Semen Quality of Male With Idiopathic Infertility

Objective of the study is to compare the efficacy of tamoxifen alone & tamoxifen with antioxidant on semen quality of infertile male with abnormal parameters (sperm count, motility, vitality, morphology) .Infertility is defines as inability to conceive after one year of unprotected and regular intercourse. Infertility is the most important …

Accepts healthy volunteers
  • 25 Mar, 2022
Measuring Fatty Acid Oxidation in Cerebral Metastases Using [18F]FPIA

Cerebral metastases represent a significant problem for oncological management. It is estimated that 20-40% of patients with cancer will develop metastatic cancer to the brain during the course of their illness. 18F-fluoropivalate ([18F]FPIA) is a new tracer that images short chain fatty acid (SCFA) uptake in tumours, a key component …

  • 26 Mar, 2021
  • 1 location
Biomarkers in Infection

The purpose of this investigation is to evaluate how early biomarkers of infection and inflammation perform in identifying patients at risk for poor outcome in sepsis and septic shock.

white blood cell count
septic shock
  • 23 Jan, 2021
  • 4 locations
Acylcarnitine Profile After Intensive Care

The aim of the study is to compare the acylcarnitine profile of critically ill survivors of a prolonged stay in ICU with the profile of survivors of short ICU length of stay. The second aim is to assess the evolution of the acylcarnitine profile over time in survivors of a …

  • 01 Dec, 2021
  • 1 location
Fatty Liver Patient Registry

The purpose of the Non-Alcoholic Fatty Liver Disease (NAFLD) registry is to collect demographic and clinical data on patients being treated for NAFLD and to determine the factors affecting the progression of the disease as well as the success of different treatment strategies.

liver disease
fatty liver
  • 17 Jul, 2021
  • 1 location