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Found 537 clinical trials
Featured trial
RB-ADSC for Treatment of Mild to Moderate Alzheimer's Disease

The Primary objective of this phase 1 research study is to evaluate the safety of different(escalating) doses of the participant’s own stem cells as a part of our ongoing researchinto an effective “whole brain” treatment for Alzheimer disease, with secondaryobjectives to evaluate preliminary efficacy, in order to determine a recommended …

  • 06 Sep, 2023
  • 1 location
Featured trial
Pilot Study of Topical Dexamethasone 0.01% Solution for Prevention of Oral Chronic Graft Versus Host Disease

This study will determine if a dexamethasone mouth rinse can reduce the risk of developing oral chronic graft-versus-host disease (cGVHD) in patients who have undergone a bone marrow (stem cell) transplant procedure. cGVHD is a common complication of stem cell transplantation, resulting from the donor cells attacking the transplant recipient's …

graft-versus-host disease
graft versus host disease
  • 22 Dec, 2020
  • 1 location
Featured trial


  • 23 Nov, 2020
  • 10 locations
Study of Pembrolizumab (MK-3475) Combination Therapies in Metastatic Castration-Resistant Prostate Cancer (MK-3475-365/KEYNOTE-365)

The purpose of this study is to assess the safety and efficacy of pembrolizumab (MK-3475) combination therapy in participants with metastatic castration resistant prostate cancer (mCRPC). There will be ten cohorts in this study: Cohort A will receive pembrolizumab + olaparib, Cohort B will receive pembrolizumab + docetaxel + prednisone, …

androgen suppression
receptor activator of nuclear factor kappa-b ligand
bone lesions
  • 12 Sep, 2023
  • 43 locations
Phase 2/3 Adaptive Study of VX-147 in Adults and Adolescents With APOL1- Mediated Proteinuric Kidney Disease

The purpose of this study is to evaluate the efficacy, safety, tolerability and pharmacokinetics (PK) of VX-147 in participants aged 12 years and older with apolipoprotein L1 (APOL1)-mediated proteinuric kidney disease.

  • 27 Aug, 2023
  • 143 locations
A Study to Evaluate the Efficacy and Safety of Giredestrant in Combination With Phesgo (Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf) Versus Phesgo in Participants With Locally Advanced or Metastatic Breast Cancer (heredERA Breast Cancer)

This Phase III, randomized, two-arm, open-label, multicenter study will evaluate the efficacy and safety of giredestrant plus Phesgo compared with Phesgo after induction therapy with Phesgo plus taxane in participants with human epidermal growth factor receptor 2 (HER2)-positive, estrogen receptor (ER)-positive advanced breast cancer (metastatic or locally advanced disease not …

  • 10 Sep, 2023
  • 137 locations
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (CIRCULATE-US)

This Phase II/III trial will evaluate the what kind of chemotherapy to recommend to patients based on the presence or absences of circulating tumor DNA (ctDNA) after surgery for colon cancer.

  • 08 Apr, 2023
  • 596 locations
Toothbrushing Program in Saudi Arabia "TOPS"

Project summary Introduction: Dental caries is a major oral health problem worldwide. In children, dental caries is especially critical; it causes pain, infection and impacts on quality

Accepts healthy volunteers
  • 04 Oct, 2022
  • 1 location
Selective Removal Technique With or Without a Bioactive Material for Deep Caries Lesions

pulp capping material in patients with deep caries lesions in mature permanent posterior teeth with normal or reversible pulpitis after a 2 year follow-up. Evaluate the integrity of the resin composite

  • 17 Feb, 2021
  • 1 location
Clinical Analysis of a Risk-graded and Comprehensive Intervention for Early-childhood-caries

Cariogram and Cariostat will be used to assess the risk of caries in kindergarten children aged 3 years. Routine preventive measures will be taken for children at low risk of caries, and

Accepts healthy volunteers
  • 04 Oct, 2022
  • 1 location