Found 537 clinical trials
RB-ADSC for Treatment of Mild to Moderate Alzheimer's Disease
The Primary objective of this phase 1 research study is to evaluate the safety of different(escalating) doses of the participant’s own stem cells as a part of our ongoing researchinto an effective “whole brain” treatment for Alzheimer disease, with secondaryobjectives to evaluate preliminary efficacy, in order to determine a recommended …
- 0 views
- 06 Sep, 2023
- 1 location
Pilot Study of Topical Dexamethasone 0.01% Solution for Prevention of Oral Chronic Graft Versus Host Disease
This study will determine if a dexamethasone mouth rinse can reduce the risk of developing oral chronic graft-versus-host disease (cGVHD) in patients who have undergone a bone marrow (stem cell) transplant procedure. cGVHD is a common complication of stem cell transplantation, resulting from the donor cells attacking the transplant recipient's …
- 164 views
- 22 Dec, 2020
- 1 location
Study of Pembrolizumab (MK-3475) Combination Therapies in Metastatic Castration-Resistant Prostate Cancer (MK-3475-365/KEYNOTE-365)
The purpose of this study is to assess the safety and efficacy of pembrolizumab (MK-3475) combination therapy in participants with metastatic castration resistant prostate cancer (mCRPC). There will be ten cohorts in this study: Cohort A will receive pembrolizumab + olaparib, Cohort B will receive pembrolizumab + docetaxel + prednisone, …
- 3 views
- 12 Sep, 2023
- 43 locations
Phase 2/3 Adaptive Study of VX-147 in Adults and Adolescents With APOL1- Mediated Proteinuric Kidney Disease
The purpose of this study is to evaluate the efficacy, safety, tolerability and pharmacokinetics (PK) of VX-147 in participants aged 12 years and older with apolipoprotein L1 (APOL1)-mediated proteinuric kidney disease.
- 14 views
- 27 Aug, 2023
- 143 locations
A Study to Evaluate the Efficacy and Safety of Giredestrant in Combination With Phesgo (Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf) Versus Phesgo in Participants With Locally Advanced or Metastatic Breast Cancer (heredERA Breast Cancer)
This Phase III, randomized, two-arm, open-label, multicenter study will evaluate the efficacy and safety of giredestrant plus Phesgo compared with Phesgo after induction therapy with Phesgo plus taxane in participants with human epidermal growth factor receptor 2 (HER2)-positive, estrogen receptor (ER)-positive advanced breast cancer (metastatic or locally advanced disease not …
- 2 views
- 10 Sep, 2023
- 137 locations
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (CIRCULATE-US)
This Phase II/III trial will evaluate the what kind of chemotherapy to recommend to patients based on the presence or absences of circulating tumor DNA (ctDNA) after surgery for colon cancer.
- 0 views
- 08 Apr, 2023
- 596 locations
Toothbrushing Program in Saudi Arabia "TOPS"
Project summary Introduction: Dental caries is a major oral health problem worldwide. In children, dental caries is especially critical; it causes pain, infection and impacts on quality
- 0 views
- 04 Oct, 2022
- 1 location
Selective Removal Technique With or Without a Bioactive Material for Deep Caries Lesions
pulp capping material in patients with deep caries lesions in mature permanent posterior teeth with normal or reversible pulpitis after a 2 year follow-up. Evaluate the integrity of the resin composite
- 0 views
- 17 Feb, 2021
- 1 location
Clinical Analysis of a Risk-graded and Comprehensive Intervention for Early-childhood-caries
Cariogram and Cariostat will be used to assess the risk of caries in kindergarten children aged 3 years. Routine preventive measures will be taken for children at low risk of caries, and
- 0 views
- 04 Oct, 2022
- 1 location