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Found 6032 clinical trials
Home Based Tele-exercise for People With Chronic Neurological Impairments (Telex)

To assess the impact of a 12-week virtual seated physical intervention on cardiovascular health and wellness in people with chronic neurological impairments (CNI).

  • 150 views
  • 16 Jun, 2022
  • 1 location
A Study of CART-TnMUC1 in Patients With TnMUC1-Positive Advanced Cancers

Multi-center, open-label, first in human Phase 1 study of the safety, tolerability, feasibility, and preliminary efficacy of the administration of genetically modified autologous T cells (CART-TnMUC1 cells) engineered to express a chimeric antigen receptor (CAR) capable of recognizing the tumor antigen, TnMUC1 and activating the T cell (CARTTnMUC 1 cells).

ejection fraction
HER2
fludarabine
proteasome inhibitor
targeted therapy
  • 39 views
  • 10 May, 2022
  • 10 locations
Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in People With Metastatic Cancer

Background A person s tumor is studied for mutations. When cells are found that can attack the mutation in a person s tumor, the genes from those cells are studied to find the parts that make the attack possible. White blood cells are then taken from the person s body, …

white blood cells
recurrent glioblastoma
fludarabine
oxaliplatin
cytotoxic agents
  • 69 views
  • 17 Jun, 2022
  • 1 location
Tissue Collection for Studies of Lymph Cancer

Background Lab studies help researchers better understand cancer biology. This information may lead to new methods for diagnosing or treating cancer. To develop these studies, researchers want to collect samples from people with cancer or precancer conditions of the lymph system. These conditions include multiple myeloma, different types of lymphoma, …

platelet count
bone marrow procedure
leukemia
diffuse large b-cell lymphoma
apheresis
  • 205 views
  • 27 Jun, 2022
  • 1 location
The Prospective Collection Storage and Reporting of Data on Patients Undergoing Hematopoietic Stem Cell Transplantation Utilizing a Standard Preparative Regimen

To provide the IRB approved mechanism for the prospective collection, analysis and reporting of data on patients who are undergoing either an autologous or allogeneic hematopoietic stem cell transplant for a disease in which a research question is not being addressed and for which peer reviewed, published data have demonstrated …

bone marrow procedure
bone marrow transplant
stem cell transplantation
cell transplantation
  • 40 views
  • 02 Dec, 2021
  • 1 location
Reduced Intensity Chemotherapy and Radiation Therapy Before Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies

This clinical trial studies the use of reduced intensity chemotherapy and radiation therapy before donor stem cell transplant in treating patients with hematologic malignancies. Giving low doses of chemotherapy, such as cyclophosphamide and fludarabine phosphate, before a donor stem cell transplant may help stop the growth of cancer cells. It …

stem cell transplantation
fludarabine
refractory anemia with excess blasts-2
lymphoma
refractory anemia with ringed sideroblasts
  • 66 views
  • 20 Apr, 2022
  • 1 location
Ascertainment of Families for Genetic Studies of Familial Lymphoproliferative Disorders

The purpose of this study is to better understand the genetic causes of Hodgkin's disease (a kind of lymphoma) and non-Hodgkin's lymphoma, as well as multiple myeloma, leukemia, and related diseases. The doctors have identified the patient because 1) they have had a lymphoproliferative disorder such as lymphoma, leukemia, or …

leukemia
hodgkin's disease
lymphoma
Accepts healthy volunteers
cancer
  • 41 views
  • 23 Jan, 2022
  • 6 locations
A Study of Nemtabrutinib (MK-1026) (ARQ 531) in Participants With Selected Hematologic Malignancies

This study aims to evaluate the safety, tolerability, pharmacodynamic, and pharmacokinetic (PK) of nemtabrutinib (formerly ARQ 531) tablets in selected participants with relapsed or refractory hematologic malignancies. No formal hypothesis testing will be performed for this study.

platelet count
lymphocytic leukemia
mantle cell lymphoma
lymphoma
marginal zone lymphoma
  • 420 views
  • 15 Mar, 2022
  • 10 locations
BR101801 in Adult Patients With Advanced Hematologic Malignancies( Phase I-II)

This is a Phase I-II, multi-center, open-label, FIH study comprising of 3 study parts (Phase Ia, Phase Ib, and Phase II). The Phase Ia (dose escalation) part of the study is designed to determine the safety, tolerability, and maximum tolerated dose (MTD)/recommended dose for expansion (RP2D) of BR101801 in subjects …

lymphocytic leukemia
mantle cell lymphoma
diffuse large b-cell lymphoma
marginal zone lymphoma
lymphoma
  • 17 views
  • 08 Dec, 2021
A Clinical Trial of BP1002 in Patients With Advanced Lymphoid Malignancies

This study evaluates the safety, pharmacokinetics, and efficacy of BP1002 (L-Bcl-2) antisense oligonucleotide in patients with advanced lymphoid malignancies. Up to 12 evaluable patients with a diagnosis of relapsed or refractory lymphoid malignancies are expected to participate.

stem cell transplantation
mantle cell lymphoma
anticancer agents
diffuse large b-cell lymphoma
marginal zone lymphoma
  • 0 views
  • 03 Feb, 2021
  • 3 locations