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Found 6206 clinical trials
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The RADIANCE II Pivotal Study: A Study of the ReCor Medical Paradise System in Stage II Hypertension

The objective of the RADIANCE II Pivotal study is to demonstrate the effectiveness and safety of the Paradise System in subjects with Stage 2 hypertension on 0-2 medications at the time of consent. Prior to randomization, subjects will be hypertensive in the absence of hypertension medication.

antihypertensive drugs
hypertension
antihypertensive therapy
angiography
hypertensive medication
  • 877 views
  • 01 Aug, 2021
  • 83 locations
featured
C1071003 MagnetisMM-3  

The purpose of the study is to evaluate whether single-agent PF-06863135 can provide clinical benefit in participants with relapsed/refractory multiple myeloma. PF-06863135 is a bispecific antibody: binding of PF-06863135 to CD3-expressing T-cells and BCMA-expressing multiple myeloma cells causes targeted T-cell-mediated cytotoxicity.

refractory multiple myeloma
  • 0 views
  • 30 Jul, 2021
  • 3 locations
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Inflammatory Characterization of Known or Possible Cardiovascular Diseases

Background: Cardiometabolic diseases are a combination of medical disorders that, when they occur together, increase the risk of heart disease and diabetes. Researchers want to learn if there is a relationship between these diseases and inflammation (redness, swelling, and pain). Inflammation affects the entire body. Researchers will study this relationship …

heart disease
diabetes
fats
  • 46 views
  • 23 Nov, 2020
  • 1 location
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Human Translational Studies of Inflammation and Cardiometabolic Diseases: The Psoriasis, Atherosclerosis and Cardiometabolic Disease (PACI) Initiative

Background: Cardiometabolic diseases are medical disorders that can occur together and affect the heart. They increase the risk of developing heart disease and diabetes. One disorder, psoriasis, is an inflammation that mostly affects the skin but can affect the entire body. Another disorder, atherosclerosis, is a process in which cholesterol …

heart disease
diabetes
atherosclerosis
cholesterol measurement
  • 47 views
  • 23 Nov, 2020
  • 1 location
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Dietary Omega-7 Palmitoleic Acid-Rich Oil on Lipoprotein Metabolism and Satiety in Adults

oil enriched with palmitoleic acid (Omega-7 oil) affects metabolism. Eligibility: Healthy adults at least 18 years old with no known history of cardiovascular

fish oil
fatty acids
  • 39 views
  • 23 Nov, 2020
  • 1 location
featured
HPS-4/TIMI 65/ORION-4: A double-blind randomized placebo-controlled trial assessing the effects of inclisiran on clinical outcomes among people with atherosclerotic cardiovascular disease

The ORION-4 clinical trial aims to test a new, twice annual cholesterol injectable medication called inclisiran which has no known side effects. Inclisiran is a PCSK9 gene inhibitor that prevents the PCSK9 from circulating and destroying the body's LDL ("bad" cholesterol) receptors which digest LDL. Inclisiran enhances the effects of …

  • 97 views
  • 11 Jun, 2020
  • 1 location
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Cardiovascular Disease Discovery Protocol

individuals who have or are at risk for cardiovascular diseases, as well as their unaffected relatives and healthy volunteers. Eligibility: Individuals between 2 and

angiography
  • 327 views
  • 08 Apr, 2019
  • 1 location
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Type 2 Diabetes with Cardiovascular Disease

Research study for those with Type 2 Diabetes AND Cardiovascular Disease.

  • 0 views
  • 08 Mar, 2021
  • 1 location
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Type 2 Diabetes and Cardiovascular Disease

Type 2 Diabetes and Cardiovascular Disease

  • 64 views
  • 08 Nov, 2020
  • 1 location
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Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Skeletal Muscle Function in Heart Failure Subjects

Background: People are living longer and are more likely to survive a heart attack if they have one. Longer life expectancy is good but it also means more people get chronic heart failure over time. This is a condition in which the heart doesn't pump blood as well as it …

chronic heart failure
systolic heart failure
radionuclide ventriculography
cardiopulmonary exercise testing
heart failure
  • 77 views
  • 09 Apr, 2019
  • 1 location