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Found 6176 clinical trials
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The RADIANCE II Pivotal Study: A Study of the ReCor Medical Paradise System in Stage II Hypertension

The objective of the RADIANCE II Pivotal study is to demonstrate the effectiveness and safety of the Paradise System in subjects with Stage 2 hypertension on 0-2 medications at the time of consent. Prior to randomization, subjects will be hypertensive in the absence of hypertension medication.

antihypertensive therapy
antihypertensive drugs
renal angiogram
hypertensive medication
angiography
  • 877 views
  • 13 May, 2021
  • 78 locations
featured
Inflammatory Characterization of Known or Possible Cardiovascular Diseases

Background: Cardiometabolic diseases are a combination of medical disorders that, when they occur together, increase the risk of heart disease and diabetes. Researchers want to learn if there is a relationship between these diseases and inflammation (redness, swelling, and pain). Inflammation affects the entire body. Researchers will study this relationship …

diabetes
heart disease
fats
  • 46 views
  • 23 Nov, 2020
  • 1 location
featured
Human Translational Studies of Inflammation and Cardiometabolic Diseases: The Psoriasis, Atherosclerosis and Cardiometabolic Disease (PACI) Initiative

Background: Cardiometabolic diseases are medical disorders that can occur together and affect the heart. They increase the risk of developing heart disease and diabetes. One disorder, psoriasis, is an inflammation that mostly affects the skin but can affect the entire body. Another disorder, atherosclerosis, is a process in which cholesterol …

diabetes
atherosclerosis
cholesterol measurement
heart disease
  • 47 views
  • 23 Nov, 2020
  • 1 location
featured
Dietary Omega-7 Palmitoleic Acid-Rich Oil on Lipoprotein Metabolism and Satiety in Adults

oil enriched with palmitoleic acid (Omega-7 oil) affects metabolism. Eligibility: Healthy adults at least 18 years old with no known history of cardiovascular

fish oil
fatty acids
  • 39 views
  • 23 Nov, 2020
  • 1 location
featured
HPS-4/TIMI 65/ORION-4: A double-blind randomized placebo-controlled trial assessing the effects of inclisiran on clinical outcomes among people with atherosclerotic cardiovascular disease

The ORION-4 clinical trial aims to test a new, twice annual cholesterol injectable medication called inclisiran which has no known side effects. Inclisiran is a PCSK9 gene inhibitor that prevents the PCSK9 from circulating and destroying the body's LDL ("bad" cholesterol) receptors which digest LDL. Inclisiran enhances the effects of …

  • 97 views
  • 11 Jun, 2020
  • 1 location
featured
Cardiovascular Disease Discovery Protocol

individuals who have or are at risk for cardiovascular diseases, as well as their unaffected relatives and healthy volunteers. Eligibility: Individuals between 2 and

angiography
  • 327 views
  • 08 Apr, 2019
  • 1 location
featured
Type 2 Diabetes with Cardiovascular Disease

Research study for those with Type 2 Diabetes AND Cardiovascular Disease.

  • 0 views
  • 08 Mar, 2021
  • 1 location
featured
Type 2 Diabetes and Cardiovascular Disease

Type 2 Diabetes and Cardiovascular Disease

  • 64 views
  • 08 Nov, 2020
  • 1 location
featured
Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Skeletal Muscle Function in Heart Failure Subjects

Background: People are living longer and are more likely to survive a heart attack if they have one. Longer life expectancy is good but it also means more people get chronic heart failure over time. This is a condition in which the heart doesn't pump blood as well as it …

systolic heart failure
radionuclide ventriculography
heart failure
chronic heart failure
cardiopulmonary exercise testing
  • 77 views
  • 09 Apr, 2019
  • 1 location
featured
Williams Syndrome (WS) and Supravalvular Aortic Stenosis (SVAS) DNA and Tissue Bank

Background: DNA tells the body how to grow and function. Williams-Beuren syndrome (WS) and Supravalvular Aortic Stenosis (SVAS) are rare diseases caused by changes in a part of a person's DNA. Symptoms of both conditions include vascular problems including narrow blood vessels and supravalvular aortic stenosis (SVAS) or supravalvular pulmonary …

rare diseases
stenosis
supravalvular aortic stenosis
  • 48 views
  • 23 Nov, 2020
  • 1 location