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Found 95 clinical trials
Jafron Haemoadsorption During Cardiopulmonary Bypass (JAFRONCPB)

Cardiopulmonary bypass (CPB) is often associated with degrees of complex inflammatory response mediated by various cytokines. This response can, in severe cases, lead to systemic hypotension and

  • 11 Jul, 2022
  • 1 location
Assessing the Hemostatic Efficacy of Pathogen Reduced Platelets in Children Undergoing Cardiopulmonary Bypass Surgery: A Pilot Clinical Trial (PEDITREC)

This study is testing whether pathogen reduced platelets can control bleeding as well as non-pathogen reduced platelets (otherwise known as large volume delayed sampling).

  • 21 Jul, 2022
  • 1 location
HPI (Hypotension Prediction Index) Care Trial

in cardiac surgery patients requiring cardiopulmonary bypass.

  • 23 Apr, 2022
  • 1 location
Comparing Hypothermic Temperatures During Hemiarch Surgery (TITAN:COMMENCE)

visceral organs, but may result in longer cardiopulmonary bypass times during surgery, increased risks of bleeding, inflammation, and neuronal injury. To manage these consequences, a trend towards warmer

  • 10 May, 2022
  • 4 locations
Platelets or Fibrinogen as First-line Treatment for Bleeding During Pedatric Heart Surgery

The study aims to test whether platelet transfusion or fibrinogen concentrate is the most effective treatment of intraoperative bleeding, when performing open heart surgery with cardiopulmonary

  • 25 Mar, 2021
  • 1 location
Emergency Preservation and Resuscitation (EPR) for Cardiac Arrest From Trauma (EPR-CAT)

control of bleeding, followed by delayed resuscitation with cardiopulmonary bypass.

  • 08 Jul, 2022
  • 1 location
Mesenchymal Stromal Cells for Infants With Congenital Heart Disease (MedCaP)

cardiopulmonary bypass (CPB) using a homogeneous population of infants with congenital heart disease (CHD) who will be undergoing a two-ventricle repair within the first six months of life

  • 29 May, 2022
  • 1 location
High-exchange ULTrafiltration to Enhance Recovery After Pediatric Cardiac Surgery

of individuals with congenital heart disease is highly complex and has significant risks of morbidity and mortality. Most cardiac operations require the use of cardiopulmonary bypass (CPB, also known

  • 04 Nov, 2021
  • 1 location
Spanish Randomized Clinical Trial to Compare Levosimendan Versus Placebo in Postoperative Cardiac Surgery (SPARTANS)

Low cardiac output Syndrome (LCOS) is a complication that appears in approximately 20% of cardiac surgeries with extracorporeal circulation. LCOS is associated with increased mortality, delayed recovery and prolonged hospital stay. The Spanish Randomized Clinical Trial on Levosimendan (brand name: Sindax) (SPARTANS) aims to demonstrate the effectiveness of the preoperative …

  • 25 Jan, 2021
  • 8 locations
The Role of Ketamine and Dexmedetomidine in Opioid-Sparing Analgesia

Optimal multimodal opioid-sparing analgesic technique is considered as one of the most important Enhanced recovery pathways (ERPs) or enhanced recovery after surgery (ERAS) interventions that mitigate the undesirable effects of surgical stress response. Implementation of ERP has been shown to reduce postoperative complications and shorten the hospital LOS.

Accepts healthy volunteers
  • 09 Aug, 2022
  • 1 location