Found 288 clinical trials
Mechanisms of Excess Risk in Aortic Stenosis
Aortic stenosis (AS) is caused by narrowing of one of the main heart valves. Replacing the valve is the only treatment to prevent the heart from failing or death. The timing of replacement is currently often too late - half of patients are left with permanent scarring and a quarter …
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- 07 May, 2021
- 1 location
Atrial Fibrillation Patients Treated With Catheter Ablation
This is a single-center prospective observational cohort study of atrial fibrillation patients treated with radiofrequency ablation.
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- 12 Mar, 2022
- 1 location
Progression of Atrial Fibrillation in the Young
The purpose of this study is to investigate the presence and magnitude of structural changes of the heart and their long-term development in young patients with atrial Fibrillation (AF), studied by echocardiographic measurements and plasma biomarkers and their association to AF burden, studied using long-term ECG
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- 24 Oct, 2021
- 1 location
Gut Microbiome and Ventricular Arrhythmias
Ventricular tachycardia and ventricular fibrillation (VT/VF) are the most common causes of sudden cardiac death in patients with diseased hearts. The factors contributing to these deadly arrhythmias are not well understood. The presence of a wide variety of microbial flora in the human GI tract, particularly colon has been well …
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- 03 May, 2022
- 1 location
Comparative Imaging Assessment of Valvular Heart Disease
The purpose of the study is to compare the various 2D and 3D methods of valvular heart disease quantification (Doppler, PISA, VCA, volumetric method) and strain with cardiac magnetic resonance (CMR) measurements of left and right ventricular systolic function strain and myocardial fibrosis assessment.
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- 24 Nov, 2021
- 1 location
The Heart Outcomes in Pregnancy Expectations (H.O.P.E) Registry
Prospective US registry of pregnant women with cardiac disease to address the substantial gaps in knowledge surrounding these patients, in order to improve future care.
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- 04 Oct, 2022
- 1 location
Myocardial Injury Following Non-cardiac Surgery (EMINENT)
It is estimated that > 200 million patients in the world undergo surgery each year of which approximately 10 million will suffer from a myocardial injury in the perioperative period. Mortality is high in patients with myocardial injury since it often goes undiagnosed and management is unclear. In contrast to …
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- 03 Jun, 2022
- 1 location
MRI-phenotyping of Patients With Pathogenic Anoctamin 5 Variants
A large cohort of MRI scans from patients with pathogenic variants in the anoctamin 5 gene will be collected through an international collaboration to better describe muscle involvement.
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- 18 Nov, 2021
- 1 location
Lenvatinib Therapy in the Patients With High-risk Hepatocellular Carcinoma After LDLT
New guidelines have been successfully established to distinguish the patients who were suitable for LT. This is important for long-term recurrence free and overall survival rate. We stratified patients with PET diagnosis and fetal protein response to confirm if they were the high-risk group for HCC recurrence. According to our …
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- 23 Oct, 2022
- 1 location
Diagnostic Potential of UCHL1 in Acute Decompensated Heart Failure
Autophagy is considered an important component of Heart failure progression. Deubiquitination enzymes play an important role in autophagy. An important regulatory process within the autophagy pathway is ubiquitination. Ubiquitination targets proteins for degradation. On the contrary, de-ubiquitinating proteins (such as UCHL1) reverses this process. Studies have demonstrated deubiquitination to be …
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- 04 Oct, 2022
- 1 location