Found 293 clinical trials
Patients with Heart Failure and currently on a loop diuretic
The purpose of this study is to evaluate the action of the study drug on your kidneys and your ability to eliminate salt and water alongside a diuretic (furosemide). The information gathered during this clinical trial may support further drug development, including larger trials in patients with heart failure. The study …
- 96 views
- 23 Nov, 2020
- 1 location
Is There a Genetic Predisposition for Acute Stress-induced (Takotsubo) Cardiomyopathy
Acute stress-induced (takotsubo) cardiomyopathy or broken heart syndrome presents like a heart attack, classically is triggered by intense emotional or physical stress and can have serious
- 4 views
- 07 Oct, 2021
- 1 location
Exploratory Study of Danicamtiv in Patients With Primary Dilated Cardiomyopathy (DCM) Due to Genetic Variants
The purpose of this Phase 2a study is to establish safety and preliminary efficacy of treatment with danicamtiv in patients with primary dilated cardiomyopathy (DCM) due to MYH7 or TTN variants
- 7 views
- 01 Jul, 2022
- 17 locations
An Extension Study to Assess Long-Term Safety of Eplontersen in Adults With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)
The purpose of this study is to evaluate the safety and tolerability of extended dosing with eplontersen in participants with ATTR-CM.
- 0 views
- 03 Apr, 2023
- 2 locations
A Multi-center, Randomized, Placebo-controlled Patient and Investigator-blinded Study to Explore the Efficacy of Oral Sacubitril/Valsartan in Adult Patients With Non-obstructive Hypertrophic Cardiomyopathy (nHCM)
The purpose of this study is to determine if LCZ696 is safe, tolerable and can improve exercise capacity (via improved peak VO2) in non-obstructive HCM patient population over the course of 50 weeks of treatment.
- 46 views
- 21 Oct, 2022
- 9 locations
Performance and Safety of the Cardiac Microcurrent Therapy System (C-MIC-II)
Patients with idiopathic dilative cardiomyopathy who have systolic left ventricular dysfunction (NYHA III - IV) despite adequate therapy according treatment guidelines of heart failure and who
- 3 views
- 04 Apr, 2023
- 14 locations
Parametric Cardiac 18F-flutemetamol PET Imaging in ATTR Cardiomyopathy
18F-Flutemetamol (Vizamyl) is a radioactive diagnostic agent indicated and FDA-approved for Positron Emission Tomography (PET) imaging of the brain to estimate β-amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimer's disease (AD) or other causes of cognitive decline. This study is designed to …
- 0 views
- 27 Oct, 2022
- 1 location
A Study of Mavacamten in Non-Obstructive Hypertrophic Cardiomyopathy (ODYSSEY_HCM)
The purpose of this study is to evaluate the safety, tolerability, and efficacy of mavacamten compared with placebo in participants with symptomatic non-obstructive hypertrophic cardiomyopathy
- 0 views
- 03 Apr, 2023
- 3 locations
Life-style Interventions for Modulating the Brain Phenotype of Takotsubo Cardiomyopathy (BREAKOUT)
Takotsubo cardiomyopathy presents like a heart attack and is typically triggered by intense emotional or physical stress. Recovery of this condition varies and many patients continue to suffer
- 0 views
- 07 Oct, 2022
- 1 location
Early Treatment With Candesartan vs Placebo in Genetic Carriers of Dilated Cardiomyopathy (EARLY-GENE Trial) (EARLY-GENE)
Cardiomyopathy (DCM) in genetic carriers of a DCM-causing variant without disease expression (asymptomatic)
- 0 views
- 07 Oct, 2022
- 1 location