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Found 296 clinical trials
Featured trial
B3461087 - Tafamidis

This study is a global, multi-center study designed to estimate the global prevalence of transthyretin amyloid cardiomyopathy (ATTR-CM) within a clinically at risk population [participants with

  • 0 views
  • 09 Jun, 2022
  • 5 locations
Featured trial
Patients with Heart Failure and currently on a loop diuretic

The purpose of this study is to evaluate the action of the study drug on your kidneys and your ability to eliminate salt and water alongside a diuretic (furosemide). The information gathered during this clinical trial may support further drug development, including larger trials in patients with heart failure.  The study …

furosemide
fatigue
heart failure
  • 96 views
  • 23 Nov, 2020
  • 1 location
Is There a Genetic Predisposition for Acute Stress-induced (Takotsubo) Cardiomyopathy

Acute stress-induced (takotsubo) cardiomyopathy or broken heart syndrome presents like a heart attack, classically is triggered by intense emotional or physical stress and can have serious

  • 4 views
  • 07 Oct, 2021
  • 1 location
First-in-Human Study of NI006 in Patients With Amyloid Transthyretin Cardiomyopathy

extension phase in subjects with Amyloid Transthyretin Cardiomyopathy (ATTR-CM).

  • 34 views
  • 30 Jun, 2022
  • 6 locations
Exploratory Study of Danicamtiv in Patients With Primary Dilated Cardiomyopathy (DCM) Due to Genetic Variants

The purpose of this Phase 2a study is to establish safety and preliminary efficacy of treatment with danicamtiv in patients with primary dilated cardiomyopathy (DCM) due to MYH7 or TTN variants

  • 7 views
  • 01 Jul, 2022
  • 17 locations
A Multi-center, Randomized, Placebo-controlled Patient and Investigator-blinded Study to Explore the Efficacy of Oral Sacubitril/Valsartan in Adult Patients With Non-obstructive Hypertrophic Cardiomyopathy (nHCM)

The purpose of this study is to determine if LCZ696 is safe, tolerable and can improve exercise capacity (via improved peak VO2) in non-obstructive HCM patient population over the course of 50 weeks of treatment.

exercise test
hypertrophic obstructive cardiomyopathy
cardiopulmonary exercise testing
cpet
nt-probnp
  • 46 views
  • 21 Oct, 2022
  • 9 locations
Prospective, Randomized, Open, Comparison Study to Demonstrate the Performance and the Safety of Cardiac Microcurrent Therapy (C-MIC) System (C-MIC-II)

Patients with idiopathic dilative cardiomyopathy who have systolic left ventricular dysfunction (NYHA III - IV) despite adequate therapy according treatment guidelines of heart failure and who

  • 3 views
  • 11 Oct, 2022
  • 8 locations
Parametric Cardiac 18F-flutemetamol PET Imaging in ATTR Cardiomyopathy

18F-Flutemetamol (Vizamyl) is a radioactive diagnostic agent indicated and FDA-approved for Positron Emission Tomography (PET) imaging of the brain to estimate β-amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimer's disease (AD) or other causes of cognitive decline. This study is designed to …

  • 0 views
  • 27 Oct, 2022
  • 1 location
Life-style Interventions for Modulating the Brain Phenotype of Takotsubo Cardiomyopathy (BREAKOUT)

Takotsubo cardiomyopathy presents like a heart attack and is typically triggered by intense emotional or physical stress. Recovery of this condition varies and many patients continue to suffer

Accepts healthy volunteers
  • 0 views
  • 07 Oct, 2022
  • 1 location
Early Treatment With Candesartan vs Placebo in Genetic Carriers of Dilated Cardiomyopathy (EARLY-GENE Trial) (EARLY-GENE)

Cardiomyopathy (DCM) in genetic carriers of a DCM-causing variant without disease expression (asymptomatic)

  • 0 views
  • 07 Oct, 2022
  • 1 location