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Found 365 clinical trials
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AnaLysIs of Both Sex and Device Specific FactoRs on Outcomes in PAtients with Non-Ischemic Cardiomyopathy - Bio Libra

Secondary Objectives All-cause mortality, VT or VF alone, risk of cardiac death, and sudden cardiac death for the total cohort, as well as by sex and by the implanted device type. Compare the predicted incidence of sudden death using the Seattle Proportional Risk score to the observed incidence in this …

shock
ejection fraction
sudden cardiac death
  • 48 views
  • 24 Nov, 2020
  • 1 location
featured
Clinical, Electrocardiographic, and Cardiac Magnetic Resonance Imaging Risk Factors Associated with Ventricular Tachyarrhythmias in Nonischemic Cardiomyopathy (MARVEN Study)

Implantable cardioverter defibrillator (ICD) for primary prevention of mortality is an approved therapy in ischemic and nonischemic cardiomyopathy patients with left ventricular ejection fraction

heart study
  • 350 views
  • 24 Nov, 2020
  • 1 location
featured
Patients with Heart Failure and currently on a loop diuretic

The purpose of this study is to evaluate the action of the study drug on your kidneys and your ability to eliminate salt and water alongside a diuretic (furosemide). The information gathered during this clinical trial may support further drug development, including larger trials in patients with heart failure.  The study …

furosemide
fatigue
heart failure
  • 88 views
  • 23 Nov, 2020
  • 1 location
Study of Efficacy of Oral Sacubitril/Valsartan in Adult Patients With Non-obstructive Hypertrophic Cardiomyopathy

The purpose of this study is to determine if LCZ696 is safe, tolerable and can improve exercise capacity (via improved peak VO2) in non-obstructive HCM patient population over the course of 50 weeks of treatment.

hypertrophic obstructive cardiomyopathy
hypertrophy
exercise test
cpet
nt-probnp
  • 2 views
  • 26 Nov, 2020
  • 14 locations
First-in-Human Study of NI006 in Patients With Amyloid Transthyretin Cardiomyopathy

extension phase in subjects with Amyloid Transthyretin Cardiomyopathy (ATTR-CM).

  • 0 views
  • 19 Oct, 2020
  • 7 locations
Is There a Genetic Predisposition for Acute Stress-induced (Takotsubo) Cardiomyopathy

Acute stress-induced (takotsubo) cardiomyopathy or broken heart syndrome presents like a heart attack, classically is triggered by intense emotional or physical stress and can have serious

  • 0 views
  • 20 Aug, 2020
  • 1 location
Exploratory Study of MYK-491 in Patients With Primary Dilated Cardiomyopathy (DCM) Due to Genetic Variants

The purpose of this Phase 2a study is to establish safety and tolerability of treatment with MYK-491 in patients with primary dilated cardiomyopathy (DCM) due to MYH7 or TTN variants .

  • 0 views
  • 30 Dec, 2020
  • 8 locations
CCM in Heart Failure With Preserved Ejection Fraction

This pilot study will evaluate the efficacy and safety of CCM therapy in heart failure patients with baseline EF50% (HFpEF) who have New York Heart Association (NYHA) Class II or III symptoms despite appropriate medication. The terminology of the HF classification HFpEF is based on the 2016 European Society of …

ejection fraction
nt-probnp
medical therapy
crescendo
heart failure with preserved ejection fraction
  • 52 views
  • 10 Sep, 2020
  • 40 locations
Non-invasive Mapping of Rhythm Disorders

This current care protocol follows the biomedical research protocol entitled "Non-invasive mapping of the heart ECG high amplification" that demonstrated the clinical value of noninvasive Cardioinsight mapping system. Guide the management of patients hospitalized for cardiac rhythm radiofrequency ablation of cardiac arrhythmias, implantation or programming of a pacemaker, or assess …

  • 0 views
  • 08 Nov, 2020
  • 1 location
Study of Verinurad in Heart Failure With Preserved Ejection Fraction

International, Multicenter, Double-Blind, 3-Arm, Placebo and Active Control Efficacy and Safety Study to Evaluate Verinurad combined with Allopurinol in Heart Failure with Preserved Ejection Fraction

  • 0 views
  • 10 Jan, 2021
  • 72 locations