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Found 146 clinical trials
Paclitaxel-coated Balloon for Treatment of De-novo Non-complex Coronary Artery Lesions

that at 12-month follow-up, DCB was non-inferior to DES (MACE [cardiac death, non-fatal myocardial infarction, and target-vessel revascularisation] rates: 8% vs. 9%). Although some small-scale

coronary angioplasty
infarct
revascularisation
clopidogrel
percutaneous coronary intervention
  • 0 views
  • 30 Jun, 2021
  • 1 location
Amiodarone Against ICD Therapy in Chagas Cardiomyopathy for Primary Prevention of Death

The primary objective is to compare the efficacy of the treatment using implantable cardioverter defibrillator (ICD) implantation to that of the treatment using amiodarone in the primary prevention of all-cause mortality in high-risk patients with Chagas cardiomyopathy and non-sustained ventricular tachycardia (NSVT).

ventricular tachycardia
amiodarone
  • 0 views
  • 08 Sep, 2021
  • 20 locations
Non-ischemic Preservation of the Donor Heart in Heart Transplantation

The study intends to compare standard ischemic cold static storage (ICSS) of retrieved hearts intended to be transplanted, to non-ischemic heart preservation (NIHP) in a randomized clinical multicentre trial. The primary hypothesis is that the non-ischemic hypothermic cardioplegic preservation (NIHP) is safe and superior to ischemic cold static storage (ICSS) …

heart transplant
lupus
heart transplantation
heart disease
organ transplantation
  • 0 views
  • 09 Mar, 2021
  • 9 locations
Atrial Sensing Capability for Better Detection of Atrial Fibrillation

This prospective multi-center randomized controlled study aims to compare atrial fibrillation detection and inappropriate therapy according to activation of atrial sensing capability in patients with implantable cardioverter defibrillator.

fibrillation
electrocardiogram
implantable cardioverter-defibrillators
  • 0 views
  • 10 Oct, 2021
  • 28 locations
Interventional Strategy for Non-culprit Lesions With Major Vulnerability Criteria at OCT in Patients With ACS

The INTERCLIMA (Interventional Strategy for Non-culprit Lesions With Major Vulnerability Criteria Identified by Optical Coherence Tomography in Patients With Acute Coronary Syndrome) is a multi-center, prospective, randomized trial of optical coherence tomography (OCT)-based versus physiology-based (i.e. fractional flow reserve[FFR]/instantaneous Wave-Free Ratio[iFR]/resting full-cycle ratio[RFR]) treatment of intermediate (40-70% diameter stenosis at …

acute coronary syndrome
stenosis
angiography
  • 0 views
  • 06 Sep, 2021
  • 1 location
Safety and Cost-efficiëncy of New Imaging Techniques in Patients Suspected of Coronary Artery Disease (iCORONARY)

Yearly, 180 000 patients in the Netherlands are referred to a cardiologist with symptoms suspected of coronary artery disease (CAD). To assess this, multiple diagnostic tests are available. Non-invasive imaging tests, such as coronary CT-scan, are safe, relatively cheap and can effectively rule-out CAD. However, when CAD is present, coronary …

coronary ct
stenosis
angina pectoris
angiography
  • 0 views
  • 05 Jun, 2022
  • 1 location
Direct Complete Versus Staged Complete Revascularization in Patients Presenting With Acute Coronary Syndromes and Multivessel Disease (BioVasc)

To test whether immediate complete revascularization is non-inferior to staged (but within six weeks after index procedure) complete revascularization in Patients presenting with ACS, including Non-ST-elevation ACS (NSTEACS) and ST-elevation myocardial infarction (STEMI), with multivessel disease accepted for PCI

ck-mb
unstable angina
infarct
troponin
creatine kinase mb
  • 0 views
  • 12 Feb, 2022
  • 1 location
Pragmatic Randomised Trial of the ESC 0/1 Versus 0/3 Hour Troponin Pathway (MACROS2)

The primary objective of this study is to assess the feasibility and impact of implementing the ESC 0-1 hour high sensitive troponin pathway in clinical practice and with specific reference to the 0-3 hour pathway currently in use. The principal outcome measure will be the safety of the 0-1 hour …

  • 0 views
  • 23 Apr, 2022
Treatment of Hypertension During Sleep (THADEUS)

On the basis of new evidence on the relationship between achieved office blood pressure (BP) measurements (OBPM) and the risk of cardiovascular disease (CVD) morbidity and mortality documented in the SPRINT trial, the recent 2017 guidelines of the American College of Cardiology (ACC) and the American Heart Association (AHA) have …

ambulatory blood pressure monitoring
diabetes
blood pressure diastolic
cardiovascular disease
nephropathy
  • 63 views
  • 27 Feb, 2022
  • 9 locations
Early Dronedarone Versus Usual Care to Improve Outcomes in Persons With Newly Diagnosed Atrial Fibrillation (CHANGE-AFIB)

While there are several completed clinical trials that address treatment strategy in patients with symptomatic and recurrent AF, there are no randomized clinical trials that address treatment for first-detected AF. In usual care, these patients are started on an atrioventricular nodal blocking agent (beta-blocker or non-dihydropyridine calcium channel blocker) along …

fibrillation
dronedarone
beta blockers
vascular disease
antiarrhythmic drug
  • 0 views
  • 01 Jul, 2022
  • 10 locations