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Found 40 clinical trials
Cardiovascular Protection Conservative Effects of Esketamine Versus µ-opioid Receptor Agonists in General Anesthesia

the perioperative incidence of adverse cardiovascular events and alteration of cardiac troponin I (cTnI) in the patients (one thousand patients, ASA Physical Status 1-II, older than 16 years

  • 0 views
  • 02 May, 2022
  • 1 location
Ischaemic PReconditioning In Non Cardiac surgEry

Several randomized trials suggested a cardioprotective beneficial effect (eg reduction in cardiac troponin release) of remote ischemic preconditioning in cardiac surgery. Remote ischemic

anesthesia
antiplatelet therapy
cardiovascular complications
heart surgery
propofol
  • 19 views
  • 29 Dec, 2021
  • 5 locations
Aiming Towards Evidence Based Interpretation of Cardiac Biomarkers in Patients Presenting With Chest Pain Using Point of Care Assays (WESTCOR-POC)

The aim of the current study is to perform a RCT comparing safety and efficiency of a standard care (in-line with current ESC recommendations) to an algorithm that utilize a POC troponin tests for bedside measurement, the instruments could be located in the ED and return results in few minutes.

  • 0 views
  • 11 May, 2022
  • 1 location
Hs-cTn - Optimizing the Diagnosis of Acute Myocardial Infarction/Injury in Women (CODE-MI)

The project is focussed on evaluating the impact of using a female-specific threshold in the diagnosis of myocardial infarction. This female threshold is lower than the overall hs-cTn threshold currently in use. The investigators hypothesize that this change in process, applied at the hospital level, will lead to better assessment, …

acute myocardial infarction
myocardial infarction
ischemia
infarct
chest pain
  • 1 views
  • 27 Feb, 2022
  • 1 location
A Phase 3 Study of Zalunfiban in Subjects With ST-elevation MI (CELEBRATE)

This is a Phase 3 prospective, blinded, randomized, placebo controlled, international multicenter study. Subjects with STEMI will be enrolled in the ambulance if they meet all eligibility criteria. These subjects will be evaluated by (para)medics who transport the subjects to the participating hospitals in Europe and North America. Hospitals and …

chest pain
stemi
angiography
  • 0 views
  • 23 May, 2022
  • 13 locations
A Study of Population and Sex-specific Troponin Cutoffs for Ruling Out Acute Myocardial Infarction (DANSPOT)

Acute myocardial infarction (MI) is defined as a rise and/or fall in cardiac troponins with at least one value above the 99th percentile upper reference limit (URL) in the context of symptoms or clinical evidence of myocardial ischemia. The URL is based on measurements in a healthy reference population. Currently, …

Accepts healthy volunteers
  • 0 views
  • 02 May, 2022
A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

This phase III trial compares standard chemotherapy to therapy with liposome-encapsulated daunorubicin-cytarabine (CPX-351) and/or gilteritinib for patients with newly diagnosed acute myeloid leukemia with or without FLT3 mutations. Drugs used in chemotherapy, such as daunorubicin, cytarabine, and gemtuzumab ozogamicin, work in different ways to stop the growth of cancer cells, …

gemtuzumab
cancer
mitoxantrone
daunorubicin
cytarabine/daunorubicin
  • 141 views
  • 10 May, 2022
  • 98 locations
Volatile Anesthetics in Cardiac Protection

Patients undergoing stenting procedures, or cardiac or non-cardiac surgery could develop myocardial damage as testified by cardiac troponin release. Sevoflurane (volatile anesthetic

intravenous anesthesia
cardiac operation
sevoflurane
  • 19 views
  • 04 Jul, 2022
Corticosteroids and Myocardial Injury in CAP (COLOSSEUM TRIAL)

Community-acquired pneumonia (CAP) is often complicated by elevation of cardiac troponin, a marker of myocardial injury, that can be isolated or associated to myocardial infarction (MI). A

  • 0 views
  • 06 Oct, 2021
  • 1 location
TrAstuzumab Cardiomyopathy Therapeutic Intervention With Carvedilol (TACTIC)

when significant heart function decline or subtle early signs of heart injury (either by elevation of a cardiac blood biomarker, i.e. cardiac troponin, or by an abnormal heart ultrasound marker, i.e

trastuzumab
erbb2
mammogram
her2/neu-positive breast cancer
lapatinib
  • 1 views
  • 21 Mar, 2022
  • 3 locations